Supergoop! Glowscreen for skin with dark spots

Questions and answers

What the research says

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Encapsulating avobenzone in low-porosity TiO2-embedded mesoporous silica (TiO2/SBA-S) reduced cutaneous avobenzone absorption from 0.76 to 0.50 nmol/mg while providing effective pollutant adsorbability, UVA protection, and a two- to three-fold reduction in photoaged skin cytokines/chemokines compared to the non-treatment control.

  European Journal of Pharmaceutical Sciences, 2023

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Encapsulation of ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles significantly reduced their in vivo human skin penetration compared to nonencapsulated filters.

  Skin Pharmacology and Physiology, 2011

• Microencapsulation of the BMDBM/HP-beta-CD complex in lipid microparticles significantly decreased the percutaneous penetration of the UV filter into the stratum corneum of human volunteers compared to the non-encapsulated sunscreen agent.

  Journal of Pharmaceutical and Biomedical Analysis, 2011

• Following human skin application of an O/W emulsion containing 2% BMDBM loaded in lipospheres, 15% of the sunscreen accumulated in the uppermost layers of the stratum corneum without remarkably modifying skin permeation compared to unencapsulated sunscreen.

  Skin Pharmacology and Physiology, 2008

• Simulated real-life dermal sunscreen exposure in twenty human volunteers leads to the systemic bioavailability and urinary excretion of the UV filter 2-ethylhexyl salicylate and its metabolite, reaching concentration peaks at 7 to 8 hours with 70-80% of overall excretion within 24 hours.

  Archives of Toxicology, 2019

• The application of a sunscreen formulation containing ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene does not significantly affect critical acne-related species such as Cutibacterium acnes and Staphylococcus epidermidis, refuting the induction of facial dysbiosis in men.

  Archives of Dermatological Research, 2024

• Controlled single dermal exposure to an EHS-containing sunscreen in three volunteers resulted in delayed systemic resorption with elimination half-lives between 6.6 and 9.7 hours, where the parent compound EHS occurred as the dominant urinary parameter.

  Archives of Toxicology, 2024

• Incorporating rosmarinic acid into sunscreens enhanced the in vivo SPF of octocrylene by over 157% and reduced lipid peroxidation in the human stratum corneum.

  Antioxidants, 2025

• Early application of sunscreen after ablative fractional skin resurfacing significantly increased the sensitization rate of the UV-filter, octocrylene, and the sunscreen compared to intact skin.

  The Journal of Dermatological Treatment, 2015

• Dermal sunscreen exposure in 20 healthy volunteers led to plasma concentrations of avobenzone, octocrylene, and its metabolite CDAA reaching up to 11 μg/L, 25 μg/L, and 1352 μg/L, respectively.

  Environment International, 2019

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

Why other products fit skin with dark spots better

• Daily application of a cream containing niosomes loaded with purple glutinous rice extract in 20 human volunteers for 28 days resulted in a significant decrease in melanin index and skin roughness by -14.05% and -9.95%, and increases in skin hydration and elastic recovery by +48.73% and +35.98% compared to initial values.

  International Journal of Cosmetic Science, 2020

Ingredients

Avobenzone, Octisalate, Octocrylene, Water, Propanediol, Butyloctyl Salicylate, Glycerin, C12-15 Alkyl Benzoate, Polymethylsilsesquioxane, Niacinamide, Glyceryl Stearate Citrate, Bismuth Oxychloride, Mica, Titanium Dioxide, Lauryl Lactate, Isododecane, Isodecyl Neopentanoate, Glyceryl Stearate, Diisopropyl Sebacate, Cetyl Phosphate, Caprylic Capric Triglyceride, Coco-Caprylate, Ethylhexyl Hydroxystearate, Butylene Glycol, Arginine, Hydroxyacetophenone, Caprylyl Glycol, 1,2-Hexanediol, Iron Oxides, Sodium Hyaluronate, Chlorphenesin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Trisodium Ethylenediamine Disuccinate, Limonium Gerberi Extract, Leuconostoc Radish Root Ferment Filtrate, Theobroma Cacao Seed Extract, Pantothenic Acid, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Ferulic Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.