# SkinMedica TNS Advanced+ Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [SkinMedica](https://lovi.care/skincare/ca/brands/skinmedica)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- This serum offers moderate benefits for your oily skin, with Human Fibroblast Conditioned Media and Trifluoroacetyl Tripeptide-2 providing skin rejuvenation to minimize fine lines and texture.
- Glycerin and Shea Ethyl Esters Butter offer supportive hydration for your acne and oiliness, while Lactococcus Lysate Ferment and Whey Protein aid in barrier repair.
- The product is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Human Fibroblast Conditioned Media, Collagen Peptides, Trifluoroacetyl Tripeptide-2, Glycerin, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract

## What the research says

- Topical application of human fibroblast conditioned media and its derived growth factors and exosomes significantly reduces signs of skin aging and stimulates skin recovery and quality after in-office cosmetic procedures. ([Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls. ([Frontiers in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38751975/))
- Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls. ([Journal of Agricultural and Food Chemistry, 2020](https://pubmed.ncbi.nlm.nih.gov/31967468/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.

- Liked: Improves fine lines (mostly mentioned)
- Disliked: Very expensive price (mostly mentioned)
- Liked: Firms sagging skin (often mentioned)
- Liked: Smoothes skin texture (often mentioned)
- Disliked: Faulty pump dispenser (often mentioned)
- Liked: Safe for sensitive skin (sometimes noted)
- Disliked: Uneven product dispensing (sometimes noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does SkinMedica TNS Advanced+ work for oily acne-prone skin?

SkinMedica TNS Advanced+ works moderately well for oily acne-prone skin, offering rejuvenation to smooth fine lines along with supportive hydration and barrier repair. It is safe and unlikely to cause irritation, though treatments for this skin type typically need ingredients like niacinamide, propolis, or Vitamin C for effective oil control and blemish management.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Glycerin helps provide supportive hydration for your oily skin, while Human Fibroblast Conditioned Media helps minimize fine lines and texture. To work best for oily acne-prone skin, a treatment of this type needs ingredients like niacinamide, propolis, or Vitamin C to control excess oil and address blemishes without heavy or pore-clogging components.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Human Fibroblast Conditioned Media do for oily acne-prone skin?

Human Fibroblast Conditioned Media helps calm oily, acne-prone skin and supports faster skin recovery after breakouts. It works by using growth factors that encourage healing and improve overall skin quality, though individual results may vary.
Sources: [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/)

### What do Collagen Peptides do for oily acne-prone skin?

Collagen peptides help support skin moisture and elasticity for oily, acne-prone skin, while also helping to balance sebum production. Regular oral intake may improve overall skin texture and help maintain a healthy look without adding heavy oils.
Sources: [Oxidative Medicine and Cellular Longevity, 2016](https://pubmed.ncbi.nlm.nih.gov/26904164/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26362110/)

### Where does it go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying it after your cleanser and toner, followed by your moisturizer. When using both, the routine is safe for oily skin and helps keep your skin comfortable.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use it?

This serum works in your evening routine as a treatment step, and while it is safe for your oily skin, other products of this type fit this skin better by focusing on oil control and lightweight hydration.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on oily acne-prone skin because it lacks harsh or irritating ingredients. It provides moderate benefits with ingredients like glycerin for supportive hydration and human fibroblast conditioned media for skin rejuvenation, though an oily acne-prone skin type needs oil-free hydrators and pore-clearing ingredients like salicylic acid for a better fit.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$412.66 (https://www.amazon.ca/dp/B0H1VPF7Z8?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin