# SkinCeuticals Phloretin CF for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [SkinCeuticals](https://lovi.care/skincare/ca/brands/skinceuticals)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, as ascorbic acid and ferulic acid provide antioxidant protection and help with fine lines and wrinkles. These ingredients are well-suited for normal skin, offering good antioxidant activity.
- The formula is generally safe for your normal skin, with no harsh ingredients that would cause irritation.
- While it offers good antioxidant protection and brightening, it does not provide the most potent treatment for wrinkles and fine lines.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/oily-acne-prone-skin): High

## Key ingredients

Phloretin, Ascorbic Acid, Ferulic Acid

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Phloretin inhibits the growth of acne-related bacteria, attenuates P. acnes-induced inflammatory mediators in vitro, and significantly reduces comedo counts, sebum output, and porphyrin levels in subjects with whiteheads compared to before treatment. ([International Journal of Cosmetic Science, 2016](https://pubmed.ncbi.nlm.nih.gov/26212527/))
- Phloretin 3',3-disulfonate attenuated UVB-induced cyclobutane pyrimidine dimer formation, glutathione depletion, apoptosis, and inflammatory mediator release in skin cells by enhancing nucleotide excision repair gene expression. ([International Journal of Molecular Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25334063/))
- Compound 11c showed potent inhibitory activity against tyrosinase at nanomolar concentrations and reduced melanin content in a UV-induced skin pigmentation guinea pig model. ([Journal of Medicinal Chemistry, 2023](https://pubmed.ncbi.nlm.nih.gov/36940414/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Topical ferulic acid-containing formulations effectively reduce skin erythema, hyperpigmentation, and signs of aging in adults compared to baseline or alternative conditions. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40538529/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Based on a very large amount of data, this product is highly regarded for brightening the complexion, evening skin tone, and reducing discoloration such as dark spots and melasma, particularly benefiting those with normal, oily, combination, or acne-prone skin. Many users report achieving smoother, more radiant skin and a decrease in fine lines. However, a significant number of reviews mention the high cost, a strong scent, and occasional issues with stickiness or packaging.

- Liked: Brightens skin (mostly mentioned)
- Liked: Fades discoloration (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Good for oily skin (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does SkinCeuticals Phloretin CF work for mature skin?

SkinCeuticals Phloretin CF works moderately well for mature skin, as its ingredients provide good antioxidant protection and help with fine lines and wrinkles. While it is generally safe and helps brighten the skin, it does not provide the most potent anti-aging treatment. Products that fit mature skin better need high-quality anti-aging ingredients, potent antioxidants, hydrating components, and skin-repairing elements that improve skin elasticity and moisture retention.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/)

### Which ingredients make this serum a good fit for mature skin?

Phloretin, ascorbic acid, and ferulic acid make this serum a good fit for mature skin by providing antioxidant protection and helping with fine lines and wrinkles. To give this skin a better fit, a product needs high-quality anti-aging ingredients, potent antioxidants, hydrating components, skin-repairing ingredients, peptides, and moisture-retaining agents.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/), [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/)

### What does Phloretin do for mature skin?

Phloretin helps protect your skin from sun damage that leads to early aging. It may also calm irritation and keep your skin cells healthy under UV exposure.
Sources: [International Journal of Molecular Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25334063/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in your evening routine, applied after cleansing and toning and before your moisturizer. While it offers moderate antioxidant protection and brightening for mature skin, this skin type ultimately needs more potent ingredients and treatments for wrinkles and fine lines.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum in your morning routine and retinol at night, keeping them separate to avoid irritation. This product needs powerful collagen-boosting ingredients and deeper firming treatments to properly care for mature skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/)

### How often should I use it?

Apply this treatment in the evening, starting once a week and carefully using it more often if your skin tolerates it well and shows good results.

### Can it clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a generally safe formula without harsh ingredients that cause irritation.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for mature skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/mature-skin) — High fit — CA$27.99 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/mature-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Dipropylene Glycol, Alcohol Denat, Ascorbic Acid, Butylene Glycol, Triethyl Citrate, Phloretin, Ferulic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinceuticals/phloretin-cf/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/skinceuticals/phloretin-cf/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/skinceuticals/phloretin-cf/for/mature-skin
- France: https://lovi.care/skincare/fr/p/skinceuticals/phloretin-cf/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/skinceuticals/phloretin-cf/for/mature-skin
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- Spain: https://lovi.care/skincare/es/p/skinceuticals/phloretin-cf/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/skinceuticals/phloretin-cf/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/skinceuticals/phloretin-cf/for/mature-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/skinceuticals/phloretin-cf/for/mature-skin