# Skinbetter Science AlphaRet Overnight Cream for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Skinbetter Science](https://lovi.care/skincare/ca/brands/skinbetter-science)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as glycolic acid and ethyl lactyl retinoate provide exfoliation and renewal, but it lacks sufficient ingredients for optimal oil control on your oily areas.
- The formula provides excellent moisturizing and texture smoothing due to ethyl lactyl retinoate and sodium hyaluronate, and glycerin and niacinamide offer general hydration and soothing benefits supportive for combination skin.
- The product is generally safe for your combination skin, though there is some risk of irritation from glycolic acid and ethyl lactyl retinoate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Glycolic Acid, Niacinamide, Ethyl Lactyl Retinoate, Sodium Hyaluronate, Squalane

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users consistently praise this cream as a "game-changer" for sensitive and aging skin, noting visible improvements in texture, tone, and fine lines without the harsh side effects typical of retinoids. While highly effective for smoothing rough skin and clearing pigmentation, a small minority of users experienced initial purging or found the hydration insufficient for very dry skin types.

- Liked: Gentle & non-irritating (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Effective anti-aging (often mentioned)
- Liked: Improves texture & tone (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Liked: Packaging design (sometimes noted)
- Disliked: Initial purging (rarely noted)
- Disliked: Not moisturizing enough (rarely noted)
- Disliked: Packaging malfunctions (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does AlphaRet Overnight Cream work for combination skin?

This cream works moderately well for combination skin because glycolic acid and ethyl lactyl retinoate exfoliate and renew the skin, but it lacks sufficient ingredients for optimal oil control on oily areas. An ideal product of this type needs effective brightening and moisturizing ingredients that reduce oily shine without irritation, while featuring soothing agents and antioxidants for balanced skin health.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this cream a good fit for combination skin?

Glycolic acid and ethyl lactyl retinoate help renew your skin, while sodium hyaluronate, glycerin, and niacinamide provide essential moisture and calming benefits. However, a product for this skin also needs ingredients that offer optimal oil control on oily areas to reduce shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Glycolic Acid do for combination skin?

Glycolic acid helps smooth and brighten combination skin by gently loosening dead surface cells to speed up skin renewal. This ingredient is unlikely to cause irritation when used properly, but it needs a reliable sunscreen during the day since it makes skin more sensitive to the sun.
Sources: [Acta Dermato-venereologica, 1995](https://pubmed.ncbi.nlm.nih.gov/8651024/), [Archives of Dermatological Research, 1997](https://pubmed.ncbi.nlm.nih.gov/9248619/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this cream go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Combination skin needs a product that provides exfoliation and renewal while also including sufficient oil control ingredients for oily areas.

### Can I use this cream with retinol, and in what order?

Skinbetter Science AlphaRet Overnight Cream already contains a retinoid and glycolic acid, so layering it with another separate retinol product is generally unnecessary and may increase the risk of skin irritation. To use this treatment, apply it in the evening after cleansing and toning, and follow with a simple moisturizer if your skin feels dry. This type of skin needs ingredients that help balance oil on oily zones while smoothing texture.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this treatment cream in the evening, starting once a week and gradually increasing frequency if your skin tolerates it well. Combination skin needs a product of this type that also balances oil in shiny areas while smoothing and hydrating.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores, but there is a low risk of initial purging on combination skin due to the exfoliating ingredients. A product for this skin needs stronger oil control ingredients to better manage oily areas.

### Can I use this cream around the eyes or on my body?

This cream works safely on the body, but the skin around your eyes is much thinner and may be more easily irritated by the exfoliating ingredients like glycolic acid. To care for combination skin effectively, this type of product needs extra ingredients that help balance oil in your oily areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin) — Superior fit — CA$95.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/ca/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — CA$16.20 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/ca/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/combination-skin) — High fit — CA$98.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Glycolate, Glycolic Acid, Cetearyl Olivate, Pentylene Glycol, Cyclopentasiloxane, Isohexadecane, Sorbitan Olivate, Tetrahexyldecyl Ascorbate, Glycerin, Ceresin, Glycol Palmitate, Butylene Glycol, Niacinamide, Squalane, Methyl Gluceth-20, Ethyl Lactyl Retinoate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide Np, Sodium Hyaluronate, Ubiquinone, Tocopherol, Bisabolol, Tocopheryl Acetate, Superoxide Dismutase, Butyrospermum Parkii Butter Shea Butter, Allantoin Glycyrrhetinic Acid, Sodium Pca, Panthenol, Camellia Sinensis Leaf Extract, Portulaca Oleracea Extract, Linoleic Acid, Cholesterol, Linolenic Acid, Magnesium Aluminum Silicate, Dimethyl Isosorbide, Dimethicone, Glyceryl Stearate, Peg-100 Stearate, Steareth-2, Hydroxyethylcellulose, Acacia Senegal Gum, Xanthan Gum, Hydrated Silica, Carbomer, Polysorbate 20, Tromethamine, Disodium Edta, Ethylhexylglycerin, Phenoxyethanol, Titanium Dioxide Ci 77891
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinbetter-science/alpharet-overnight-cream/for/combination-skin