# SKIN1004 Probio-Cica Intensive Ampoule for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [SKIN1004](https://lovi.care/skincare/ca/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin due to the presence of Centella Asiatica Extract and Niacinamide, which offer anti-inflammatory action and barrier repair.
- Offers moderate benefits for pigmentation due to the presence of Niacinamide in concentrations that support brightening.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Niacinamide, Glycerin, Butylene Glycol, Propanediol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))

## What reviewers say

This ampoule is widely celebrated as a holy grail for repairing damaged skin barriers and soothing irritation, particularly for those with dry, sensitive, or acne-prone skin. Users consistently report a glass skin effect, noting that the milky, viscous texture provides deep hydration and calms redness without leaving a heavy residue. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Barrier repair (often mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Gentle/non-irritating (often mentioned)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Texture heaviness (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Skin1004 Probio-Cica Intensive Ampoule a great fit for skin with dark spots?

Skin1004 Probio-Cica Intensive Ampoule is a great fit for skin with dark spots because it contains Niacinamide, which helps brighten skin and reduce dark spots. It also features Centella Asiatica Extract to calm skin and repair your skin barrier safely without irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this ampoule a good fit for skin with dark spots?

Niacinamide and Centella Asiatica Extract make this ampoule a great fit by helping to brighten dark spots and calm the skin. Niacinamide supports brightening by reducing dark spots, while Centella Asiatica Extract helps keep the skin calm and comfortable.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Centella Asiatica Extract do for skin with dark spots?

Centella Asiatica Extract helps fade dark spots by slowing down the process that creates excess pigment in the skin. It also provides strong antioxidant and calming benefits that support a smooth, even tone.
Sources: [Molecular Medicine Reports, 2014](https://pubmed.ncbi.nlm.nih.gov/24756377/), [International Journal of Molecular Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39513603/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this ampoule go in a skincare routine for skin with dark spots?

This ampoule goes in your evening routine as a treatment step after cleansing and toning, followed by your moisturizer. Using it at night provides extra safety around sun exposure, while its niacinamide helps brighten dark spots.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this ampoule with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the treatment first and then following with your retinol. Because this product has a gentle formula that calms the skin, it helps keep your skin comfortable while you use retinol.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this ampoule?

This treatment is a great fit for your skin with dark spots because it includes Niacinamide, which helps brighten uneven tone, alongside Centella Asiatica Extract to calm and soothe. You can use it in your evening routine, as treatments with active ingredients are placed at night for simplicity and safety around sun exposure.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can this ampoule clog pores, cause breakouts or purging for skin with dark spots?

This ampoule is unlikely to cause breakouts or clog pores on skin with dark spots because it has an excellent safety profile without harsh ingredients. Reviewers only rarely complain about potential breakouts.

### Is this ampoule fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/ca/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — CA$250.04 at Amazon
- [Neutrogena Rapid Tone Repair Vitamin C Serum](https://lovi.care/skincare/ca/p/neutrogena/rapid-tone-repair-20-vitamin-c-face-serum-capsules/for/dark-spots) — High fit — CA$63.07 at Amazon
- [The Ordinary Buffet + Copper Peptides 1%](https://lovi.care/skincare/ca/p/the-ordinary/buffet-copper-peptides-1/for/dark-spots) — High fit — CA$39.50 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/ca/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — CA$23.99 at Amazon
- Moisturizer: [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/ca/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/dark-spots) — High fit — CA$98.99 at Amazon

## Where to buy

- Amazon.ca: CA$24.44 (https://www.amazon.ca/dp/B0BTRWGQNV?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Centella Asiatica Extract, Butylene Glycol, Glycerin, Water, Propanediol, Caprylic Capric Triglyceride, Niacinamide, 1,2-Hexanediol, Dipropylene Glycol, Polyglyceryl-4 Isostearate, Kidney Vetch
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- France: https://lovi.care/skincare/fr/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots (this page)
- Australia: https://lovi.care/skincare/au/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots