# Skin Better Science Alto Advanced Defense and Repair Serum for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Skin Better Science](https://lovi.care/skincare/ca/brands/skin-better-science)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your dry skin is provided by ingredients like Glycerin and Sodium PCA, which offer significant hydration, and Linoleic Acid and Linolenic Acid that help repair your skin barrier.
- The serum also offers robust protection against environmental stressors due to antioxidants such as Ergothioneine and Ubiquinone.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the inclusion of soothing agents like Bisabolol and Glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Superoxide Dismutase, Tetrahexyldecyl Ascorbate, Carnosine, Ceramide Ap

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical treatment with coenzyme Q10 formulas replenishes Q10 levels in the skin surface and deeper epidermis, augments cellular energy metabolism, and reduces free radicals while increasing antioxidant capacity in stressed skin. ([BioFactors, 2015](https://pubmed.ncbi.nlm.nih.gov/26648450/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use. ([Dermatology and Therapy, 2020](https://pubmed.ncbi.nlm.nih.gov/32915393/))
- Supramolecular carnosine improves skin reactivity, upregulates Nrf2 expression, activates antioxidant defenses, and reduces AGE levels while demonstrating whitening efficacy in cells and clinical tests compared to conventional carnosine. ([Advanced Healthcare Materials, 2024](https://pubmed.ncbi.nlm.nih.gov/39279568/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Alto Advanced Defense and Repair Serum a great fit for dry skin?

This serum is a great fit for your dry skin because it provides significant hydration and helps repair your skin barrier using ingredients like glycerin, sodium PCA, linoleic acid, and linolenic acid. It also protects against environmental stressors with antioxidants while keeping your skin calm and safe from irritation.

### Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for dry skin thanks to ingredients like glycerin and sodium PCA, which provide deep hydration, and linoleic and linolenic acids that help repair the skin barrier. It is also very safe and soothing for dry skin due to the lack of harsh ingredients and the inclusion of bisabolol and glycerin.

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### What does Superoxide Dismutase do for dry skin?

Superoxide Dismutase helps calm dry skin by acting as an antioxidant that reduces oxidative stress. A product of this type needs soothing ingredients and moisture-locking agents to restore comfort and support a healthy skin barrier.
Sources: [Skin Pharmacology, 1997](https://pubmed.ncbi.nlm.nih.gov/9449171/), [Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/39204346/)

### Where does this serum go in a skincare routine for dry skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, though some can also be used in the morning or twice a day. Applying it at night provides extra safety around sun exposure and keeps your routine simple.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment in your evening routine after cleansing and before your moisturizer. It is unlikely to cause irritation on dry skin because it contains soothing ingredients like glycerin and bisabolol.

### How often should I use this serum?

This treatment serum is used in your evening routine, applied after cleansing and before moisturizing. You can start by using it a few evenings a week and gradually increase to daily use as your dry skin adjusts.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on dry skin. It has an excellent safety profile with no harsh ingredients that typically cause irritation or breakouts.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ca/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — CA$40.00 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — CA$22.49 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — CA$20.19 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/ca/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — CA$27.99 at Amazon
- Moisturizer: [Tata Harper Repairative Moisturizer](https://lovi.care/skincare/ca/p/tata-harper/repairative-moisturizer/for/dry-skin) — Superior fit — CA$162.00 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Acacia Decurrens Wax Flower, Acacia Senegal Gum, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Water, Arabidopsis Thaliana Extract, Arginine, Benzylidene Dimethoxydimethylindanone, Bisabolol, Buddleja Officinalis Flower Extract, Butylene Glycol, Camellia Sinensis Leaf Extract, Carbomer, Carnosine, Ceramide Ap, Ceramide Eop, Ceramide Np, Cetearyl Alcohol, Ceteth-20 Phosphate, Chlorogenic Acids, Cholesterol, Citric Acid, Coffea Arabica Extract Cell Leaf Coffee Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Curcuma Longa Root Extract, Dextran, Dicetyl Phosphate, Diisostearyl Malate, Dimethyl Isosorbide, Ergothioneine, Ethylhexyl Olivate, Ethylhexylglycerin, Euterpe Oleracea Fruit Extract, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Helianthus Annuus Wax Seed Sunflower Wax Seed, Hydrolyzed Sodium Hyaluronate, Jojoba Esters, Lauryl Lactate, Lecithin, Linoleic Acid, Linolenic Acid, Methyl Gluceth-20, Micrococcus Lysate, Niacinamide, Olea Europaea Fruit Extract Olive Fruit Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Pentylene Glycol, Phenoxyethanol, Phytosphingosine, Plankton Extract, Polyglycerin-3, Propanediol, Propanediol Dicaprylate Caprate, Pyrroloquinoline Quinone Allyl Ester, Ricinoleth-40, Sea Whip Extract, Sodium Hydroxide, Sodium Lauroyl Lactylate, Sodium Pca, Sodium Phytate, Steareth-2, Superoxide Dismutase, Tetrahexyldecyl Ascorbate, Theobroma Cacao Seed Extract, Tocopherol, Tocopheryl Acetate, Trifluoroacetyl Tripeptide-2, Ubiquinone, Vitis Vinifera Seed Extract Grape Seed Extract, Xanthan Gum, Zingiber Officinale Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin (this page)
- Australia: https://lovi.care/skincare/au/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin