# Shiseido Vital Perfection Intensive WrinkleSpot Treatment for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Shiseido](https://lovi.care/skincare/ca/brands/shiseido)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- This treatment offers excellent wrinkle reduction for your combination skin due to retinol and retinyl acetate, which work to minimize fine lines and wrinkles. Glycerin and betaine provide supportive hydration beneficial for oily shine, though the formula may not offer sufficient oil control for your oilier areas.
- The inclusion of Rosa Damascena Flower Water and Glycyrrhiza Glabra Root Extract contributes to soothing effects, making it generally well-tolerated.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, 4msk, Kurenai-Trulift Complex, Reneura Technology, Glycyrrhiza Glabra Root Extract Licorice Root Extract

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Potassium 4-methoxysalicylate (4MSK) suppresses melanin content, promotes keratinocyte differentiation, increases skin lightness in pigmented and non-pigmented cheek areas, and reduces the desquamation area ratio. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40071590/))
- An in situ hydrated ionic liquid-like state strategy using potassium 4-methoxysalicylate and arginine hydrochloride increased human skin permeation to 237% of control and reduced melanin content by 33% in a reconstructed human epidermis model. ([International Journal of Pharmaceutics, 2026](https://pubmed.ncbi.nlm.nih.gov/42822711/))
- Plant extracts from Gomphrena globasa L., Clitoria ternatea L., Carthamus tinctorius L., Punica granatum L., and Papaver rhoeas L. demonstrated no cytotoxicity, high antioxidant potential, strong collagenase inhibition, moderate elastase inhibition, effective skin hydration, and varying suitability as stable cosmetic dyes when tested on keratinocyte and fibroblast cell lines and incorporated into face cream formulations. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34068613/))
- Water extracts of Papaver rhoeas L., Punica granatum L., Clitoria ternatea L., Carthamus tinctorius L., and Gomphrena globosa L. showed no cytotoxicity on skin cells while exhibiting antioxidant, anti-inflammatory, and enzyme-inhibiting properties, with P. rhoeas, C. ternatea, and C. tinctorius demonstrating strong permanent coloring ability in cosmetic products. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35164187/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, users with mature or aging skin frequently report that this treatment visibly softens deep wrinkles and fades dark spots. Many users also note improvements in skin firmness and appreciate the effective targeted application. Some users with sensitive skin experience dryness or irritation, and a low number find the texture heavy or the product ineffective for their needs.

- Liked: Reduces wrinkles (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Liked: Targeted application (sometimes noted)
- Disliked: Causes dryness (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Irritates skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Shiseido Intensive WrinkleSpot Treatment work for combination skin?

This treatment works reasonably well for your combination skin by smoothing fine lines with retinol and retinyl acetate, though it may not control oil in your shine-prone areas quite as well as other options. To fit combination skin best, a product of this type needs ingredients like niacinamide, zinc PCA, or propolis to regulate oiliness and enhance radiance without causing excess shine or dryness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this treatment a good fit for combination skin?

This treatment works for your combination skin because retinol and retinyl acetate help minimize fine lines and wrinkles, while glycerin and betaine provide supportive hydration. To fit this skin type even better, a product needs effective ingredients like niacinamide, propolis, and zinc PCA to regulate oiliness and balance hydration without making oilier areas feel overwhelmed.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Retinol do for combination skin?

Retinol helps smooth fine lines, even out skin tone, and improve firmness in combination skin. It works by encouraging faster skin renewal and boosting collagen, though it may occasionally cause mild dryness or scaling while your skin adjusts.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does 4-Methoxy potassium salicylate do for combination skin?

Potassium 4-methoxysalicylate helps brighten dark spots and even out skin tone by slowing down excess pigment production while supporting healthy skin renewal. For combination skin, this ingredient works well to manage uneven areas without causing heavy buildup. A product for this skin type also needs balancing ingredients that hydrate dry areas while keeping oily zones feeling fresh and smooth.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40071590/), [International Journal of Pharmaceutics, 2026](https://pubmed.ncbi.nlm.nih.gov/42822711/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening provides simplicity and extra safety around sun exposure, though some can also be used in the morning or twice a day.

### Can I use this treatment with vitamin C, and in what order?

You can use this treatment with vitamin C by applying your vitamin C serum in the morning and saving this retinol treatment for your evening routine. Using them at different times of the day helps prevent potential skin irritation and keeps both ingredients working effectively.

### How often should I use this treatment?

Apply this treatment in your evening routine. Combination skin needs a product of this type that also balances oil and shine in the oilier zones while smoothing fine lines.

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is generally well-tolerated and is unlikely to cause major irritation on combination skin, though reviewers moderately report dryness. For combination skin, a product of this type needs balancing ingredients that provide lightweight hydration and oil control.

### Is this treatment fragrance-free and alcohol-free?

It contains fragrance (parfum, limonene, hexyl cinnamal, linalool, and citronellol) and drying alcohol (alcohol).

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dipropylene Glycol, Hydrogenated Polydecene, Glycerin, Betaine, Behenyl Alcohol, Dimethicone, Potassium Methoxysalicylate, Petrolatum, Hydrogenated Palm Oil, Stearyl Alcohol, Maltitol, Beheneth-20, Palm Kernel Oil, Phenoxyethanol, Butylene Glycol, Palm Oil, Carnauba Wax Cera Copernicia Cerifera Cire De Carnauba Wax Cera, Hydrogenated Polyisobutene, Polyvinyl Alcohol, Microcrystalline Wax Cera Microcristallina Cire Microcristalline Wax Cera, Parfum, Carbomer, Tocopheryl Acetate, Rosa Damascena Flower Water, Xanthan Gum, Bht, Retinol, Polysorbate 20, Alcohol, Caffeine, Potassium Hydroxide, Lavandula Angustifolia Oil Lavender Oil, Trisodium Edta, Ppg-3 Dipivalate, Limonene, Tocopherol, Hexyl Cinnamal, Linalool, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Citronellol, Angelica Acutiloba Root Extract, Angelica Keiskei Stem Extract Leaf, Olea Europaea Leaf Extract Olive Leaf Extract, Sanguisorba Officinalis Root Extract, Lamium Album Stem Extract Flower Leaf, Camellia Sinensis Leaf Extract, Inositol, Carthamus Tinctorius Flower Extract, Pinus Sylvestris Cone Extract, Ziziphus Jujuba Fruit Extract, Retinyl Acetate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Cellulose, Beta-Carotene, Cinnamomum Cassia Bark Extract, Citric Acid, Bupleurum Falcatum Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- France: https://lovi.care/skincare/fr/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin