# ROUND LAB Pine Calming Cica Ampoule for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [ROUND LAB](https://lovi.care/skincare/ca/brands/round-lab)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin calming and barrier support for your oily skin due to the presence of asiaticoside, madecassoside, and madecasic acid, which soothe irritation and enhance barrier resilience.
- The inclusion of capryloyl salicylic acid provides mild exfoliation and pore-refining effects, addressing your acne, blemishes, and breakouts while glycerin and sodium hyaluronate hydrate without exacerbating oiliness.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing compounds.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Pine Extract, Centella Asiatica Extract, Sodium Hyaluronate, Glycerin, Madecassoside

## What the research says

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- The novel high-payload nanosuspension system of Centella asiatica extract increased skin accumulation of asiatic acid, madecassic acid, and asiaticoside by 5-, 4-, and 4.5-fold respectively compared to a marketed cream in porcine skin, with no local skin irritation in normal rats. ([International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34764648/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- A xanthan gum and alginate-based bioadhesive film loaded with pycnogenol provides sustained drug release within 24 hours, achieves a safe maximum concentration of ~ 0.2 mg/mL for keratinocytes, and absorbs simulated wound fluid, demonstrating suitability for topical wound treatment. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33802607/))
- Topical treatment with Pinus brutia bark extract cream significantly accelerated incision wound healing in albino rats, demonstrating a 35% decrease in MDA and a 46.8% increase in SOD activity compared to the control group. ([Die Pharmazie, 2013](https://pubmed.ncbi.nlm.nih.gov/23444785/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this ampoule is highly recommended for those with sensitive, oily, and acne-prone skin due to its fast-absorbing, watery texture that effectively calms redness and inflammation without causing breakouts. Users appreciate its gentle formulation and ability to refine skin texture. However, individuals with dry skin may find it insufficient on its own and need to layer with a richer moisturizer.

- Liked: Soothing and calming (mostly mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Non-irritating formula (often mentioned)
- Liked: Gentle texture improvement (sometimes noted)
- Disliked: Insufficient for dry skin (sometimes noted)
- Disliked: Small volume/price (sometimes noted)
- Disliked: Breakouts/reactions (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ROUND LAB Pine Calming Cica Ampoule a great fit for oily acne-prone skin?

This ampoule is a great fit because it helps soothe irritation and calm breakouts on oily skin using madecassoside and capryloyl salicylic acid, while glycerin and sodium hyaluronate add light moisture without making you greasy. It has an excellent safety profile with no harsh ingredients, meaning it is unlikely to irritate your skin.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Pine Extract, Centella Asiatica derivatives like madecassoside, and capryloyl salicylic acid make this serum a great fit by soothing irritation, gently clearing pores, and keeping oily skin calm and clear. Glycerin and sodium hyaluronate add lightweight hydration without feeling heavy or greasy.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Pine Extract do for oily acne-prone skin?

Pine Extract helps oily, acne-prone skin by calming redness and keeping pores clear so you break out less. It is lightweight, so it leaves your face feeling fresh without feeling heavy or greasy.

### What does Centella Asiatica Extract do for oily acne-prone skin?

Centella Asiatica Extract helps calm red spots and supports skin healing in oily, acne-prone skin. It may also help balance moisture and reduce breakouts by soothing irritated areas.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. Using it at night helps keep your routine simple and avoids extra safety concerns around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying this serum first to calm your skin and hydrate it without adding oil, and then following with your retinol. Using soothing ingredients like madecassoside and Centella Asiatica helps keep your oily skin comfortable and lowers the likelihood of irritation from the retinol.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this serum?

This treatment is used in your evening routine, starting at once a week and gradually increasing as your skin adjusts well. Its soothing and hydrating ingredients help calm irritation and refine pores safely without making your oily skin feel greasy.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This ampoule is a great fit for oily acne-prone skin because it soothes irritation and refines pores without clogging them. It contains ingredients like capryloyl salicylic acid and Centella Asiatica extract that help clear breakouts and calm the skin with a very low risk of irritation.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$22.73 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Butylene Glycol, Dipropylene Glycol, Glycereth-26, Glycerin, 2-Hexanediol, Propanediol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Ethylhexyl Glycerin, Water, Glycoprotein, Indo Mulberry Leaf Extract, Yellow Lotus Root Extract, Indo Mulberry Flower Extract, Hydroxyacetophenone, Asiaticoside, Asiatic Acid, Madecassoside, Madecasic Acid, Sodium Citrate, Capryloyl Salicylic Acid, Disodium Edta, Xanthan Gum, Carbomer, Tromethamine, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
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- Spain: https://lovi.care/skincare/es/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/round-lab/pine-calming-cica-ampoule/for/oily-acne-prone-skin