# REJURAN Turnover Ampoule Dual Effect for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [REJURAN](https://lovi.care/skincare/ca/brands/rejuran)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration and soothing benefits for your normal skin, with hyaluronic acid and glycerin providing humectant action while squalane and ceramide NP support barrier repair.
- While beneficial for general skin health, the formula lacks targeted ingredients to address your primary concern of pigmentation.
- The product is safe for your normal skin, as it contains soothing agents like Bisabolol and Calendula Officinalis Flower Extract and avoids harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/oily-acne-prone-skin): Average

## Key ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract

## What the research says

- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A blackberry and dill extract combination synergistically increased skin elasticity and induced elastogenesis compared to each ingredient alone and placebo. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32583541/))
- Tropical highland blackberry juice reduced UVB-mediated DNA damage and increased apoptosis in human epidermal keratinocytes and a reconstituted skin equivalent model. ([Photochemistry and Photobiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23711186/))
- Strawberry and blackberry crude extracts, anthocyanin-enriched fractions, and proanthocyanidin-enriched fractions demonstrated anti-inflammatory effects through ROS reduction, gene expression inhibition, and NO suppression, while anthocyanin fractions promoted fibroblast migration in vitro. ([Food Research International, 2019](https://pubmed.ncbi.nlm.nih.gov/31108769/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Calendula officinalis extract cream significantly improved skin hydration and firmness (reflected in significant changes in R0 and R6 parameters) in 21 healthy human volunteers compared to a base cream. ([Acta Poloniae Pharmaceutica, 2011](https://pubmed.ncbi.nlm.nih.gov/21928714/))
- Treatment with standardized extract of Calendula officinalis L. led to a shorter epithelization time and faster healing speed compared to mineral oil in patients with acute skin loss wounds of the hand and fingers healing by secondary intention. ([Tissue Barriers, 2022](https://pubmed.ncbi.nlm.nih.gov/34674610/))
- Topical administration of Calendula provides weak evidence of effectiveness in acute and chronic wounds compared to standard treatments based on a narrative review of available trials. ([Wounds, 2008](https://pubmed.ncbi.nlm.nih.gov/25941793/))

## Why other moisturizers fit skin with dark spots better

- Treatment with ascorbyl glucoside-arginine complex lotion significantly decreased pigmentation scores and melanin index while increasing lightness in solar lentigos of Japanese females compared to placebo over 24 weeks. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/39769217/))

## What reviewers say

Users frequently report this ampoule delivers a desirable 'glass skin' effect, significantly enhancing hydration, radiance, and skin texture. Many also observe a reduction in fine lines and a strengthened skin barrier. However, some users find the price high for the quantity provided, and a few mention the texture can be too heavy for oily skin types or during warmer months.

- Liked: Deep hydration (mostly mentioned)
- Liked: Glow and radiance (often mentioned)
- Liked: Smoother texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Soothing and repair (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: No results (rarely noted)
- Disliked: Sticky or heavy (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does REJURAN Dual Effect work for skin with dark spots?

This treatment works moderately well for your skin, as it provides helpful hydration and soothing benefits but lacks targeted ingredients to address dark spots. A product of this type for skin with dark spots needs brightening ingredients like niacinamide and arbutin to effectively fade discoloration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum contains niacinamide and arbutin, which help brighten dark spots and even out skin tone. To work best for dark spots, a product of this type needs targeted brightening ingredients and effective pigmentation-fading actives like vitamin C or licorice extract.

### What does Blackberry Leaf Extract do for skin with dark spots?

Blackberry leaf extract helps fade dark spots by targeting excess skin pigment. This plant-based ingredient may improve uneven skin tone safely with a low risk of irritation.
Sources: [The Journal of Investigative Dermatology. Symposium Proceedings, 2008](https://pubmed.ncbi.nlm.nih.gov/18369335/)

### What does Licorice Extract do for skin with dark spots?

Licorice extract helps fade dark spots and even out skin tone by slowing down the melanin production that causes discoloration. It is also very safe and gentle, making it unlikely to irritate even sensitive skin while brightening your complexion.
Sources: [Journal of Ethnopharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/40350048/), [Pigment Cell Research, 1998](https://pubmed.ncbi.nlm.nih.gov/9870547/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and before moisturizing, though it can also be used in the morning or twice a day. While it offers moderate hydration and soothing benefits, skin with dark spots needs targeted brightening ingredients like vitamin C or niacinamide to effectively fade discoloration.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment alongside retinol by applying it before your retinol product to help keep your skin calm and hydrated. Applying a barrier-supporting moisturizer helps reduce the irritation often caused by retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. While it offers moderate hydration and soothing benefits, skin with dark spots needs targeted brightening ingredients like vitamin C, alpha arbutin, or tranexamic acid for best results.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This moisturizing treatment is unlikely to clog pores or cause breakouts for skin with dark spots because it is safe for normal skin and avoids harsh substances. However, since it lacks targeted ingredients for dark spots, this skin needs a product with brightening ingredients like vitamin C or niacinamide to effectively fade discoloration.

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is safe to use on the body and around the eyes, though the eyelid skin is among the thinnest areas and needs gentle care. It helps keep skin soft and smooth, but skin with dark spots needs a product that includes targeted brightening ingredients like vitamin C, kojic acid, or retinoids.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ca/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/dark-spots) — High fit — CA$25.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/dark-spots) — High fit — CA$21.81 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/dark-spots) — Average fit — CA$37.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/ca/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — CA$23.99 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/dark-spots) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Amazon.ca: CA$76.50 (https://www.amazon.ca/dp/B08BZCY3Y1?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Sephora: CA$76.00 (https://www.sephora.com/ca/en/product/rejuran-dual-effect-ampoule-P527743?skuId=3036035)
Prices checked 17 Oct – 6 Nov 2026.

## Ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Blueberry Fruit Extract, Morus Nigra Fruit Extract, Peg-6, Glycerin, Water, Hyaluronic Acid, Niacinamide, Dipropylene Glycol, Butylene Glycol, 1,2-Hexanediol, Carbomer, Gerotine Hydrolyzed Dna, Hydrolyzed Dna, Xanthan Gum, Polysorbate 20, Adenosine, Tocopheryl Acetate, Bisabolol, Arbutin, Ethylhexylglycerin, Caprylyl Glycol, Hexylene Glycol, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide Np, Oleic Acid, Inulin Lauryl Carbamate, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- France: https://lovi.care/skincare/fr/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots (this page)
- Australia: https://lovi.care/skincare/au/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/rejuran/turnover-ampoule-dual-effect/for/dark-spots