# Pharma Développement A313 Vitamin A Retinol Cream for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Pharma Développement](https://lovi.care/skincare/ca/brands/pharma-developpement)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your normal skin due to retinyl acetate and retinyl propionate, which help minimize fine lines and wrinkles by promoting cell turnover.
- While providing general skincare benefits like hydration and cleansing, the formula's focus on cell turnover is not directly supportive of your primary concerns of redness and irritation.
- The product is safe for your sensitive skin, as it lacks prohibited or harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Retinyl Palmitate, Retinyl Acetate, Retinyl Propionate, Peg-4000, Polysorbate 80

## What the research says

- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- A combination of retinyl propionate and climbazole (RPC) resulted in significant improvement in aging attributes, including deep wrinkles and hyperpigmentation, with significantly less irritation compared to 0.1% retinol in 45 healthy Caucasian females with moderately photodamaged facial skin. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/28733999/))
- Exposure of mouse epidermal cell cultures to beta-retinyl acetate inhibited cellular proliferation, strongly reduced benz[a]anthracene-induced aryl hydrocarbon hydroxylase activity to 20% of controls, markedly decreased DNA binding of 7,12-dimethylbenz[a]anthracene, and significantly increased its binding to cellular protein. ([Chemico-biological Interactions, 1977](https://pubmed.ncbi.nlm.nih.gov/862128/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- Topical retinyl propionate cream produced no statistically significant differences compared to placebo for any clinical, histological, or profilometric parameters of skin photoageing in 80 subjects. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9894360/))
- A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/))
- Topical application of 20% 2-hydroxypropyl-beta-cyclodextrin in a polyethylene glycol formulation resulted in significantly more herpes labialis relapses compared to the vehicle control among 40 patients over 6 months. ([Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23816977/))
- Binary systems of trans-resveratrol with polyethylene glycol or beta-cyclodextrin enhanced its antioxidant activity and in vivo skin anti-aging effects compared to trans-resveratrol alone in human keratinocytes and volunteers. ([Drug Development and Industrial Pharmacy, 2014](https://pubmed.ncbi.nlm.nih.gov/23862976/))
- Topical application of 30% salicylic acid in polyethylene glycol effectively cleared comedones and papules in 436 patients with acne while causing no stinging, burning, edema, bleeding, or crusting. ([Dermatologic Surgery, 2008](https://pubmed.ncbi.nlm.nih.gov/18363720/))
- Hempseed or flaxseed oil-based lyotropic liquid crystals with the highest oil content and lecithin/Tween 80 mixture provided a 2-fold reduction in TEWL values and decreased skin erythema levels in healthy adult subjects compared to baseline. ([Acta Pharmaceutica, 2024](https://pubmed.ncbi.nlm.nih.gov/38815204/))
- Liquid crystalline emulsions formulated with camellia seed oil and four different surfactant combinations reduced transepidermal water loss and increased skin hydration without causing skin irritation, with the formulation containing Lecinol S-10 and Tween 80 demonstrating the best clinical results. ([Scientific Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/36918671/))
- The cytotoxic effect of sodium lauryl sulphate on normal human keratinocytes was significantly decreased when combined with cocamidopropyl betaine, Tween 20, and Tween 80 at concentrations well below the critical micelle concentration. ([Skin Pharmacology and Applied Skin Physiology, 2003](https://pubmed.ncbi.nlm.nih.gov/12677096/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Based on a very large amount of data, this French pharmacy favorite is celebrated for delivering radiant, smooth skin and reducing acne, with users frequently waking up to a glowing complexion. However, its thick, Vaseline-like consistency and initial itching are polarizing aspects. While many praise its hydrating and plumping effects, some find it too mild for significant anti-aging results.

- Liked: Incredible glow (mostly mentioned)
- Disliked: Intense itching (mostly mentioned)
- Liked: Smoother texture (often mentioned)
- Disliked: Greasy texture (often mentioned)
- Liked: Acne reduction (sometimes noted)
- Liked: Affordable price (sometimes noted)
- Liked: Occlusive hydration (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Application difficulty (rarely noted)
- Disliked: Pore clogging (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does A313 Retinol Cream work for sensitive skin?

Pharma Développement A313 Vitamin A Retinol Cream is an average fit for sensitive skin because its focus on cell turnover does not directly target redness and irritation. A product of this type needs soothing ingredients like niacinamide and snail secretion filtrate, along with potent antioxidants and hydrating components, to properly calm and protect sensitive skin.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/), [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/)

### Which ingredients make this cream a good fit for sensitive skin?

This cream is a safe choice for sensitive skin because it is free of harsh ingredients that cause irritation, though it does not actively target redness. Treatments that fit sensitive skin better need soothing ingredients like niacinamide and snail secretion filtrate, along with antioxidants and hydrating agents to calm the skin and keep it healthy.

### What does Retinyl Palmitate do for sensitive skin?

Retinyl palmitate helps improve fine lines, wrinkles, and texture, but for sensitive skin it requires careful testing because it may cause irritation. This skin type needs gentle, hydrating ingredients and barrier-repairing components to stay calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/), [International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34211271/)

### What does Retinyl Acetate do for sensitive skin?

Retinyl acetate helps improve skin texture and supports overall appearance while minimizing irritation for sensitive skin. Advanced delivery systems help enhance its stability and penetration so it remains gentle on delicate skin.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41062584/)

### Where does this cream go in a skincare routine for sensitive skin?

This treatment goes in your evening routine, applied after your soothing toner and before your moisturizer. Putting it at night helps keep your skin safe from sun exposure while it works.

### Can I use this cream with niacinamide, and in what order?

You can use this cream with niacinamide, applying the niacinamide first and letting it absorb before putting on this treatment. Combining them helps improve fine lines and wrinkles while keeping the skin calm.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/), [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/)

### How often should I use this cream?

You can use this treatment in your evening routine, starting just once a week to see how your skin reacts since it focuses on cell turnover rather than calming redness and irritation. Sensitive skin of this type needs gentle, hydrating ingredients and soothing formulas that reduce redness while still supporting a smooth, youthful look.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/), [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to cause purging, but it has a very greasy texture that may clog pores on sensitive skin. A product of this type needs a lightweight, soothing formula with calming ingredients to keep sensitive skin clear and comfortable.

## Alternatives for sensitive skin

- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — CA$33.98 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — CA$24.44 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/sensitive-skin) — High fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Sephora: CA$50.00 (https://www.sephora.com/ca/en/product/vitamin-pomade-P517655?skuId=2895134)
Prices checked 21 Oct 2026.

## Ingredients

Retinyl Acetate, Retinyl Propionate, Retinyl Palmitate, Peg-4000, Peg 400, Polysorbate 80
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin