# Pharma Développement A313 Vitamin A Retinol Cream for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Pharma Développement](https://lovi.care/skincare/ca/brands/pharma-developpement)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your oily skin due to the presence of multiple forms of retinol, which also provide seboregulation and keratolytic action to help manage oiliness.
- While the retinol complex addresses oiliness and fine lines, its primary focus is not on treating your acne, blemishes, and breakouts.
- The product is generally safe for your oily skin, with a low risk of irritation from the retinol ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Retinyl Palmitate, Retinyl Acetate, Retinyl Propionate, Peg-4000, Polysorbate 80

## What the research says

- Retinyl palmitate ethosomal hydrogel reduced non-inflammatory and total acne lesion counts significantly better than marketed tretinoin while improving tolerability with minimal skin irritation in patients with acne vulgaris. ([International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34211271/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/))
- Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate. ([Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/))
- Combining microneedling with 5% retinyl palmitate-loaded oleogel yielded modest scar reduction and good patient satisfaction in three female patients with atrophic acne scars, showing no significant differences compared to microneedling with placebo. ([Journal of Clinical Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/41899112/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical retinyl propionate cream produced no statistically significant differences compared to placebo for any clinical, histological, or profilometric parameters of skin photoageing in 80 subjects. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9894360/))
- Topical application of 20% 2-hydroxypropyl-beta-cyclodextrin in a polyethylene glycol formulation resulted in significantly more herpes labialis relapses compared to the vehicle control among 40 patients over 6 months. ([Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23816977/))
- Binary systems of trans-resveratrol with polyethylene glycol or beta-cyclodextrin enhanced its antioxidant activity and in vivo skin anti-aging effects compared to trans-resveratrol alone in human keratinocytes and volunteers. ([Drug Development and Industrial Pharmacy, 2014](https://pubmed.ncbi.nlm.nih.gov/23862976/))
- Topical application of 30% salicylic acid in polyethylene glycol effectively cleared comedones and papules in 436 patients with acne while causing no stinging, burning, edema, bleeding, or crusting. ([Dermatologic Surgery, 2008](https://pubmed.ncbi.nlm.nih.gov/18363720/))
- Hempseed or flaxseed oil-based lyotropic liquid crystals with the highest oil content and lecithin/Tween 80 mixture provided a 2-fold reduction in TEWL values and decreased skin erythema levels in healthy adult subjects compared to baseline. ([Acta Pharmaceutica, 2024](https://pubmed.ncbi.nlm.nih.gov/38815204/))
- Liquid crystalline emulsions formulated with camellia seed oil and four different surfactant combinations reduced transepidermal water loss and increased skin hydration without causing skin irritation, with the formulation containing Lecinol S-10 and Tween 80 demonstrating the best clinical results. ([Scientific Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/36918671/))
- The cytotoxic effect of sodium lauryl sulphate on normal human keratinocytes was significantly decreased when combined with cocamidopropyl betaine, Tween 20, and Tween 80 at concentrations well below the critical micelle concentration. ([Skin Pharmacology and Applied Skin Physiology, 2003](https://pubmed.ncbi.nlm.nih.gov/12677096/))

## Why other serums fit oily acne-prone skin better

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel provided significantly greater, synergistic efficacy and a faster onset of action compared with the vehicle, adapalene monotherapy, and benzoyl peroxide monotherapy in patients with acne vulgaris. ([The British Journal of Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/19466959/))
- Topical benzoyl peroxide 5% gel treatment improved acne severity, sebum, stratum corneum hydration, and transepidermal water loss, while significantly reducing microbial diversity and the prevalence of Cutibacterium in 33 patients with acne vulgaris. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34962033/))

## What reviewers say

Based on a very large amount of data, this French pharmacy favorite is celebrated for delivering radiant, smooth skin and reducing acne, with users frequently waking up to a glowing complexion. However, its thick, Vaseline-like consistency and initial itching are polarizing aspects. While many praise its hydrating and plumping effects, some find it too mild for significant anti-aging results.

- Liked: Incredible glow (mostly mentioned)
- Disliked: Intense itching (mostly mentioned)
- Liked: Smoother texture (often mentioned)
- Disliked: Greasy texture (often mentioned)
- Liked: Acne reduction (sometimes noted)
- Liked: Affordable price (sometimes noted)
- Liked: Occlusive hydration (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Application difficulty (rarely noted)
- Disliked: Pore clogging (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does A313 Retinol Cream work for oily acne-prone skin?

This cream works moderately well for oily skin by helping manage oiliness and fine lines, but it is not primarily focused on treating acne and breakouts. An ideal product for this skin type needs ingredients like niacinamide, propolis, benzoyl peroxide, or vitamin C to directly target blemishes while controlling oil and keeping the skin comfortable without irritation.
Sources: [International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34211271/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/)

### Which ingredients make this cream a good fit for oily acne-prone skin?

This cream fits your oily skin because it contains multiple forms of retinol, which help manage oiliness and fine lines with a low risk of irritation. However, because it does not target breakouts directly, oily acne-prone skin needs a treatment containing ingredients like niacinamide, propolis, benzoyl peroxide, or vitamin C to properly manage blemishes and excess oil.
Sources: [International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34211271/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/)

### What does Retinyl Palmitate do for oily acne-prone skin?

Retinyl palmitate helps manage acne-prone skin by reducing acne blemishes and spots while keeping skin irritation low. It works well for oily skin types because it supports normal skin cell turnover and helps keep pores clear, though this type of skin also needs ingredients that control excess oil and soothe inflammation.
Sources: [International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34211271/), [Biochimica Et Biophysica Acta, 2012](https://pubmed.ncbi.nlm.nih.gov/21914489/)

### What does Retinyl Acetate do for oily acne-prone skin?

Retinyl acetate helps clear oily acne-prone skin by improving ingredient delivery deep into pores while minimizing irritation. Advanced delivery systems carrying retinyl acetate enhance product stability and bioavailability to support wound healing and skin healing effectively.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41062584/)

### Where does this cream go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine after cleansing and toning, and before your moisturizer. It works well for oily skin by helping manage oiliness and fine lines, though oily acne-prone skin needs products containing targeted blemish-fighting ingredients to properly address breakouts.

### Can I use this cream with niacinamide, and in what order?

Yes, you can use this cream with niacinamide by applying niacinamide in your toner step before this treatment, or by using niacinamide in your morning routine while saving this cream for the evening. This combination helps manage oiliness and improves fine lines while keeping skin calm and comfortable.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/)

### How often should I use this cream?

You can use this treatment in your evening routine, applying it once a week at first and carefully building up frequency if your skin tolerates it well. This routine helps your skin adjust safely to the retinol ingredients while minimizing potential irritation. Oily acne-prone skin needs products with targeted blemish-fighting ingredients and oil-balancing agents to fully clear breakouts.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/)

### Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream works for your oily acne-prone skin, though other products fit it better because its multiple forms of retinol help manage oiliness rather than directly treating active breakouts. However, it may cause breakouts or purging for some users since its greasy texture can clog pores, and a product of this type needs lightweight or non-greasy ingredients to better keep pores clear.
Sources: [International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34211271/), [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/)

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Sephora: CA$50.00 (https://www.sephora.com/ca/en/product/vitamin-pomade-P517655?skuId=2895134)
Prices checked 21 Oct 2026.

## Ingredients

Retinyl Acetate, Retinyl Propionate, Retinyl Palmitate, Peg-4000, Peg 400, Polysorbate 80
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin