# Peter Thomas Roth Retinol Fusion PM Night Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Peter Thomas Roth](https://lovi.care/skincare/ca/brands/peter-thomas-roth)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for minimizing fine lines and wrinkles due to the presence of retinol, which promotes skin renewal, and provides general hydration benefits from squalane and bisabolol that are supportive for normal skin.
- The formulation is excellent for normal skin, with retinol regulating cell turnover and squalane and tocopheryl acetate providing emollient and antioxidant actions.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing bisabolol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Microencapsulated Retinol, Vitamins C, Squalane, Bisabolol, Cyclopentasiloxane

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Application of an alpha-bisabolol-containing cream produced a significant skin-lightening effect in pigmented skin compared to a vehicle control in the majority of female subjects after 8 weeks. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20642768/))
- The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate reduces UVB-induced PGE2, inflammatory cytokines, and mitochondrial superoxide in human epidermal keratinocytes. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38433250/))

## What reviewers say

Based on a very large amount of data, this retinol serum is highly regarded for its anti-aging effects, including smoothing fine lines and improving skin texture, with most users experiencing a radiant and refined complexion without irritation. Some users reported a lack of visible results or found the thin consistency and premium price point to be drawbacks.

- Liked: Non-irritating formula (mostly mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Smoother texture (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Radiant complexion (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Oily feel (rarely noted)
- Disliked: Thin consistency (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Peter Thomas Roth Retinol Fusion PM Night Serum work for mature skin?

Peter Thomas Roth Retinol Fusion PM Night Serum works decently for mature skin, helping to smooth fine lines with retinol while keeping skin soft with squalane and bisabolol. A product of this type needs high concentrations of potent antioxidants, peptides, and humectants that exceptionally target wrinkles and improve skin elasticity for mature skin.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this serum a good fit for mature skin?

Microencapsulated retinol helps smooth fine lines by encouraging skin renewal, while squalane and bisabolol keep the skin soft and calm. To best support mature skin, a product of this type needs high concentrations of potent anti-aging ingredients, powerful antioxidants, and deeply hydrating components that effectively target wrinkles while maintaining excellent safety and suitability.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Microencapsulated Retinol do for mature skin?

Microencapsulated retinol helps smooth fine lines and even out dark spots on mature skin while typically causing less irritation than standard retinol. It works gradually to improve the look of aging skin, though it may still cause mild dryness or flaking.
Sources: [Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/), [Clinical Interventions in Aging, 2006](https://pubmed.ncbi.nlm.nih.gov/18046911/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing fine lines and wrinkles while improving firmness and overall radiance. It supports the skin by boosting collagen production and providing antioxidant protection against daily damage.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening helps with simplicity and extra safety around sun exposure.

### Can I use this serum with niacinamide, and in what order?

You can use this serum with niacinamide by applying niacinamide first, letting it absorb, and then following with this serum. This type of skin needs ingredients that provide stronger anti-aging benefits and deeper hydration to effectively smooth fine lines and plump mature skin.

### How often should I use it?

Apply this treatment in the evening as part of your routine. This product of this type needs regular use to help smooth fine lines, alongside ingredients like concentrated retinoids and rich moisturizers to better support mature skin.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can it clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts on mature skin, but the retinol in it may cause some initial skin purging as it speeds up cell renewal. Because this product is only an average fit for mature skin, a routine for this skin type typically needs stronger anti-aging ingredients and richer moisturizers to better smooth fine lines.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for mature skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/mature-skin) — High fit — CA$27.99 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/mature-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Cyclopentasiloxane, Squalane, Water, Retinol, Tocopheryl Acetate, Ascorbyl Palmitate, Bisabolol, Lecithin, Potassium Phosphate, Pentylene Glycol, Polysorbate-20, Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin