# Perricone MD Rejuvenating Moisturizer for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Perricone MD](https://lovi.care/skincare/ca/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your dry skin, as glycerin and macadamia ternifolia seed oil provide essential hydration and support barrier resilience, while S-Palmitoylglutathione offers antioxidant benefits.
- While it addresses general hydration for dry or flaky skin, the lactic acid and parfum may pose a slight irritation risk for your sensitive skin.
- The product is generally safe for your skin, with a low potential for adverse reactions.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Tetrahexyldecyl Ascorbate, Ribose, Lactic Acid, Macadamia Ternifolia Seed Oil

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- Combining high-intensity focused ultrasound with a topical agent containing glutathione and hyaluronic acid significantly improves skin quality, fine wrinkles, hyperpigmentation, hydration, and brightness in female volunteers compared to the topical agent alone. ([The Journal of Dermatological Treatment, 2024](https://pubmed.ncbi.nlm.nih.gov/39326871/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))

## What reviewers say

This moisturizer is praised for its rich texture that plumps, firms, and smooths aging or dry skin without greasiness. Many users report reduced fine lines and improved radiance. Some users experienced product pilling or sensitivity to the fragrance.

- Liked: Deeply hydrating (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Non-greasy formula (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Product pilling (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)
- Disliked: White cast (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Rejuvenating Moisturizer work for dry sensitive skin?

This moisturizer works moderately well for dry skin, as its ingredients provide essential hydration and support skin barrier resilience, though the lactic acid and added fragrance may pose a slight irritation risk for sensitive skin. A product of this type needs soothing, highly effective ingredients that provide deep hydration and nourishment without any risk of irritation, along with moisturizing agents and barrier-supporting ingredients that contain no allergens.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### Which ingredients make this cream a good fit for dry sensitive skin?

Glycerin and macadamia oil help this cream fit your dry skin by providing essential moisture and supporting your skin barrier. To work well for sensitive skin of this type, a moisturizer needs soothing, deeply nourishing ingredients that deliver strong hydration without any risk of irritation or added allergens.

### What does Acyl-Glutathione do for dry sensitive skin?

Acyl-Glutathione helps protect dry sensitive skin against environmental and oxidative stress while improving overall moisture and smoothness. It is unlikely to cause irritation and supports a calm, healthy look.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Vitamin C do for dry sensitive skin?

Vitamin C helps make dry, sensitive skin feel softer and calmer while improving firmness and reducing redness. Studies show that gentle forms of vitamin C can improve skin hydration and elasticity safely without causing irritation.
Sources: [Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38397772/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/)

### Where does it go in a skincare routine for dry sensitive skin?

For your dry sensitive skin, apply this moisturizing treatment in the evening as a treatment step before your moisturizer. A product of this type needs soothing ingredients, gentle hydrators, and fragrance-free formulas to comfort dry skin without causing irritation.

### Can I use this cream with retinol, and in what order?

You can use this treatment alongside retinol by applying your retinol first, letting it absorb, and then following with this cream at night. Because your skin is sensitive, starting this combination slowly helps you check for any irritation from the lactic acid and added fragrance. Dry and sensitive skin types need a deeply nourishing treatment packed with soothing ingredients and extra barrier support to comfortably handle active ingredients like retinol.

### How often should I use it?

This moisturizer works for your dry sensitive skin, but the lactic acid and added fragrance may cause a slight irritation risk, so you may want to start using it just once a week. If your skin feels comfortable and tolerates it well, you can gradually increase how often you apply it. A product for this skin type needs gentle, hydrating ingredients like glycerin and plant oils to soothe dryness without harsh acids or perfumes that can upset sensitive areas.

### Can this cream clog pores, cause breakouts or purging for dry sensitive skin?

This cream is unlikely to clog pores or cause breakouts for dry sensitive skin, though it may occasionally cause slight irritation. To truly thrive, dry sensitive skin needs soothing, fragrance-free hydration and barrier-strengthening ingredients without harsh acids or added perfumes.

### Can I use it around the eyes or on my body?

This moisturizer is generally safe for the skin, though you should be cautious around the eyes since that area is much thinner and more delicate than the rest of the body. While it helps keep skin soft and smooth, a product for dry sensitive skin needs rich nourishing oils and gentle calming ingredients without any added fragrance to avoid irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-sensitive-skin) — Superior fit — CA$30.98 at Amazon
- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/dry-sensitive-skin) — Superior fit — CA$103.73 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/ca/p/the-ordinary/natural-moisturizing-factors-ha/for/dry-sensitive-skin) — Superior fit — CA$16.20 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — CA$20.19 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/ca/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — CA$38.00 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin