# Perricone MD Rebalancing Elixir for sensitive skin

**Lovi Fit: Superior fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Perricone MD](https://lovi.care/skincare/ca/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for sensitive skin.

## Why this fit

- Excellent for your normal, sensitive skin, this formula utilizes capryloyl glycine and sodium bicarbonate to effectively mattify and control oil production, aligning with your skin type's needs.
- Cannabidiol and Ganoderma Lucidum Stem Extract offer moderate soothing benefits for your redness and irritation goals, while Sodium PCA and Glycerin provide essential hydration.
- The product is safe for your sensitive skin, as it contains no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/sensitive-skin): Superior (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/oily-acne-prone-skin): High

## Key ingredients

Cannabidiol, Mushroom Complex, Cherimoya Fruit Extract, Capryloyl Glycine, Sodium Pca

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of an anti-aging gel containing EPA and CBD reduced inflammatory agents, decreased crow's feet and fine line wrinkle volume, reduced the subepidermal low-echogenic band by 8.8%, and increased skin hydration by 31.2% and elasticity by 25.6% in 33 participants over 56 days compared to baseline. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/))
- Menstrual pads containing sodium bicarbonate caused no clinical signs or subclinical vulvar skin irritant reactions in 50 healthy women after 24 hours of patch testing. ([The Journal of Reproductive Medicine, 1991](https://pubmed.ncbi.nlm.nih.gov/1658321/))
- Topical nano-cannabidiol cream reduced UV-A-induced epidermal hyperplasia, nuclear DNA base lesions, and mitochondrial DNA deletions compared with vehicle in nineteen participants. ([Journal of the American Academy of Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39025264/))
- Daily application of a novel retinol and cannabidiol combination topical improved global skin quality across 13 domains, including visible pores, dehydration, surface roughness, and static and dynamic wrinkles, in 10 patients with facial skin imperfections. ([Aesthetic Surgery Journal. Open Forum, 2022](https://pubmed.ncbi.nlm.nih.gov/35274096/))
- Topical application of carboxymethylcellulose/chitosan hydrogel loaded with cannabidiol reduced inflammation and increased collagen production in radiation-combined wound skin injury in mice. ([Phytomedicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40318533/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of a formulation containing capryloyl glycine 4% significantly decreased hair density, median hair length, and terminal hair density on the forearms compared to placebo in female patients with hypertrichosis after 120 days. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33347705/))
- A novel natural carrier-free assembled gel composed of sodium pyrrolidone carboxylate and baicalin alleviates UVB-induced skin photodamage by scavenging reactive oxygen species, protecting mitochondria, restoring oxidative homeostasis, inhibiting inflammatory responses, and regulating collagen-related proteins. ([Biomaterials Advances, 2026](https://pubmed.ncbi.nlm.nih.gov/41129958/))

## What reviewers say

Most users find it provides lightweight hydration that absorbs quickly without feeling heavy, leading to improved skin balance and texture. A moderate number of users feel the product is too expensive for the results, and a low number dislike the natural scent or do not see dramatic anti-aging effects.

- Liked: Soothes sensitive skin (mostly mentioned)
- Liked: Lightweight hydration (often mentioned)
- Liked: Good for layering (sometimes noted)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Expensive for results (sometimes noted)
- Disliked: Not a miracle worker (rarely noted)
- Disliked: Product availability issues (rarely noted)
- Disliked: Unpleasant natural scent (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Perricone MD Rebalancing Elixir one of the best fits for sensitive skin?

This product is an exceptional fit because it uses capryloyl glycine and sodium bicarbonate to control oil and shine, while cannabidiol and mushroom extracts help calm redness and irritation. It also delivers essential hydration with sodium PCA and glycerin, and it is unlikely to cause irritation since it avoids harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this elixir a good fit for sensitive skin?

This elixir is a great fit for sensitive skin because it uses capryloyl glycine and sodium bicarbonate to control oil, while cannabidiol and mushroom extracts help calm redness and irritation. Additionally, sodium PCA and glycerin provide essential hydration to keep the skin comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Cannabidiol do for sensitive skin?

Cannabidiol helps calm sensitive skin by reducing inflammation and easing redness. It is unlikely to irritate because it generally has a very safe profile on human skin cells.
Sources: [The Journal of Pharmacology and Experimental Therapeutics, 2018](https://pubmed.ncbi.nlm.nih.gov/29632236/), [Journal of Cannabis Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40818974/)

### What does Mushroom Complex do for sensitive skin?

Mushroom Complex helps calm sensitive skin by lowering inflammation and reducing redness. Its antioxidant properties also protect delicate skin from daily stress and irritation.
Sources: [Archives of Dermatological Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40057933/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24002162/)

### Where does this elixir go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after cleansing and a soothing toner, and before your moisturizer. It is also suitable for weekly use following an enzyme powder and a nourishing mask.

### Can I use this elixir with retinol, and in what order?

Yes, you can use this elixir with retinol by applying the elixir after your toner and before your moisturizer in your evening routine. It contains soothing cannabidiol and mushroom complex which help keep your sensitive skin calm, while glycerin provides essential hydration to offset any dryness from retinol.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this elixir?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. It is safe for your sensitive skin and is unlikely to cause irritation.

### Can this elixir clog pores, cause breakouts or purging for sensitive skin?

This elixir is unlikely to clog pores or cause breakouts for sensitive skin because it is free of harsh ingredients and uses gentle, hydrating elements like glycerin and sodium PCA. It helps keep skin calm and balanced without triggering irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this elixir fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/sensitive-skin) — Superior fit — CA$22.73 at Amazon
- [Dr. Ceuracle Tea Tree Purifine 95 Essence](https://lovi.care/skincare/ca/p/dr-ceuracle/tea-tree-purifine-95-essence/for/sensitive-skin) — High fit — CA$48.14 at Amazon
- [Aestura A-Cica 365 Blemish Calming Serum](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin) — High fit — CA$52.00 at Sephora

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, 1,2-Hexanediol, Sodium Pca, Triethyl Citrate, Propanediol, Capryloyl Glycine, Glycerin, Annona Cherimola Fruit Extract, Cannabidiol, Ganoderma Lucidum Stem Extract Mushroom Stem Extract, Grifola Frondosa Fruiting Body Extract, Sodium Bicarbonate, Caprylhydroxamic Acid, Sodium Hydroxide, Citric Acid, Cannabis Sativa Glycereth-8 Esters Seed Oil, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sodium Citrate, Lentinus Edodes Mycelium Extract, Sodium Dehydroacetate, Phenylpropanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/rebalancing-elixir/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/rebalancing-elixir/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/rebalancing-elixir/for/sensitive-skin
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- Italy: https://lovi.care/skincare/it/p/perricone-md/rebalancing-elixir/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/rebalancing-elixir/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/perricone-md/rebalancing-elixir/for/sensitive-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/rebalancing-elixir/for/sensitive-skin