# Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Perricone MD](https://lovi.care/skincare/ca/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for dry skin.

## Why this fit

- Excellent suitability for your dry skin is provided by the high concentrations of sodium hyaluronate, sodium hyaluronate crosspolymer, and sodium acetylated hyaluronate, which offer superior moisture retention, complemented by squalane and ceramide np for emollient action and barrier repair.
- Niacinamide and acetyl glucosamine further enhance skin hydration and texture, addressing your dry or flaky skin concerns effectively.
- The product is safe for your skin due to the absence of harsh ingredients and the inclusion of soothing components like glycerin and sodium hyaluronate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Niacinamide, Squalane, Ceramide Np, Acetyl Glucosamine

## What the research says

- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion. ([International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Liposomes containing N-acetyl glucosamine prepared using the fusion method significantly increased skin moisture content compared to empty liposomes in human volunteers over a 5-hour period. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23725302/))

## What reviewers say

Users consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.

- Liked: Deep hydration (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Plumps fine lines (often mentioned)
- Liked: Smooths texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Scent (rarely noted)
- Disliked: Sticky feel (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD High Potency Hyaluronic Intensive Hydrating Serum one of the best fits for dry skin?

This serum is one of the best fits because it features high concentrations of sodium hyaluronate for superior moisture retention, along with squalane and ceramide np to smooth and repair the skin barrier. Niacinamide and acetyl glucosamine further help improve texture and address dry or flaky skin concerns.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for dry skin because it packs high levels of sodium hyaluronate forms for deep moisture retention, alongside squalane and ceramide NP to repair your skin barrier and smooth flaky areas. Niacinamide and acetyl glucosamine also help boost hydration and improve overall skin texture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine after cleansing and before moisturizing. Using it at night helps keep things simple and gives extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to keep your dry skin soft and hydrated, followed by your retinol. Using a barrier-supporting moisturizer with ingredients like ceramides and hyaluronic acid helps reduce the dryness and flaking that often come with retinol use.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You should use this treatment in your evening routine. Daily application helps improve skin moisture and texture while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin due to its safe ingredients and the absence of heavy or harsh components. It helps keep your skin feeling soft and smooth without triggering irritation.

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes and on the body because its hydrating ingredients like sodium hyaluronate and glycerin are gentle and safe for delicate skin areas. Regular use helps keep thin skin and drier body spots soft and well-moisturized without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/dry-skin) — High fit — CA$21.81 at Amazon
- [Numbuzin No.2 Protein 43% Creamy Serum](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-skin) — High fit — CA$28.99 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/ca/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/dry-skin) — High fit — CA$40.50 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — CA$20.19 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/ca/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — CA$27.99 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/ca/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — CA$38.00 at Amazon

## Where to buy

- Shoppers Drug Mart: CA$203.00 (https://www.shoppersdrugmart.ca/perricone-md-high-potency-hyaluronic-intensive-hydrating-serum/p/BB_651473713067?variantCode=651473713067)
Prices checked 15 Oct 2026.

## Ingredients

Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin (this page)
- Australia: https://lovi.care/skincare/au/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin