# Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Perricone MD](https://lovi.care/skincare/ca/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few moisturizers fit it even better.

## Why this fit

- Excellent suitability for your dry skin is provided by glycerin, linum usitatissimum seed oil, and macadamia ternifolia seed oil, which offer humectant and emollient actions to combat dryness and flakiness.
- Palmitoyl glycine and S-palmitoylglutathione further enhance moisturizing and antioxidant benefits, supporting skin elasticity and providing relevant benefits for your dry or flaky skin.
- The product is safe for your dry skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Tetrahexyldecyl Ascorbate, Lactic Acid, Macadamia Ternifolia Seed Oil, Vitamin F Blend

## What the research says

- Palmitoyl glycine and cocoyl alanine demonstrated complementary anti-aging properties and superior anti-wrinkle efficacy compared to a market reference ingredient in Caucasian women. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19732187/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9692305/))
- Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face. ([The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29344315/))
- Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin. ([Biological & Pharmaceutical Bulletin, 2004](https://pubmed.ncbi.nlm.nih.gov/15056874/))

## What reviewers say

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Pleasant texture (often mentioned)
- Disliked: Expensive price (often mentioned)
- Liked: Improves radiance (sometimes noted)
- Disliked: Limited wrinkle results (sometimes noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD Rejuvenating Moisturizer a great fit for dry skin?

This moisturizer is a great fit because glycerin, flaxseed oil, and macadamia seed oil work to combat dryness and flakiness. It is safe for your skin with no harsh ingredients, and ingredients like acyl-glutathione help support elasticity.

### Which ingredients make this cream a good fit for dry skin?

Glycerin, linseed oil, and macadamia oil make this cream a great fit for dry skin by drawing in moisture and softening flaky areas. Ingredients like Acyl-Glutathione and vitamin F blend add extra nourishment and antioxidants to help support skin elasticity.

### What does Acyl-Glutathione do for dry skin?

Acyl-glutathione helps protect dry skin by boosting antioxidant defenses and supporting moisture levels. It is unlikely to irritate dry skin and may help keep it feeling soft and smooth.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/)

### What does Vitamin C do for dry skin?

Vitamin C helps keep dry skin hydrated and makes it feel soft and smooth. Daily use may also improve overall skin texture and brightness over time.
Sources: [Photochemistry and Photobiology, 2021](https://pubmed.ncbi.nlm.nih.gov/33529350/), [Skin Research and Technology, 2008](https://pubmed.ncbi.nlm.nih.gov/19159387/)

### Where does this cream go in a skincare routine for dry skin?

This cream is applied in the morning after a hydrating toner and before your sunscreen, and in the evening as the final step of your routine. Using a daily moisturizer helps improve visual dryness and overall skin comfort for dry skin.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying the treatment after your retinol has fully absorbed, or by using retinol in the evening and this cream during the day. This routine helps keep dry skin smooth and comfortable while keeping the risk of irritation very low.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This moisturizing treatment is well suited for daily use to combat dryness and keep your dry skin soft and smooth. Applying it regularly helps improve skin moisture and barrier function while remaining safe and gentle.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for dry skin?

This cream is unlikely to clog pores or cause breakouts on dry skin, as it has a safe profile with no harsh ingredients that typically trigger irritation. Glycerin and nourishing seed oils help keep your skin smooth and calm without heavy buildup.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is well-suited for the body, but because the skin around the eyes is much thinner than on other body regions, you should use care if applying it there to avoid potential sensitivity. Its rich formula helps combat dryness and flakiness on dry skin without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — CA$30.98 at Amazon
- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/dry-skin) — Superior fit — CA$103.73 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/ca/p/the-ordinary/natural-moisturizing-factors-ha/for/dry-skin) — Superior fit — CA$16.20 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — CA$20.19 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/ca/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — CA$27.99 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/ca/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — CA$38.00 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin (this page)
- Australia: https://lovi.care/skincare/au/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-rejuvenating-moisturizer/for/dry-skin