# Perricone MD Cold Plasma Plus+ for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Perricone MD](https://lovi.care/skincare/ca/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your dry and flaky skin, as Glycerin and Sodium Hyaluronate provide essential hydration, while Helianthus Annuus Seed Oil and Echium Plantagineum Seed Oil offer emollient action to combat dryness.
- The presence of Tetrahexyldecyl Ascorbate and Acetyl Hexapeptide-8 contributes to smoothing texture and minimizing fine lines, offering general skincare improvements.
- The product is safe for your dry and sensitive skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid Ester, Copper Tripeptide, Acetyl Hexapeptide-8, Omega 3, Glycolic Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))

## Why other serums fit dry sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))

## What reviewers say

Based on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.

- Disliked: Unpleasant scent (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: High price tag (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Increases radiance (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Cold Plasma Plus+ work for dry sensitive skin?

This product works moderately well for dry and sensitive skin, providing basic hydration and smoothing texture without causing irritation. Treatments that fit this skin better need deep-acting hydrators, nourishing oils, and barrier-protecting ingredients that lock in moisture and soothe dryness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this treatment a good fit for dry sensitive skin?

Glycerin, Sodium Hyaluronate, and seed oils make this treatment a good fit by bringing essential moisture and keeping your skin soft and smooth. To work best for dry sensitive skin, a treatment of this type needs rich hydrating and nourishing components that lock in moisture and support the skin barrier without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Ascorbic Acid do for dry sensitive skin?

Ascorbic acid helps smooth fine lines and improve elasticity in dry, sensitive skin while being safe and well-tolerated. It is unlikely to cause irritation when used properly, making it a good choice for keeping reactive skin looking firm and radiant.
Sources: [Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38397772/)

### What does Copper Tripeptide do for dry sensitive skin?

Copper Tripeptide helps soothe and calm dry, sensitive skin by supporting tissue healing and skin renewal. This ingredient may also improve firmness and reduce visible redness as skin recovers.
Sources: [Journal of Biomaterials Science. Polymer Edition, 2008](https://pubmed.ncbi.nlm.nih.gov/18644225/), [International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/29986520/)

### Where does this treatment go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after your toner and before your moisturizer. It is unlikely to irritate your skin, but a product of this type for dry and sensitive skin needs extra soothing hydrators and nourishing plant oils to better lock in moisture and comfort the skin.

### Can I use this treatment with niacinamide, and in what order?

You can use this treatment alongside niacinamide by applying niacinamide first and following with this product once it absorbs. This product is unlikely to cause irritation on your skin, but to care properly for dry sensitive skin, it needs extra soothing and deep hydrating ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### How often should I use this treatment?

You can use this treatment in your evening routine once a week to start, and carefully increase the frequency if your skin tolerates it well. Nonprescription topical treatments generally serve as a low-risk intervention when added gradually to a routine.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this treatment clog pores, cause breakouts or purging for dry sensitive skin?

This treatment is unlikely to clog pores or cause breakouts for dry sensitive skin, as it contains no heavy oils or ingredients typically known to trigger acne. Because this skin needs extra moisture and gentle soothing care, a product of this type works best when it includes rich plant oils and hydrating ingredients that relieve flakiness without irritation.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry sensitive skin

- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ca/p/kravebeauty/great-barrier-relief/for/dry-sensitive-skin) — High fit — CA$40.00 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/dry-sensitive-skin) — High fit — CA$14.40 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-sensitive-skin) — High fit — CA$22.49 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — CA$20.19 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/ca/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — CA$38.00 at Amazon

## Where to buy

- Amazon.ca: CA$196.52 (https://www.amazon.ca/dp/B0FWHBTQYK?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Shoppers Drug Mart: CA$203.00 (https://www.shoppersdrugmart.ca/perricone-md-cold-plasma-plus-advanced-hydrating-complex/p/BB_651473714682?variantCode=651473714682)
Prices checked 10 Oct – 3 Nov 2026.

## Ingredients

Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin