# Perricone MD Cold Plasma Plus+ for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Perricone MD](https://lovi.care/skincare/ca/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as tetrahexyldecyl ascorbate and acetyl hexapeptide-8 work to smooth texture and minimize fine lines, though glycerin and sodium hyaluronate provide hydration that is not the primary concern for your oily shine.
- The formula is safe for your combination skin, lacking harsh ingredients that could cause irritation.
- While it offers general skincare benefits, the ingredients are not specifically targeted to address your main goal of managing oily shine.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid Ester, Copper Tripeptide, Acetyl Hexapeptide-8, Omega 3, Glycolic Acid

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.

- Disliked: Unpleasant scent (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: High price tag (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Increases radiance (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Cold Plasma Plus+ work for combination skin?

Perricone MD Cold Plasma Plus+ offers moderate suitability for your combination skin, smoothing texture and minimizing fine lines, though its hydration is not the primary focus for managing oily shine. A treatment for this skin needs ingredients like niacinamide, propolis, and zinc PCA to regulate oiliness and enhance radiance without irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Which ingredients make this treatment a good fit for combination skin?

Tetrahexyldecyl ascorbate and acetyl hexapeptide-8 help smooth texture and minimize fine lines on combination skin. To truly suit this skin type, a product of this type needs ingredients like niacinamide and zinc PCA that regulate oiliness and manage oily shine.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### What does Ascorbic Acid do for combination skin?

Ascorbic acid helps brighten dark spots and protect combination skin from daily environmental damage. It also provides antioxidant support, which may help keep the skin looking even and healthy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39376788/), [Acta Dermato-venereologica, 1996](https://pubmed.ncbi.nlm.nih.gov/8869680/)

### What does Copper Tripeptide do for combination skin?

Copper Tripeptide helps support firm, smooth skin and is generally gentle enough for combination skin types. It works to boost collagen and repair skin, though a formula meant for this skin type also needs balanced hydration to keep dry patches comfortable and oily areas clear.
Sources: [International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/29986520/), [FEBS Letters, 1988](https://pubmed.ncbi.nlm.nih.gov/3169264/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in your evening routine, as treatments with active ingredients are usually used at night for simplicity and extra safety around sun exposure. A treatment for your combination skin needs ingredients that help balance oily shine while smoothing texture.

### Can I use this treatment with niacinamide, and in what order?

Yes, you can use this treatment with niacinamide by applying niacinamide first and following with this product after it absorbs. A product of this type for combination skin needs lightweight, oil-balancing ingredients that help control shine while keeping the skin smooth and hydrated.

### How often should I use this treatment?

This treatment fits into your evening routine once a week to start, as products with exfoliating acids need gradual introduction to keep skin calm. If your skin handles it well, you may carefully use it more often. Combination skin needs ingredients that help balance oil and shine without weighing the skin down.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/)

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to clog pores or cause breakouts for your combination skin, as it has a safe formula without harsh ingredients that typically cause irritation. However, because combination skin needs a treatment that specifically targets oily shine, this type of product works best when it also includes ingredients that control excess oil and balance the skin.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$196.52 (https://www.amazon.ca/dp/B0FWHBTQYK?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Shoppers Drug Mart: CA$203.00 (https://www.shoppersdrugmart.ca/perricone-md-cold-plasma-plus-advanced-hydrating-complex/p/BB_651473714682?variantCode=651473714682)
Prices checked 10 Oct – 3 Nov 2026.

## Ingredients

Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/combination-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/combination-skin