# Perricone MD Cold Plasma Plus+ Sub-D/Neck for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Perricone MD](https://lovi.care/skincare/ca/brands/perricone-md)
Category: [Sunscreens and SPF moisturizers](https://lovi.care/skincare/ca/best/sunscreens)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few sunscreens fit it even better.

## Why this fit

- Excellent for your normal skin, this formula leverages niacinamide and tetrahexyldecyl ascorbate to effectively address pigmentation concerns and provide antioxidant protection. These ingredients work synergistically to brighten your complexion and support overall skin health.
- The inclusion of ethylhexyl methoxycrylene offers robust UV protection, further enhancing the product's benefits for maintaining even skin tone.
- Safety is well-managed, with bisabolol providing soothing properties and an absence of harsh or irritating ingredients, ensuring a gentle experience for your normal skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-acne-prone-skin): High

## Key ingredients

Dmae, Niacinamide, Tetrahexyldecyl Ascorbate, Acetyl Tetrapeptide-9, Glycerin

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo. ([American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/))
- A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE. ([Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/))
- A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties. ([Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, users frequently report visible improvements in skin texture and firmness along the jawline and neck, describing the skin as smoother and more hydrated. A significant number of reviewers consistently complain about a strong, unpleasant scent often compared to pickles or fish, and some experience issues with the product pilling under makeup.

- Disliked: Unpleasant smell (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Visibly tightens and firms (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Liked: Lightweight and absorbent (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: Pilling or flaking (rarely noted)

## How to apply

- Use this moisturizing sunscreen AM daily to protect your normal skin and fight dark spots.
- Apply this product as the final step of your morning routine after your moisturizer.
- Gently spread a coin-sized amount evenly over your face, avoiding rough rubbing.
- Apply this product on clean, dry skin for the best coverage and protection.
- Avoid the sensitive eye area and reapply every two hours when outdoors.
- Video: https://storage.pora.ai/53e9a436d82fca2a189dd08aa21de2fd.mp4

## Questions and answers

### What makes Perricone MD Sub-D/Neck a great fit for skin with dark spots?

This product is a great fit for skin with dark spots because it uses niacinamide and tetrahexyldecyl ascorbate to brighten dark spots and protect against the sun. These ingredients help fade uneven color while keeping your skin calm and comfortable.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this cream a good fit for skin with dark spots?

This cream is a great fit for skin with dark spots because it includes niacinamide and tetrahexyldecyl ascorbate, which help brighten your complexion and fade pigment intensity. Niacinamide significantly decreases hyperpigmentation by suppressing pigment transfer, while tetrahexyldecyl ascorbate targets photoaging and dark spots with daily use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does DMAE do for skin with dark spots?

DMAE does not target dark spots, as it is mainly used to help firm aging skin and smooth the look of fine lines. Skin with dark spots needs brightening ingredients like vitamin C or niacinamide to help fade discoloration and even out skin tone.

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this cream go in a skincare routine for skin with dark spots?

This cream goes in the morning routine as a moisturizer and sunscreen after your hydrating toner. It helps brighten your complexion and maintain an even skin tone while providing robust UV protection.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Can I use this cream with retinol, and in what order?

You can use this cream in your morning routine before your sunscreen, but you should apply your retinol at night instead. Using this product during the day helps brighten dark spots with ingredients like niacinamide and vitamin C while protecting your skin from UV rays.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### How often should I use this cream?

This moisturizing spf is a great fit to use daily in your morning routine. Using it regularly helps brighten your complexion, fade dark spots, and protect your skin from the sun.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for skin with dark spots?

This cream is unlikely to cause breakouts or clog pores, as it avoids harsh or irritating ingredients and features a gentle formula well-suited for your skin. It does not contain active ingredients that speed up cell turnover, so it will not cause purging.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

## Alternatives for skin with dark spots

- [innisfree Daily Sensitive Sunscreen](https://lovi.care/skincare/ca/p/innisfree/daily-sensitive-sunscreen/for/dark-spots) — High fit — CA$24.50 at Amazon
- [Eucerin Sun Fluid Anti-Age SPF 50](https://lovi.care/skincare/ca/p/eucerin/photoaging-control-sun-fluid-spf-50/for/dark-spots) — High fit — CA$32.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/ca/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — CA$23.99 at Amazon
- Moisturizer: [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/ca/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/dark-spots) — High fit — CA$98.99 at Amazon

## Where to buy

- Shoppers Drug Mart: CA$203.00 (https://www.shoppersdrugmart.ca/perricone-md-cold-plasma-plus-sub-d-neck/p/BB_651473706816?variantCode=651473706816)
Prices checked 10 Oct 2026.

## Ingredients

Water, Dimethicone, Cyclopentasiloxane, Glycerin, Niacinamide, Ethylhexyl Methoxycrylene, Pentylene Glycol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyester-8, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Tetrahexyldecyl Ascorbate, Thioctic Acid, Acetyl Tetrapeptide-9, Diethylhexyl Syringylidenemalonate, Hydrogenated Lecithin, Bisabolol, Xanthan Gum, Hydrogenated Phosphatidylcholine, Mannitol, Benzyl Alcohol, Stearic Acid, Isohexadecane, Polysilicone-11, Polysorbate 60, Sorbitan Isostearate, Caprylic Capric Triglyceride, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Aluminum Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots (this page)
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots