# PCA SKIN Rejuvenating Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [PCA SKIN](https://lovi.care/skincare/ca/brands/pca-skin)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate skin rejuvenation for your combination skin due to gluconolactone and niacinamide, which gently exfoliate and improve skin tone, though they do not specifically target oily shine.
- Glycerin and bisabolol provide general hydration and soothing benefits, supporting your skin's overall health without specialized oil control for your oily areas.
- The product is safe for your combination skin, with no risks of irritation from harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glutathione, Squalane, Epigallocatechin Gallate, Aloe Barbadensis Leaf Juice

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction. ([Journal of Clinical and Diagnostic Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28384900/))
- Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo. ([Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

This product is highly praised for improving skin texture, reducing fine lines, and providing a radiant glow. Users frequently mention its lightweight, fast-absorbing formula. Some users with sensitive skin find the alcohol-heavy base to be drying or irritating.

- Liked: Improves radiance (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Refreshing experience (sometimes noted)
- Disliked: Drying formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Irritating ingredients (rarely noted)
- Disliked: Lack of results (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does PCA SKIN Rejuvenating Serum work for combination skin?

This serum works moderately well for combination skin by offering gentle exfoliation and general hydration, though it does not specifically target oily shine. To work best for this skin type, a product needs ingredients like niacinamide and zinc PCA that provide significant benefits for managing oily shine while maintaining adequate hydration without overwhelming oilier areas.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for combination skin?

Gluconolactone and niacinamide make this serum work for combination skin by gently smoothing and evening out skin tone, while glycerin and bisabolol help keep skin comfortable and hydrated. To be a top fit for combination skin, a treatment of this type needs targeted ingredients like niacinamide and zinc PCA to manage oily shine without overwhelming drier areas.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Glutathione do for combination skin?

Glutathione helps brighten sun-exposed areas and reduce dark spots for combination skin, while also improving moisture and smoothness. It is unlikely to cause irritation and maintains a safe profile for regular use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [International Journal of Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39444151/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in your evening routine, applied after cleansing and before your moisturizer. Treatments with active ingredients are placed at night for simplicity and extra safety around sun exposure, though some may also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first and following with your retinol. This product is safe for your skin with no risks of irritation from harsh ingredients.

### How often should I use this serum?

This treatment goes into your evening routine once a week to start, and if your skin feels comfortable, you may carefully use it more often. Nonprescription treatments like this serve as a low-risk mainstay for skin rejuvenation, though combination skin needs added ingredients to control oily shine.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for your combination skin, as it has a safe profile with no harsh ingredients that typically trigger irritation. Combination skin needs targeted oil control and balancing ingredients to keep shiny areas clear while staying hydrated.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (sd alcohol 40-b).

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Sd Alcohol 40-B, Glycerin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Gluconolactone, Polysorbate 20, Bisabolol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isomalt, Sodium Pca, Sodium Lactate, Sodium Benzoate, Caprylyl Glycol, 1,2-Hexanediol, Peppermint Oil, Tocopherol, Squalane, Glutathione, Grapefruit Peel Oil, Citrus Aurantium Dulcis Peel Oil, Phytosterols, Tropolone, Epigallocatechin Gallate, Camellia Oleifera Leaf Extract, Aminomethyl Propanol, Tocotrienols, Squalene, Rice Bran Wax, Aloe Barbadensis Leaf Juice, Urea, Niacinamide, Glycine, Fructose, Vitis Vinifera Fruit Cell Extract Grape Fruit Cell Extract, Lecithin, Inositol, Rh-Oligopeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/pca-skin/rejuvenating-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/pca-skin/rejuvenating-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/pca-skin/rejuvenating-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/pca-skin/rejuvenating-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/pca-skin/rejuvenating-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/pca-skin/rejuvenating-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/pca-skin/rejuvenating-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/pca-skin/rejuvenating-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/pca-skin/rejuvenating-serum/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/pca-skin/rejuvenating-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/pca-skin/rejuvenating-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/pca-skin/rejuvenating-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/pca-skin/rejuvenating-serum/for/combination-skin