# Paula's Choice RESIST Super Antioxidant Concentrate Serum for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Paula's Choice](https://lovi.care/skincare/ca/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry skin.

## Why this fit

- Excellent suitability for your dry skin is provided by ingredients like Glycerin and Ceramide NP, which offer humectant and emollient actions to support your skin barrier and hydration, while Tetrahexyldecyl Ascorbate and Ferulic Acid deliver potent antioxidant protection and brighten your complexion.
- The inclusion of Tocopherol and Beta-Glucan further soothes and nourishes your dry or flaky skin, enhancing overall comfort and resilience.
- This formula is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of beneficial compounds.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Tetrahexyldecyl Ascorbate, Ceramide Np, Palmitoyl Tripeptide-5, Superoxide Dismutase

## What the research says

- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))

## What reviewers say

Based on limited data, users with dry, mature, or sensitive skin frequently praise this serum for its rich, hydrating texture that functions as a barrier against environmental stress, often noting a visible "glow" and improved plumpness. Users with combination or oily skin often find the silicone-heavy formula too occlusive, leading to a greasy finish or potential congestion.

- Liked: Deeply hydrating (often mentioned)
- Disliked: Greasy/shiny finish (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Soothes sensitive skin (sometimes noted)
- Disliked: Heavy silicone feel (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Liked: Protective packaging (rarely noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes RESIST Super Antioxidant Concentrate Serum one of the best fits for dry skin?

This serum is one of the best fits because Glycerin and Ceramide NP draw in moisture and protect your skin barrier, while Tetrahexyldecyl Ascorbate and Ferulic Acid brighten your complexion and shield it from damage. Tocopherol and Beta-Glucan further soothe dry and flaky areas, helping to keep your skin soft, comfortable, and resilient.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for dry skin because ingredients like Glycerin and Ceramide NP help hold in moisture and support your skin barrier. It also includes Tetrahexyldecyl Ascorbate, Ferulic Acid, Tocopherol, and Beta-Glucan to protect, soothe, and nourish flaky skin while keeping irritation away.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### What does Vitamin C do for dry skin?

Vitamin C helps dry skin by boosting moisture and keeping the surface smooth and soft. It may also improve skin hydration and support the outer protective barrier over time.
Sources: [Skin Research and Technology, 2008](https://pubmed.ncbi.nlm.nih.gov/19159387/), [Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in your evening routine after cleansing and before moisturizing, though some serums can also be used in the morning or twice a day. Applying an antioxidant serum as part of a consistent regimen helps brighten your complexion while supporting your dry skin.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to nourish your dry skin and following it with retinol once it absorbs. This approach helps protect your skin barrier while minimizing the likelihood of dryness or irritation.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### How often should I use this serum?

Use this treatment in the evening as part of your routine. It is very safe for dry skin and is unlikely to cause irritation.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts on dry skin, as its formula avoids harsh ingredients and is well-suited for your skin type. However, some reviewers do mention a heavy silicone feel and a greasy or shiny finish, which may feel too rich if you are prone to clogged pores.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ca/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — CA$40.00 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — CA$22.49 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — CA$20.19 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/ca/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — CA$27.99 at Amazon
- Moisturizer: [Tata Harper Repairative Moisturizer](https://lovi.care/skincare/ca/p/tata-harper/repairative-moisturizer/for/dry-skin) — Superior fit — CA$162.00 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide Np, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophyll, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva-Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root Extract, Palm Oil, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin (this page)
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin