# Paula's Choice RESIST Super Antioxidant Concentrate Serum for dry sensitive skin

**Lovi Fit: Superior fit for dry sensitive skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Paula's Choice](https://lovi.care/skincare/ca/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry sensitive skin.

## Why this fit

- Excellent suitability for your dry and sensitive skin is provided by emollients like dimethicone and ceramides, alongside humectants such as glycerin, which offer optimal barrier repair and hydration. Tetrahexyldecyl ascorbate and ferulic acid further enhance this by providing excellent antioxidant protection and evening your skin tone, shielding you from environmental stressors.
- Palmitoyl tripeptide-5 and tocopherol are included to support your skin barrier function and hydration, addressing your dry or flaky skin concerns.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Beta-Glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin): Superior (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Tetrahexyldecyl Ascorbate, Ceramide Np, Palmitoyl Tripeptide-5, Superoxide Dismutase

## What the research says

- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))

## What reviewers say

Based on limited data, users with dry, mature, or sensitive skin frequently praise this serum for its rich, hydrating texture that functions as a barrier against environmental stress, often noting a visible "glow" and improved plumpness. Users with combination or oily skin often find the silicone-heavy formula too occlusive, leading to a greasy finish or potential congestion.

- Liked: Deeply hydrating (often mentioned)
- Disliked: Greasy/shiny finish (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Soothes sensitive skin (sometimes noted)
- Disliked: Heavy silicone feel (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Liked: Protective packaging (rarely noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice Super Antioxidant Concentrate Serum one of the best fits for dry sensitive skin?

This serum is one of the best fits for your dry sensitive skin because it uses dimethicone, ceramides, and glycerin to repair your skin barrier and keep it hydrated. It also features vitamin C and ferulic acid to protect you from environmental stressors, while beta-glucan soothes your skin without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this serum a good fit for dry sensitive skin?

This serum is an exceptional fit for dry sensitive skin because it uses dimethicone, ceramides, and glycerin to repair your moisture barrier and deeply hydrate dry areas. It also includes vitamin C and ferulic acid to shield your skin from environmental damage, while beta-glucan soothes and calms without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Vitamin C do for dry sensitive skin?

Vitamin C helps brighten and smooth dry sensitive skin while reducing wrinkles and improving elasticity. It is generally well tolerated and unlikely to cause irritation when properly formulated, leaving the skin looking more radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38397772/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep your skin safe from sun exposure while delivering antioxidants and barrier-repairing ingredients.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help calm and protect your dry, sensitive skin before layering your retinol. Because this product is very gentle, it is unlikely to cause irritation when combined with active treatments.

### How often should I use this serum?

This treatment is used in the evening once a day, following your toner and before your moisturizer. It is unlikely to cause irritation on dry and sensitive skin because it avoids harsh ingredients and includes soothing components.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to cause breakouts for dry sensitive skin because it avoids harsh ingredients and includes soothing components like beta-glucan, though a few reviewers have noted a greasy or heavy feel.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ca/p/kravebeauty/great-barrier-relief/for/dry-sensitive-skin) — High fit — CA$40.00 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/dry-sensitive-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/dry-sensitive-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — CA$20.19 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/ca/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — CA$38.00 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide Np, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophyll, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva-Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root Extract, Palm Oil, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin
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- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin
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