# Paula's Choice RESIST Super Antioxidant Concentrate Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Paula's Choice](https://lovi.care/skincare/ca/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your combination skin and acne concerns is provided by Magnesium Ascorbyl Phosphate and Thioctic Acid, which target inflammation and promote skin repair. Tetrahexyldecyl Ascorbate and Ferulic Acid offer superb antioxidant protection and skin tone evening, maximizing benefits for your skin health.
- Beta-Glucan and Glycerin further support skin repair and hydration, contributing to overall skin comfort and resilience.
- The formulation is safe for your acne-prone skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Tetrahexyldecyl Ascorbate, Ceramide Np, Palmitoyl Tripeptide-5, Superoxide Dismutase

## What the research says

- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))

## What reviewers say

Based on limited data, users with dry, mature, or sensitive skin frequently praise this serum for its rich, hydrating texture that functions as a barrier against environmental stress, often noting a visible "glow" and improved plumpness. Users with combination or oily skin often find the silicone-heavy formula too occlusive, leading to a greasy finish or potential congestion.

- Liked: Deeply hydrating (often mentioned)
- Disliked: Greasy/shiny finish (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Soothes sensitive skin (sometimes noted)
- Disliked: Heavy silicone feel (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Liked: Protective packaging (rarely noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes the RESIST Super Antioxidant Concentrate Serum a great fit for acne-prone skin?

This serum is a great fit because ingredients like Magnesium Ascorbyl Phosphate and Thioctic Acid help calm redness and support skin repair. It is also safe for acne-prone skin, with soothing components that mean it is unlikely to cause irritation.

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because Magnesium Ascorbyl Phosphate and Thioctic Acid calm redness and help repair skin. Tetrahexyldecyl Ascorbate and Ferulic Acid provide strong antioxidant protection, while Beta-Glucan and Glycerin keep your face hydrated and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Vitamin C do for acne-prone skin?

Vitamin C helps brighten skin, smooth out uneven tones, and fade dark spots left behind by breakouts. It is also packed with antioxidants that may help protect acne-prone skin from everyday environmental stress.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/), [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39231081/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing, for simplicity and extra safety around sun exposure. It is unlikely to cause irritation on acne-prone skin.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first to calm your skin and provide antioxidant protection. This routine is generally safe and helps keep your skin comfortable, but you may want to introduce them gradually to avoid any irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### How often should I use this serum?

You can use this serum in your evening routine, applying it after your cleansing toner and before your moisturizer. It is unlikely to cause irritation on acne-prone skin, so you can use it daily if your skin tolerates it well.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for your acne-prone skin because it targets inflammation and helps repair skin safely without harsh ingredients. Reviewers rarely report breakouts, and it includes soothing components that keep irritation unlikely.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/acne-prone-skin) — High fit — CA$27.99 at Amazon
- [ANUA PEACH 70% NIACINAMIDE SERUM](https://lovi.care/skincare/ca/p/anua/peach-70-niacinamide-serum/for/acne-prone-skin) — High fit — CA$33.50 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- Moisturizer: [CeraVe CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide Np, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophyll, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva-Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root Extract, Palm Oil, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin