# Paula's Choice PRO Retinaldehyde Dual-Retinoid Treatment for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Paula's Choice](https://lovi.care/skincare/ca/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Offers moderate anti-aging benefits for your normal skin with sensitivity, as retinaldehyde and retinol work to minimize fine lines and wrinkles while niacinamide and bisabolol provide mild anti-inflammatory effects to support redness and irritation.
- The formula includes hydrating and soothing ingredients like hyaluronic acid and chamomile extract, which are beneficial for overall skin health.
- The product is safe for your skin due to the absence of harsh ingredients and the inclusion of numerous calming agents.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Retinaldehyde, Retinol, Niacinamide, Hyaluronic Acid, Squalane

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities. ([Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users with acne-prone and aging skin report significant improvements in skin clarity and texture, often describing the product as a "game changer" for stubborn breakouts and fine lines. While the dual-retinoid formula is praised for being surprisingly gentle and effective where other retinols failed, some users experienced an initial purging phase and noted the bright yellow formula can stain fabrics.

- Liked: Clears acne (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Smoothes texture (often mentioned)
- Liked: Pleasant texture (sometimes noted)
- Disliked: Initial purging phase (sometimes noted)
- Disliked: Stains fabric yellow (sometimes noted)
- Disliked: High price point (rarely noted)
- Disliked: Slow to show results (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice PRO Retinaldehyde Dual-Retinoid Treatment a great fit for sensitive skin?

This treatment is a great fit because it contains retinaldehyde and retinol to smooth fine lines while using soothing ingredients like niacinamide, bisabolol, and chamomile extract to calm redness and irritation. It has a very safe profile for sensitive skin due to the absence of harsh ingredients and the inclusion of many calming agents.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this treatment a good fit for sensitive skin?

This treatment is a great fit for sensitive skin because it contains niacinamide and bisabolol to help calm redness and irritation. It also includes soothing chamomile extract and hyaluronic acid to keep your skin hydrated and comfortable.

### What does Retinal do for sensitive skin?

Retinal helps smooth fine lines, improve texture, and even out skin tone while generally maintaining a good tolerance profile with a lower likelihood of irritation compared to stronger forms of vitamin A.
Sources: [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39496127/), [Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473963/)

### What does Retinol do for sensitive skin?

Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your cleanser and soothing toner, followed by a moisturizer. It helps smooth fine lines while keeping your skin calm and comfortable.

### Can I use this treatment with vitamin C, and in what order?

It is generally best to use this treatment in your evening routine and vitamin C in the morning to help avoid extra stinging or irritation on sensitive skin. If you do use them in the same routine, apply your vitamin C first, let it absorb, and then follow with this treatment.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### How often should I use this treatment?

This treatment is a great fit for your sensitive skin and works best when applied in your evening routine. You can start using it once a week, and if your skin tolerates it well and stays calm and smooth, you may carefully use it more often.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Can this treatment clog pores, cause breakouts or purging for sensitive skin?

Yes, this treatment may cause an initial purging phase as your skin adjusts to the retinoids, but it is unlikely to clog pores since it avoids heavy, pore-clogging ingredients. Reviewers moderately complain about breakouts during the first weeks of use, which is a normal reaction when starting potent anti-aging formulas.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — CA$33.98 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — CA$24.44 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/sensitive-skin) — High fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Sephora: CA$77.60 (https://www.sephora.com/ca/en/product/clinical-pro-retinaldehyde-treatment-for-clear-luminous-skin-P515039?skuId=2834760)
Prices checked 16 Oct 2026.

## Ingredients

Water, Glycerin, Cetearyl Alcohol, Retinaldehyde, Retinol, Caprylic Capric Triglyceride, Squalane, Butyrospermum Parkii Butter Shea Butter, Niacinamide, Tocopherol Vitamin E, Panthenol, Hyaluronic Acid, Allantoin, Bisabolol, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Aloe Barbadensis Leaf Juice, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin