# Paula's Choice 25% Vitamin C + Glutathione Clinical Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Paula's Choice](https://lovi.care/skincare/ca/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate brightening and evening of skin tone for your oily skin, as tetrahexyldecyl ascorbate and glutathione provide antioxidant and brightening effects that are generally beneficial but not directly targeted at your acne, blemishes, and breakouts.
- The presence of ascorbyl glucoside and Pyrus Malus Fruit Extract offers some antioxidant and potential seboregulating benefits, which are supportive for oily skin.
- The product is safe for your oily skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Ascorbic Acid, Glutathione, Ergothioneine, Ascorbyl Glucoside, Tocopherol

## What the research says

- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Topical formulations containing 1.25% Malus sp. extract or 0.75% rutin protected against UVB-induced sunburn cells, caspase-3 activation, cyclobutane pyrimidine dimers, lipid peroxidation, and metalloproteinase formation in ex vivo skin explants and 3D tissue-engineered skin. ([Rejuvenation Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32242497/))
- Dermocosmetic creams containing 6%, 12%, and 15% of standardized wild apple fruit ultrasonic extract increased skin hydration proportionally to extract concentration after 28 days of application on healthy volunteers without altering transepidermal water loss or skin pH. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35048513/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Ergothioneine at nanomolar concentrations ameliorated UVA-induced skin damage, reactive oxygen species, and apoptosis in human keratinocyte-derived HaCaT cells by upregulating Nrf2/ARE-mediated antioxidant genes. ([Free Radical Biology & Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26021820/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Many reviewers report a noticeable glow, improved skin bounce, and the fading of stubborn sun spots and post-inflammatory hyperpigmentation after consistent use.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Effective brightening (often mentioned)
- Liked: Elegant texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Heavy for oily (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Paula's Choice 25% Vitamin C + Glutathione Clinical Serum work for oily acne-prone skin?

This serum offers moderate brightening for your oily skin, though it is not directly targeted at your acne and breakouts. An acne-prone skin type needs ingredients like niacinamide and propolis to balance oil and target breakouts without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Tetrahexyldecyl ascorbate, glutathione, and ascorbyl glucoside make this serum a fit by providing antioxidant and brightening effects, while apple fruit extract offers supportive oil-balancing benefits. For this skin type, a treatment needs ingredients like niacinamide and propolis to directly target acne and blemishes while controlling excess oil.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Vitamin C do for oily acne-prone skin?

Vitamin C helps brighten skin, smooth out texture, and improve uneven spots for oily acne-prone skin. It may also help fade marks left behind by blemishes.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Glutathione do for oily acne-prone skin?

Glutathione helps protect oily, acne-prone skin from daily stress and irritation by acting as an antioxidant that supports a healthy skin barrier. It is unlikely to clog pores, but this skin type also needs ingredients that clear out oil and soothe redness to stay calm and smooth.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/), [Current Problems in Dermatology, 2001](https://pubmed.ncbi.nlm.nih.gov/11225199/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

Apply this serum in your evening routine, using it after cleansing and toning and before applying your moisturizer. To best care for oily acne-prone skin, a product of this type needs additional ingredients that directly target breakouts and blemishes alongside brightening benefits.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the retinol first and following with this treatment, or by using one in the morning and the other at night. Because this product does not contain harsh ingredients, it is unlikely to irritate your skin, though an oily acne-prone skin often needs treatments that directly target breakouts and blemishes with ingredients like salicylic acid or benzoyl peroxide.

### How often should I use this serum?

This treatment is used in the evening, applying it once a day for simplicity and extra safety around sun exposure. It is safe for your skin with no risks of irritation due to the absence of harsh ingredients. Oily acne-prone skin needs this type of product to include antioxidants and brightening ingredients that help even skin tone, along with oil-balancing ingredients.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on oily acne-prone skin because it lacks harsh ingredients, though a few reviewers have reported occasional blemishes. An average fit for your skin like this one needs targeted blemish-fighting ingredients and oil-balancing agents to properly clear breakouts while brightening.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$99.00 (https://www.amazon.ca/dp/B0HCTBJSSJ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Sephora: CA$99.00 (https://www.sephora.com/ca/en/product/paulas-choice-25-vitamin-c-glutathione-clinical-serum-P510467?skuId=2744464)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Rice Bran Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco Caprylate Caprate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract Sunflower Seed Extract, Urea, Mannitol, Caprylic Capric Triglyceride, Sodium Pca, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Sodium Hyaluronate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin (this page)
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