# Olay Regenerist Regenerating Serum for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Olay](https://lovi.care/skincare/ca/brands/olay)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your oily skin due to niacinamide's seboregulation and humectant properties, complemented by glycerin for hydration, though its primary benefits are supportive rather than directly targeting acne and blemishes.
- The presence of palmitoyl pentapeptide-4 and niacinamide aids in smoothing texture and minimizing fine lines, providing general skincare advantages.
- The formula is safe for your oily skin, with no risks of irritation from harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Niacinamide, Palmitoyl Pentapeptide-4, Glycerin, Tocopheryl Acetate, Allantoin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Based on a very large amount of data, users love this serum's lightweight, silky texture that absorbs quickly, making it ideal for layering. Many report softer, hydrated skin and a reduction in fine lines, contributing to a smoother appearance. A small number of users experienced breakouts or found the texture sticky.

- Liked: Effective hydration (mostly mentioned)
- Liked: Silky texture (mostly mentioned)
- Liked: Convenient packaging (sometimes noted)
- Liked: Fragrance-free option (sometimes noted)
- Liked: Visible results (sometimes noted)
- Disliked: Ingredient concerns (rarely noted)
- Disliked: Packaging flaws (rarely noted)
- Disliked: Skin reactions (rarely noted)
- Disliked: Texture issues (rarely noted)
- Disliked: Value for money (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Olay Regenerist Regenerating Serum a great fit for oily acne-prone skin?

Olay Regenerist Regenerating Serum is a great fit for your oily acne-prone skin because niacinamide helps balance oil, while glycerin provides lightweight hydration without clogging pores. The formula also smooths texture with peptides and is very safe, as it avoids harsh ingredients that might cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because niacinamide helps balance oil while glycerin delivers hydration without heaviness. Palmitoyl pentapeptide-4 and niacinamide also smooth your texture and soften fine lines, and the formula is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does Palmitoyl Pentapeptide-4 do for oily acne-prone skin?

Palmitoyl Pentapeptide-4 helps smooth fine lines and improves the look of aging skin, but it is not specifically formulated to treat acne. For oily, acne-prone skin, a product of this type needs added ingredients that clear pores and calm redness.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting it in the evening keeps things simple and helps protect your skin from the sun.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin hydrated while it adjusts to the retinol. This formula is safe for oily skin and is unlikely to cause irritation.

### How often should I use this serum?

You can use this treatment in your evening routine, as treatments with active ingredients are typically placed at night for simplicity and extra safety around sun exposure. Some serums can also be used in the morning or twice a day if your skin tolerates them well.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for your oily acne-prone skin because it has a safe formula with a low risk of skin reactions. It also contains ingredients like tocopheryl acetate that help keep skin clear and balanced.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Dimethicone, Glycerin, Niacinamide, Dimethicone Crosspolymer, Polymethylsilsesquioxane, Panthenol, Polyethylene, Palmitoyl Pentapeptide-4, Sodium Peg-7 Olive Carboxylate Oil, Tocopheryl Acetate, Allantoin, Camellia Sinensis Leaf Extract, Dimethiconol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dmdm Hydantoin, Iodopropynyl Butylcarbamate, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, C13-14 Isoparaffin, Aminomethyl Propanol, Laureth-4, Laureth-7, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/olay/regenerist-regenerating-serum/for/oily-acne-prone-skin