# Numbuzin No.2 Protein 43% Creamy Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Numbuzin](https://lovi.care/skincare/ca/brands/numbuzin)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- This serum offers moderate benefits for your normal skin, as hydrolyzed proteins and ceramides np support barrier repair and emollient action, but it lacks specialized ingredients to target your redness and irritation.
- While oat extract protein and rice seed protein provide excellent hydration and improve skin elasticity, they do not directly address inflammation.
- The product is safe for your sensitive skin due to the absence of harsh ingredients and the inclusion of soothing oat and rice seed proteins.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Content Protein, Rice Seed Protein, Hydrolyzed Protein, Ceramide Np, Cholesterol

## What the research says

- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion. ([International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/))
- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Combined treatment with human umbilical cord mesenchymal stem cell-derived exosomes and hydrolyzed collagen oligopeptides enhanced proliferation and migration, reduced reactive oxygen species and senescence-associated beta-galactosidase activity, increased type I and type III collagen expression, and decreased metalloproteinases, inflammatory cytokines, and senescence markers in human skin fibroblasts compared to either treatment alone. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/))
- Collagen peptides induced cell proliferation and pro-collagen-1α expression, increased TGF-β and VEGF, and suppressed the LPS-induced inflammatory response in human skin fibroblasts and keratinocytes. ([Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/))
- Botulinum toxin-A encapsulated in phosphatidylcholine/cholesterol nanoliposomes delivered transdermally achieved a diffusion depth of 380 μm and showed a nonsignificant advantage in relieving post-acne scarring compared to hyaluronic acid hydrogel treatment in 12 facial patients. ([Journal of Materials Science. Materials in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39073502/))
- Topical application of cholesterol sulfate increases stratum corneum thickness and inhibits protease-induced cell dissociation by competitively inhibiting serine proteases in mice and human stratum corneum. ([The Journal of Investigative Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9699715/))
- Topical lovastatin treatment impairs the recovery of cutaneous permeability barrier function and stratum corneum cholesterol levels after acetone disruption in mice, an effect normalized by simultaneous treatment with mevalonate or cholesterol. ([The Journal of Clinical Investigation, 1990](https://pubmed.ncbi.nlm.nih.gov/2243142/))

## Why other moisturizers fit sensitive skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A topical microemulsion containing Punica granatum extract significantly reduced skin erythema and melanin compared to a placebo in healthy Asian subjects over 12 weeks. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25610348/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))

## What reviewers say

This serum is widely praised as a "winter savior" for dry, sensitive, and dehydrated skin, effectively repairing damaged barriers and alleviating flakiness. Users consistently report a plump, healthy glow and deep "inner" hydration, though its rich, protein-heavy formula can be too heavy or potentially pore-clogging for oily or acne-prone skin types.

- Liked: Deep barrier repair (mostly mentioned)
- Liked: Long-lasting hydration (often mentioned)
- Liked: Rich creamy texture (often mentioned)
- Liked: Glowy finish (sometimes noted)
- Disliked: Not for oily skin (sometimes noted)
- Disliked: Potential breakouts (sometimes noted)
- Disliked: Stickiness/tackiness (sometimes noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Numbuzin No.2 Protein 43% Creamy Serum work for sensitive skin?

This serum works moderately well for sensitive skin because its proteins and ceramides help repair the skin barrier, but it lacks specialized ingredients to calm redness and irritation. A product of this type needs effective hydrating and soothing ingredients that address redness and irritation without posing any risk of irritation, along with multiple types of hyaluronic acid, green tea extracts, and peptides.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum fits your sensitive skin thanks to oat extract protein and rice seed protein, which provide gentle hydration and help keep your skin comfortable. Ceramide NP and cholesterol also support your skin barrier without causing irritation. However, a product for this skin needs extra soothing and calming ingredients to target redness and irritation.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### What does Content Protein do for sensitive skin?

Content Protein helps calm sensitive skin by supporting barrier recovery and keeping moisture locked in. However, protein ingredients like oat derivatives may occasionally trigger reactions in very reactive or compromised skin types.
Sources: [Bioengineering, 2025](https://pubmed.ncbi.nlm.nih.gov/41301205/), [Food & Function, 2017](https://pubmed.ncbi.nlm.nih.gov/28174772/)

### What does Rice Seed Protein do for sensitive skin?

Rice Seed Protein helps calm sensitive skin and keeps it feeling soft and smooth. Rice-derived ingredients are known to soothe irritation and support the skin barrier, making them a gentle choice for easily upset skin.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35587098/), [International Journal of Nanomedicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40225220/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine, applied after your toner and before your moisturizer. Treatments with actives are placed in the evening for simplicity and extra safety around sun exposure, though some can also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help keep your skin comfortable and hydrated. This type of product works well when it includes barrier-restoring ingredients like ceramides and soothing proteins to support sensitive skin during strong treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### How often should I use this serum?

This serum fits your sensitive skin reasonably well and is safe to use in your evening routine, though other products may fit it better. To care for sensitive skin properly, a product of this type needs specialized soothing ingredients that directly target redness and irritation.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum may cause breakouts for some users with sensitive skin since reviewers moderately complain about potential blemishes. To prevent breakouts, sensitive skin needs lightweight, non-clogging hydrators and soothing ingredients that calm irritation without heavy oils.

### Can I use this serum around the eyes or on my body?

This serum is safe to use around the eyes and on the body because it lacks harsh ingredients and includes soothing proteins, though sensitive skin requires targeted calming ingredients to effectively manage redness and irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/ca/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/sensitive-skin) — High fit — CA$40.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Amazon.ca: CA$28.99 (https://www.amazon.ca/dp/B0F5WDZKW3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Voat Extract Protein, Water, Cyclopentasiloxane, Butylene Glycol, Cetearyl Ethyl Hexanoate, Cyclohexasiloxane, Phenyl Trimethicone, Cetyl Pg, Sebum-10 1 Dimethicone, Hydrogenate Tid Poly, Rice Seed Protein, Prunus Amygdalus Dulcis Protein, Hydrolyzed Corn Protein, Hydrolyzed Protein, Hydrolyzed Pea Protein, Hydrolyzed Milk Protein, Glycine Soja Protein Soybean Protein, Hydrolyzed Lupine Protein, Ceramide Np, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin