numbuzin 5 Glutathione Vitamin Concentrated Serum for dry sensitive skin
Glutathione
Niacinamide
3-O-Ethyl Ascorbic Acid
Tranexamic Acid
Alpha-ArbutinHigh
- HighDry Skin Fit
- HighEffectiveness
- HighSafety
One of the best serums for dry sensitive skin.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This serum offers excellent brightening and evening of skin tone due to the presence of niacinamide and glutathione, which promote a more luminous complexion for your dry and sensitive skin.
- It also provides relevant benefits for dry or flaky skin and sensitivity due to the presence of Panthenol and Sodium Hyaluronate, which offer hydration and soothing.
- The product is safe for your dry and sensitive skin as it lacks prohibited or harsh ingredients, minimizing irritation risks.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.7Overall rating based on 2.0k+ reviewsBased on a very large amount of data, users with dullness, hyperpigmentation, and sensitive skin frequently praise this serum for its ability to fade acne scars and even out skin tone without causing irritation. The majority report a "glass skin" glow and rapid absorption, while a small minority experienced breakouts or found the brightening effects too slow to appear.
Highlights
Fades dark spots Mostly Mentioned
- “Acne marks faded noticeably”
- “Helps with pigmentation issues”
- “Sunspots have faded”
- “Clear up hyperpigmentation”
- “Reduces appearance of spots”
Gentle on skin Often Mentioned
- “No irritation”
- “Great for sensitive skin”
- “Gentle yet effective”
- “No stinging”
- “Soothing ingredients”
Lightweight texture Often Mentioned
- “Absorbs instantly”
- “Non-sticky formula”
- “Lightweight milky texture”
- “Sinks in quickly”
- “Does not feel heavy”
Hydrating glow Sometimes Noted
- “Natural glass-skin glow”
- “Leaves skin soft”
- “Very hydrating”
- “Restores natural glow”
- “Dewy finish”
Caused breakouts Rarely Noted
- “Caused tiny bumps”
- “More acne on my skin”
- “Triggered whiteheads”
- “Broke me out”
- “Clogged my pores”
Packaging issues Rarely Noted
- “Dropper is messy”
- “Hard to get last drops”
- “Bottle leaks slightly”
Slow results Rarely Noted
- “Did nothing to brighten”
- “No big improvement”
- “Takes a long time”
- “Saw no difference”
- “Overhyped results”
Tacky finish Rarely Noted
- “Left a slightly tacky feeling”
- “Sticky residue”
- “Felt heavy initially”
- “Greasy after application”
Sources: lovi.care, oliveyoung.com, iherb.com, stylevana.com, yesstyle.com, reddit.com, and more
Questions and answers
What makes numbuzin 5 Serum a great fit for dry sensitive skin?
This serum is a great fit because it brightens uneven skin tone with niacinamide and glutathione while keeping dry, sensitive skin calm and hydrated using panthenol and sodium hyaluronate. It is also formulated without harsh ingredients, which helps minimize irritation risks.
The British Journal of Dermatology, 2002Clinical, Cosmetic and Investigational Dermatology, 2014
Which ingredients make this serum a good fit for dry sensitive skin?
This serum is a great fit because panthenol and sodium hyaluronate help hydrate and calm dry, sensitive skin, while niacinamide and glutathione brighten and even your skin tone. It is also very safe for your skin type and is unlikely to cause irritation.
The British Journal of Dermatology, 2002Clinical, Cosmetic and Investigational Dermatology, 2014
What does Glutathione do for dry sensitive skin?
Glutathione helps improve moisture content and smoothness while reducing oxidative stress, making it a helpful option for dry sensitive skin. This ingredient may enhance hydration and elasticity while maintaining a gentle profile. To properly care for dry sensitive skin, a product of this type needs soothing and hydrating ingredients that support the skin barrier.
Clinical, Cosmetic and Investigational Dermatology, 2014Journal of the European Academy of Dermatology and Venereology, 2024
What does Niacinamide do for dry sensitive skin?
Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Journal of Cosmetic Dermatology, 2004International Journal of Pharmaceutics, 2013
Where does this serum go in a skincare routine for dry sensitive skin?
This treatment serum goes in the evening routine after your toner and before your moisturizer. It is a great fit for your dry and sensitive skin because it helps brighten your complexion while providing soothing hydration without causing irritation.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to give your dry and sensitive skin hydration and brightening, followed by your retinol. This product is unlikely to cause irritation because it lacks harsh ingredients and includes soothing panthenol.
Journal of Cosmetic Dermatology, 2024The British Journal of Dermatology, 2002
How often should I use this serum?
This serum is used in the evening, applying it as part of your nighttime routine. It is a great fit for your dry and sensitive skin because it brings brightening and soothing benefits while keeping irritation risks low.
The British Journal of Dermatology, 2002Clinical, Cosmetic and Investigational Dermatology, 2014
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
This serum is unlikely to clog pores or cause breakouts for your dry sensitive skin. Reviewers rarely mention breakouts, and the formula lacks harsh ingredients that typically trigger irritation.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Behenyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation.
American Journal of Surgery, 2005Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.
Journal of Cosmetic Science, 2020Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.
Heliyon, 2023Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.
Journal of Cosmetic Dermatology, 2025
Ingredients
Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic Capric Triglyceride, Sorbitol, Bifida Ferment Filtrate, Chondrus Crispus Extract, Butyrospermum Parkii Butter, Saccharum Officinarum Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Tremella Fuciformis Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Alpha Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide Np, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, L Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Alpha Lipoic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium Edta
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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