# numbuz:n Pantothenic B5 Active Soothing Serum for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [numbuz:n](https://lovi.care/skincare/ca/brands/numbuz-n)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin with sensitivity, as Panthenol Vitamin B5 and Centella Asiatica Extract provide anti-inflammatory action and barrier repair to address redness and irritation.
- The inclusion of Hyaluronic Acid and Glycerin ensures excellent moisturizing and barrier resilience, further supporting your skin's needs.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Pantothenic Acid Vitamin B5, Hyaluronic Acid, Centella Asiatica Extract, Allantoin, Niacinamide

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol following PicoWay laser treatment decreased transepidermal water loss, increased hydration and skin elasticity, reduced wrinkles and redness, and improved skin tone in 88 Chinese females compared to a standard care control group. ([Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Treatment with an asiaticoside-containing cream applied twice daily for 12 weeks significantly improved periorbital wrinkles in 65% of 27 female volunteers compared to a vehicle control cream. ([International Journal of Cosmetic Science, 2008](https://pubmed.ncbi.nlm.nih.gov/18452433/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## What reviewers say

This serum is widely praised by users with oily, acne-prone, and dehydrated skin for its ability to deeply hydrate without clogging pores or leaving a greasy residue. While many report significant improvements in redness and oil control, results vary for those with dry skin or specific sensitivities, with some users finding it insufficiently moisturizing on its own.

- Liked: Lightweight & fast (mostly mentioned)
- Liked: Hydrating for oily (often mentioned)
- Liked: Soothing redness (often mentioned)
- Liked: Oil control (sometimes noted)
- Disliked: Not enough moisture (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: No visible results (rarely noted)
- Disliked: Price per volume (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes numbuz:n Pantothenic B5 Active Soothing Serum a great fit for sensitive skin?

numbuz:n Pantothenic B5 Active Soothing Serum is a great fit for sensitive skin because Panthenol Vitamin B5 and Centella Asiatica Extract help calm redness and repair the skin barrier. Hyaluronic Acid and Glycerin add deep moisture, and the serum is very unlikely to cause irritation since it leaves out harsh ingredients.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for sensitive skin?

Pantothenic Acid Vitamin B5 and Centella Asiatica Extract make this serum a great fit by calming redness and repairing the skin barrier. Hyaluronic Acid and Glycerin also help by keeping your skin deeply moisturized and comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Pantothenic Acid do for sensitive skin?

Pantothenic acid helps soothe sensitive skin and keeps it feeling soft by improving moisture and supporting skin barrier repair, but frequent exposure may occasionally cause skin irritation or hypersensitivity in some people.
Sources: [Pharmaceutics, 2026](https://pubmed.ncbi.nlm.nih.gov/42514853/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in your evening routine as a treatment step after toning and before moisturizing, which keeps things simple and safe for your skin. Using soothing ingredients like Panthenol Vitamin B5 and Centella Asiatica Extract helps calm redness and irritation while supporting your skin barrier.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol, applying the serum first to help calm and hydrate your skin before retinol. This approach helps reduce potential irritation while supporting your skin barrier, as panthenol and centella asiatica extract provide soothing and repairing benefits.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. Daily application helps keep your sensitive skin calm and well-hydrated.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to cause breakouts or clog pores on sensitive skin because it is free of harsh ingredients and packed with soothing components. It features calming Centella Asiatica Extract and Pantothenic Acid Vitamin B5 to help keep skin clear and calm.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum around the eyes and on your body because its gentle moisturizing treatment ingredients keep thin skin well-hydrated and calm. The safe formula is unlikely to cause irritation, making it suitable for delicate areas prone to dryness and redness.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/sensitive-skin) — High fit — CA$21.81 at Amazon
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ca/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/sensitive-skin) — High fit — CA$25.99 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/sensitive-skin) — Average fit — CA$37.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Amazon.ca: CA$23.20 (https://www.amazon.ca/dp/B0D176VZP2?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Panthenol Vitamin B5, Glycerin, Butylene Glycol, Hyaluronic Acid, Allantoin, Centella Asiatica Extract, Madecassoside, Asiaticoside, Asiatic Acid, Madecassic Acid, Beta-Glucan, Sodium Pca, Tocopherol Vitamin E, Caprylyl Glycol, Ethylhexylglycerin, 1,2-Hexanediol, Carbomer, Arginine, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuz-n/pantothenic-b5-active-soothing-serum/for/sensitive-skin