# Neora Advanced SIG-1273 Concentrated Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Neora](https://lovi.care/skincare/ca/brands/neora)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate skin hydration for your oily skin due to glycerin and sodium hyaluronate, which provide humectant action. Citric acid offers mild keratolytic benefits, but these are not directly targeted at your primary concerns of acne, blemishes, and breakouts.
- While the product is safe for oily skin and free from harsh ingredients, its functional benefits are primarily supportive rather than directly addressing your main goal of managing acne and breakouts.
- The safety profile is excellent, with no identified risks of irritation for your oily skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Sodium Hyaluronate, Glycerin, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentylene Glycol, Citric Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone. ([Dermatologic Surgery, 1997](https://pubmed.ncbi.nlm.nih.gov/9256916/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on limited data, users describe the serum as a lightweight, hydrating formula that leaves skin feeling smooth and looking radiant. While many report improvements in skin texture and a healthy glow, some users feel the anti-aging results are subtle rather than dramatic, especially when weighed against the product's premium price point.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating effect (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Radiant glow (sometimes noted)
- Liked: Smoother skin (sometimes noted)
- Disliked: MLM model (sometimes noted)
- Disliked: Subtle results (sometimes noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Neora Advanced SIG-1273 Concentrated Serum work for oily acne-prone skin?

This serum is an average fit for your oily acne-prone skin, offering moderate hydration and mild exfoliation while lacking ingredients that directly target breakouts. It is very safe and unlikely to cause irritation, but managing acne and excess oil effectively requires a treatment containing ingredients like niacinamide, propolis, or vitamin C.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Glycerin and sodium hyaluronate provide moderate hydration for your oily skin, while citric acid offers mild cleansing of dead skin cells. However, a product for this skin needs ingredients like niacinamide, propolis, or vitamin C to directly help with acne and breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### What does Glycerin do for oily acne-prone skin?

Glycerin helps keep oily acne-prone skin hydrated without feeling heavy. It draws moisture into the skin while supporting the skin barrier so it stays soft and balanced.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine after cleansing and toning, and before your moisturizer. Oily acne-prone skin needs a treatment with targeted blemish-fighting ingredients like salicylic acid or benzoyl peroxide to directly manage breakouts and blemishes.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your oily skin moderate hydration, followed by your retinol. The product is unlikely to irritate your skin, though an acne treatment containing ingredients like topical retinoids or benzoyl peroxide is better suited to directly target breakouts.
Sources: [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

This serum is safe to use every evening as part of your routine for oily acne-prone skin, as it is unlikely to cause irritation. Because it mainly provides hydration rather than targeting blemishes, an oily skin dealing with breakouts needs an acne-focused treatment with ingredients like salicylic acid or benzoyl peroxide to clear pores and reduce pimples.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on oily acne-prone skin because it has a very safe formula free from heavy ingredients. However, it only provides basic hydration and lacks targeted blemish-fighting ingredients, so an oily acne-prone skin needs products with specialized acne-clearing acids or retinoids to properly manage breakouts.

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin
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- Spain: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin
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