# NEOCUTIS Bio Serum Firm for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [NEOCUTIS](https://lovi.care/skincare/ca/brands/neocutis)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers excellent firming and plumping for your normal skin due to the peptides Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate, which support collagen production and skin elasticity to address wrinkles and fine lines.
- Glycerin and Sodium Hyaluronate provide humectant action, enhancing hydration and skin comfort for your normal skin type.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Glycerin and Squalane.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/oily-acne-prone-skin): Average

## Key ingredients

Rejuvenating Growth Factor, Peptides, Sodium Hyaluronate, Acetyl Glucosamine, Aminopropyl Ascorbyl Phosphate

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate. ([Scientific Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/33037252/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## What reviewers say

Users frequently report significant improvements in skin texture and hydration, with many experiencing smoother skin and a reduction in fine lines and increased firmness within the first week. The product is also often praised for its hydrating and plumping effects, leaving skin with a dewy glow and appearing more radiant. While a substantial number of users find the anti-aging results to be worth the cost, the high price point is a commonly mentioned drawback.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating and Plumping (often mentioned)
- Liked: Improves Skin Texture (often mentioned)
- Liked: Reduces Fine Lines (often mentioned)
- Liked: Fast Results (sometimes noted)
- Liked: Gentle on Skin (sometimes noted)
- Disliked: Irritation/Reactions (rarely noted)
- Disliked: Lack of Results (rarely noted)
- Disliked: Product Pilling (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Neocutis Bio Serum Firm a great fit for mature skin?

Neocutis Bio Serum Firm is a great fit for mature skin because it offers excellent firming and plumping through peptides like Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate that support collagen and elasticity to help smooth out fine lines and wrinkles. Glycerin and Sodium Hyaluronate provide moisture to enhance skin comfort, while soothing components like squalane help ensure an excellent safety profile without irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Rejuvenating Growth Factor, peptides like Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate, and Sodium Hyaluronate make this serum a great fit for mature skin. These ingredients help support collagen production, improve skin elasticity, and enhance hydration to smooth out fine lines and wrinkles. The formula also includes Glycerin and Squalane to provide extra comfort without irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Growth Factor do for mature skin?

Growth factor helps improve fine lines, wrinkles, and overall texture for mature skin by supporting skin renewal with a low risk of irritation. It may also boost hydration and make the skin look smoother when used consistently in your routine.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37222303/), [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33282098/)

### What do Peptides do for mature skin?

Peptides help mature skin by signaling skin cells to boost collagen production, which improves firmness and smooths out fine lines. They are generally safe to use daily, though their ability to deliver results depends heavily on how well the formula can sink into the skin.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19570099/), [Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/39858482/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Some serums can also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol to help smooth and firm mature skin while keeping it comfortable. This combination is generally well tolerated, though starting slowly helps avoid any unexpected sensitivity.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. It is a great fit for mature skin, helping to firm and plump while keeping the skin comfortable and smooth.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because its formula avoids heavy, pore-clogging ingredients and has an excellent safety profile. Soothing components like glycerin and squalane help keep skin comfortable without triggering irritation or reactions.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/mature-skin) — High fit — CA$27.99 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/mature-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neocutis/bio-serum-firm/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/neocutis/bio-serum-firm/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/neocutis/bio-serum-firm/for/mature-skin
- France: https://lovi.care/skincare/fr/p/neocutis/bio-serum-firm/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/neocutis/bio-serum-firm/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/neocutis/bio-serum-firm/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/neocutis/bio-serum-firm/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/neocutis/bio-serum-firm/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/neocutis/bio-serum-firm/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neocutis/bio-serum-firm/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neocutis/bio-serum-firm/for/mature-skin