# Murad Retinol Youth Renewal Night Cream for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Murad](https://lovi.care/skincare/ca/brands/murad)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- This formulation offers high suitability for your combination skin, as niacinamide helps regulate sebum and retinol aids in desquamation, which are beneficial for managing acne and breakouts.
- Sodium hyaluronate and glycerin provide essential hydration, supporting your skin's barrier function and overall health.
- The product is safe for your combination skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/oily-acne-prone-skin): High

## Key ingredients

Retinol, Niacinamide, Sodium Hyaluronate, Hydrolyzed Yeast Extract, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical moisturizers improved skin barrier function and surface moisture, while a postbiotic moisturizer with yeast extract uniquely supported microbiome balance and modulated biomarkers of skin barrier, structure, and inflammation in participants and ex vivo explants exposed to environmental aggressors. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/))
- A maintenance therapy with a cosmeceutical formulation containing hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid over 20 weeks significantly improved even skin tone, spot intensity, spot size, and overall hyperpigmentation in 33 healthy subjects with moderate facial dyspigmentation. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25844613/))
- A methanol yeast extract increases proliferation and migration while decreasing entrance into senescence and apoptosis phases in 3T3 fibroblast cells. ([Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/25898765/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, users report this night cream effectively smooths fine lines and improves skin texture without the harsh irritation often associated with retinol. Many praise its hydrating, lightweight formula for creating a plump and radiant complexion, though a subset of users with sensitive skin experienced dryness or breakouts.

- Liked: Gentle and hydrating (mostly mentioned)
- Liked: Luxurious texture (often mentioned)
- Liked: Visible anti-aging (often mentioned)
- Liked: Radiance and glow (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Strong fragrance (sometimes noted)
- Disliked: Adverse reactions (rarely noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Murad Retinol Youth Renewal Night Cream a great fit for acne-prone skin?

This cream is a great fit because niacinamide helps balance oil while retinol clears pores to manage breakouts, making it well-suited for acne-prone skin. At the same time, sodium hyaluronate and glycerin bring in essential hydration to keep the skin barrier healthy and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for acne-prone skin?

Retinol and niacinamide make this cream a great fit for acne-prone skin because they help manage breakouts and regulate oil. Sodium hyaluronate and glycerin also support this by providing essential hydration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Retinol do for acne-prone skin?

Retinol helps acne-prone skin by speeding up cell turnover and clearing pores to reduce breakouts. It regulates skin growth and fights inflammation, though it may cause some mild peeling or stinging when you first start using it.
Sources: [Journal of Drugs in Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35816067/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/28318351/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this cream go in a skincare routine for acne-prone skin?

This cream goes in the evening routine as a moisturizing treatment applied after cleansing and toning, and before a final layer of moisturizer if needed. Treatments with active ingredients are placed in the evening for simplicity and extra safety around sun exposure.

### Can I use this cream with vitamin C, and in what order?

You can use this cream with vitamin C by applying vitamin C in the morning and this cream at night, as using active ingredients separately helps lower the risk of skin irritation. This approach allows your skin to tolerate both products well while supporting a smooth and clear complexion.

### How often should I use this cream?

This cream is a great fit for your acne-prone skin and is used in the evening as a nighttime treatment. Its retinol and niacinamide help manage breakouts and regulate oil, while sodium hyaluronate and glycerin keep skin hydrated with a low risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is a great fit for acne-prone skin because niacinamide helps balance oil while retinol clears dead skin cells to manage breakouts. Sodium hyaluronate and glycerin add hydration to keep your skin healthy and strong, and the formula has a safe profile with a low likelihood of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream around the eyes or on my body?

This cream is generally suitable for the body, but the skin around the eyes is much thinner and may need extra caution with active ingredients like retinol. While the product has a safe profile, applying potent anti-aging treatments near the eyes can sometimes cause sensitivity.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol and parfum). Cetyl alcohol and oleyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for acne-prone skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — CA$24.99 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — CA$95.99 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/ca/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — CA$49.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/ca/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — CA$24.50 at Amazon

## Where to buy

- Amazon.ca: CA$41.00 (https://www.amazon.ca/dp/B0CNG2PF6Q?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Isostearyl Hydroxystearate, Niacinamide, Propanediol, Caprylic Capric Triglyceride, C14-22 Alcohols, Polymethylsilsesquioxane, Dimethicone, Cetyl Alcohol, Glyceryl Stearate, Hydrolyzed Yeast Extract, Isopropyl Palmitate, Retinol, Retinyl Propionate, Oleyl Alcohol, Sodium Hyaluronate, Serine, Hexyldecanol, Glycine Soja Extract Soybean Extract, Tocopheryl Acetate, Glycine Soja Soybean Sterols, Urea, Yeast Amino Acids, Trehalose, Inositol, Taurine, Betaine, Glycerin, Polyglucuronic Acid, C12-20 Alkyl Glucoside, Yam Root Extract, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Caprylyl Glycol, Swertia Chirata Extract, Lecithin, Pullulan, Disodium Phosphate, Potassium Phosphate, Peg-75 Stearate, Ceteth-20, Steareth-20, Cetyl Hydroxyethylcellulose, Phenoxyethanol, Ethylhexylglycerin, Picolinamide, Disodium Edta, Sodium Hydroxide, Hexylene Glycol, Sodium Benzotriazolyl Butylphenol Sulfonate, Ammonium Acryloyldimethyltaurate Vp Copolymer, Yellow 5 Ci 19140, Red 4 Ci 14700, Alpha-Isomethyl Ionone, Citronellol, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/murad/retinol-youth-renewal-night-cream/for/acne-prone-skin