# MISSHA The First Essence 5X for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [MISSHA](https://lovi.care/skincare/ca/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this essence utilizes yeast extract ferment and bifida lysate ferment to significantly enhance barrier resilience and smooth texture, while niacinamide helps regulate sebum production to address oily shine.
- The inclusion of glycerin and ceramide NP further supports hydration and barrier function, ensuring your skin remains comfortable and balanced.
- This formula is safe for your skin, containing no harsh ingredients and featuring soothing components like glycerin and niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Yeast Extract Ferment, Bifida Lysate Ferment, Ceramide Np, Extreme Α Ferment, Ct

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical moisturizers improved skin barrier function and surface moisture, while a postbiotic moisturizer with yeast extract uniquely supported microbiome balance and modulated biomarkers of skin barrier, structure, and inflammation in participants and ex vivo explants exposed to environmental aggressors. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/))
- A maintenance therapy with a cosmeceutical formulation containing hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid over 20 weeks significantly improved even skin tone, spot intensity, spot size, and overall hyperpigmentation in 33 healthy subjects with moderate facial dyspigmentation. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25844613/))
- A methanol yeast extract increases proliferation and migration while decreasing entrance into senescence and apoptosis phases in 3T3 fibroblast cells. ([Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/25898765/))
- Topically formulated tea polyphenols show some benefit in reducing sebum secretion and treating acne vulgaris compared to baseline or control. ([Antioxidants, 2016](https://pubmed.ncbi.nlm.nih.gov/28036057/))
- Topical application of tannase-converted green tea extract (TGE) significantly improved skin wrinkle indices and self-assessed wrinkle reduction compared to normal green tea extract (NGE) in human subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23725307/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))

## What reviewers say

Based on a very large amount of data, users consistently praise this essence for its lightweight, fast-absorbing hydration that visibly improves skin texture and radiance, often describing a healthy glow after consistent use. Some users report breakouts, likely due to fermented ingredients or niacinamide, and a segment of long-time fans express disappointment with the 5th generation reformulation, finding it less potent than previous versions.

- Liked: Lightweight & fast (mostly mentioned)
- Liked: Brightening & glow (often mentioned)
- Liked: Texture improvement (often mentioned)
- Liked: Gentle & fragrance-free (sometimes noted)
- Disliked: Reformulation disappointment (sometimes noted)
- Disliked: Breakouts & irritation (rarely noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Packaging quality (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Missha The First Essence 5X a great fit for combination skin?

Missha The First Essence 5X is a great fit for your combination skin because its yeast and bifida ferments smooth texture while niacinamide helps control oily shine. Glycerin and ceramide NP further support hydration to keep your skin balanced and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this essence a good fit for combination skin?

Yeast extract ferment and bifida lysate ferment make this essence a great fit because they smooth texture and strengthen your skin, while niacinamide helps control oily shine. Glycerin and ceramide NP further support hydration and keep your skin feeling comfortable and balanced.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Yeast Extract do for combination skin?

Yeast extract helps balance and hydrate combination skin while supporting the skin barrier against environmental stress. It may improve overall skin moisture and surface texture without causing irritation.
Sources: [Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/), [Food and Chemical Toxicology, 2008](https://pubmed.ncbi.nlm.nih.gov/18804142/)

### Where does it go in a skincare routine for combination skin?

This treatment goes in your evening routine after cleansing and before moisturizing. It uses yeast and bifida ferments to smooth texture and niacinamide to help keep oily shine under control.

### Can I use this essence with retinol, and in what order?

Yes, you can use this essence with retinol by applying the essence first to hydrate and soothe your skin before adding your retinol. This formula is safe and helps keep your skin comfortable and balanced while you use stronger treatments.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

You can use this treatment in the evening as part of your routine. It is safe for daily use and helps keep your combination skin balanced and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this essence clog pores, cause breakouts or purging for combination skin?

This essence is unlikely to cause breakouts, as very few reviewers report this issue and the formula is safe and gentle for combination skin. It contains soothing ingredients like glycerin and niacinamide that help keep skin calm and balanced.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [COSRX Galactomyces 95 Tone Balancing Essence](https://lovi.care/skincare/ca/p/cosrx/galactomyces-95-tone-balancing-essence/for/combination-skin) — Superior fit — CA$24.49 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr. Ceuracle Tea Tree Purifine 95 Essence](https://lovi.care/skincare/ca/p/dr-ceuracle/tea-tree-purifine-95-essence/for/combination-skin) — High fit — CA$48.14 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$43.00 (https://www.amazon.ca/dp/B09646RFWJ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Propanediol, 1,2-Hexanediol, Niacinamide, Yeast Extract Ferment, Diethoxyethyl Succinate, Bifida Lysate Ferment, Sodium Pca, Butylene Glycol, Ethylhexylglycerin, Adenosine, Xanthan Gum, Ceramide Np, Hydrogenated Lecithin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/the-first-essence-5x/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/the-first-essence-5x/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/the-first-essence-5x/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/combination-skin
- France: https://lovi.care/skincare/fr/p/missha/the-first-essence-5x/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/missha/the-first-essence-5x/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/the-first-essence-5x/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/missha/the-first-essence-5x/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/missha/the-first-essence-5x/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/the-first-essence-5x/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/the-first-essence-5x/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/the-first-essence-5x/for/combination-skin