# MEDIHEAL Collagen Ampoule Pad for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [MEDIHEAL](https://lovi.care/skincare/ca/brands/mediheal)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin, this product effectively addresses wrinkles and fine lines with collagen extract and peptides like Acetyl Hexapeptide-8, which stimulate collagen production and enhance skin elasticity. Glycerin and Hydroxyethyl Urea further support skin hydration, complementing the plumping effects.
- The inclusion of multiple peptides and collagen extract provides significant benefits for skin rejuvenation and minimizing the appearance of fine lines.
- The product is safe for your normal skin, as it contains no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/oily-acne-prone-skin): High

## Key ingredients

Collagen Extract, Adenosine, Ceramide Np, Betaine, Lactobacillus Ferment

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Collagen peptides induced cell proliferation and pro-collagen-1α expression, increased TGF-β and VEGF, and suppressed the LPS-induced inflammatory response in human skin fibroblasts and keratinocytes. ([Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/))
- Combined treatment with human umbilical cord mesenchymal stem cell-derived exosomes and hydrolyzed collagen oligopeptides enhanced proliferation and migration, reduced reactive oxygen species and senescence-associated beta-galactosidase activity, increased type I and type III collagen expression, and decreased metalloproteinases, inflammatory cytokines, and senescence markers in human skin fibroblasts compared to either treatment alone. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## What reviewers say

Based on a very large amount of data, users consistently praise these pads for their ability to deeply hydrate and plump the skin, often describing a "glass skin" effect that serves as an excellent base for makeup. They are highly effective for soothing redness and improving texture on sensitive skin. Some users note a sticky finish and a fragrance that may not suit everyone.

- Liked: Deep hydration & plumping (mostly mentioned)
- Liked: Generous essence (often mentioned)
- Liked: Versatile & convenient (often mentioned)
- Liked: High-quality pad (sometimes noted)
- Liked: Soothing & cooling (sometimes noted)
- Disliked: Noticeable fragrance (sometimes noted)
- Disliked: Lack of immediate glow (rarely noted)
- Disliked: Price and value (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Mediheal Collagen Pads a great fit for mature skin?

Mediheal Collagen Pads are a great fit for mature skin because they help smooth fine lines and boost firmness using collagen extract, peptides like Acetyl Hexapeptide-8, and hydrating glycerin. These ingredients support skin elasticity and moisture, leaving skin looking plump and well-cared-for.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this treatment a good fit for mature skin?

Collagen Extract, adenosine, and peptides like Acetyl Hexapeptide-8 make this treatment a great fit because they help smooth fine lines and boost skin elasticity. Glycerin and Hydroxyethyl Urea further support this by keeping the skin plump and hydrated.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Collagen Extract do for mature skin?

Collagen Extract helps keep mature skin feeling firm and smooth by supporting the natural collagen network and improving elasticity. It is unlikely to cause irritation and may reduce the appearance of fine lines while boosting overall moisture.
Sources: [International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/)

### What does Adenosine do for mature skin?

Adenosine helps smooth out wrinkles and keeps mature skin looking firm and well-hydrated. It supports collagen production to improve overall elasticity and reduce the look of lines.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/)

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in your evening routine, placed after cleansing and before your moisturizer. Using it at night is simple and provides extra safety around sun exposure, though some treatments can also be used in the morning or twice a day.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first to hydrate your skin and then following with retinol. Using a moisturizing formula with barrier-supporting ingredients helps reduce dryness and makes it easier for your skin to adjust to retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this treatment?

This treatment is best used in your evening routine, applying it once a day or up to twice a day if your skin tolerates it well. Regular use helps boost skin hydration, smooth fine lines, and improve elasticity.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh or irritating ingredients and has an excellent safety profile. It helps keep skin smooth and plump without feeling heavy.

### Can I use this treatment around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body because it has a gentle formula and is safe for normal skin. The thin skin around the eyes and various body areas benefit from its hydrating ingredients, which help smooth fine lines and keep the skin soft.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/ca/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/mature-skin) — Superior fit — CA$98.99 at Amazon
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ca/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/mature-skin) — High fit — CA$25.99 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/ca/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/mature-skin) — High fit — CA$99.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Amazon.ca: CA$31.45 (https://www.amazon.ca/dp/B0BHVF95S9?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Shoppers Drug Mart: CA$34.00 (https://www.shoppersdrugmart.ca/mediheal-collagen-ampoule-pad/p/BB_8800364100505?variantCode=8800364100505)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Glycereth-26, 1,2-Hexanediol, Diphenyl Dimethicone, Triethylhexanoin, Betaine, Hydroxyacetophenone, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Hydroxyethyl Urea, Dipotassium Glycyrrhizate, Sodium Citrate, Allantoin, Octyldodeceth-16, Xanthan Gum, Hydroxyethylcellulose, Collagen Extract, Adenosine, Citric Acid, Disodium Edta, Olea Europaea Oil Fruit Olive Oil Fruit, Butylene Glycol, Pelargonium Graveolens Oil Flower, Lavandula Angustifolia Oil Lavender Oil, Anthemis Nobilis Oil Flower, Citrus Aurantium Dulcis Peel Oil, Juniperus Mexicana Oil, Mangifera Indica Fruit Extract, Lactobacillus Ferment, Ceramide Np, Extract Milk Protein, Caprylyl Glycol, Tripeptide-1, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/collagen-ampoule-pad/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/collagen-ampoule-pad/for/mature-skin
- France: https://lovi.care/skincare/fr/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/mediheal/collagen-ampoule-pad/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/collagen-ampoule-pad/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/collagen-ampoule-pad/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/collagen-ampoule-pad/for/mature-skin