# Mediheal A:PE Protain Mask for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Mediheal](https://lovi.care/skincare/ca/brands/mediheal)
Category: [Face masks](https://lovi.care/skincare/ca/best/face-masks)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few nourishing masks fit it even better.

## Why this fit

- Excellent suitability for your normal skin is provided by niacinamide and glycerin, which offer humectant action and barrier repair. The presence of milk protein and acetyl hexapeptide-8 in high concentrations further enhances skin repair and rejuvenation, offering excellent nourishing mask benefits.
- Moderate benefits for pigmentation are addressed with niacinamide and Dipotassium Glycyrrhizate, which are moderately effective ingredients for this concern.
- The product is safe for your normal skin due to the absence of prohibited or harsh ingredients, posing no risks of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Hydrolyzed Collagen, Sodium Hyaluronate, Centella Asiatica Extract, Squalane

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users with dry, sensitive, or compromised skin barriers report excellent outcomes, praising the mask for its rich, creamy essence that deeply moisturizes and calms redness. While highly effective for soothing irritation and flattening pimples, the heavy, milky texture can be too rich or sticky for those with oily or acne-prone skin.

- Liked: Rich hydration (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Soft adherent sheet (often mentioned)
- Disliked: Heavy sticky finish (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Disliked: Artificial fragrance (rarely noted)
- Disliked: Fit issues (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using the sheet mask 3 times a week and move to daily use if your skin likes it.
- Apply the sheet mask after cleansing and toning, but before putting on your moisturizer or SPF.
- Place the sheet mask smoothly over your face and gently press it to help the ingredients soak in.
- For the best results, put the sheet mask on clean and slightly damp skin.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/cf9cbc1593b43309df7ca9cfe4fbbdae.mp4

## Questions and answers

### What makes the Mediheal A:PE Protain Mask a great fit for skin with dark spots?

This mask is a great fit because it contains niacinamide and dipotassium glycyrrhizate, which help fade dark spots. Niacinamide lightens pigmentation by slowing down pigment transfer, and the product is safe and unlikely to cause irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this mask a good fit for skin with dark spots?

Niacinamide and dipotassium glycyrrhizate make this mask a good fit for skin with dark spots. Niacinamide helps reduce dark spots by slowing down pigment transfer in the skin, while being well tolerated.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Hydrolyzed Collagen do for skin with dark spots?

Hydrolyzed collagen helps improve overall skin health and texture, but for dark spots, a product of this type needs added brightening ingredients like vitamin C or niacinamide to help fade discoloration.
Sources: [Cureus, 2023](https://pubmed.ncbi.nlm.nih.gov/38192916/), [International Journal of Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33742704/)

### Where does this mask go in a skincare routine for skin with dark spots?

This nourishing mask goes into your weekly evening routine, right after cleansing and an enzyme powder, and before your treatment and moisturizer. It is a great fit for skin with dark spots because it contains niacinamide and dipotassium glycyrrhizate, which help fade pigmentation while repairing the skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Can I use this mask with retinol, and in what order?

Yes, you can use this mask alongside retinol by applying the mask after your retinol treatment to help keep skin calm and hydrated. The product has a very safe formula that is unlikely to cause irritation.

### How often should I use this mask?

This nourishing mask is designed for weekly use as part of your routine for skin with dark spots. Its ingredients help improve skin moisture and barrier function while being gentle on normal skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this mask clog pores, cause breakouts or purging for skin with dark spots?

This mask is unlikely to clog pores or cause breakouts for skin with dark spots because it is safe for your skin with the absence of harsh ingredients.

### Is this mask fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for skin with dark spots

- [Anua Heartleaf 77% Soothing Sheet Mask](https://lovi.care/skincare/ca/p/anua/heartleaf-77-soothing-sheet-mask/for/dark-spots) — Superior fit — CA$10.00 at Amazon
- [Mediheal Watermide Essential Mask](https://lovi.care/skincare/ca/p/mediheal/watermide-essential-mask/for/dark-spots) — Superior fit — CA$29.00 at Amazon
- [Pyunkang Yul Ceramide Calming Mask Pack](https://lovi.care/skincare/ca/p/pyunkang-yul/ceramide-calming-mask-pack/for/dark-spots) — High fit — CA$25.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/ca/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — CA$23.99 at Amazon
- Moisturizer: [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/ca/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/dark-spots) — High fit — CA$98.99 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Dipropylene Glycol, Niacinamide, Propylene Glycol, Cetearyl Alcohol, Squalane, Glycerin, Hydrogenated Lecithin, C12-16 Alcohols, Palmitic Acid, Dipotassium Glycyrrhizate, Lactobacillus Eriodictyon Californicum Extract Ferment, Lactobacillus Soybean Extract Ferment, Centella Asiatica Extract, Origanum Vulgare Leaf Extract, Cinnamomum Cassia Bark Extract, Vitex Agnus Castus Extract, Chamomilla Recutita Extract Matricaria Extract, Chamaecyparis Obtusa Leaf Extract, Peg-12 Dimethicone, Hydroxyethyl Urea, Willow Bark Extract, Scutellaria Baicalensis Root Extract, Betaine, Bifida Ferment Filtrate, Pentylene Glycol, Xylitylglucoside, Adenosine, Anhydroxylitol, Leontopodium Alpinum Callus Culture Extract, Xylitol, Dimethicone, Extract Milk Protein, Tocopheryl Acetate, Hydrolyzed Collagen, Sodium Hyaluronate, Glucose, Portulaca Oleracea Extract, Butylene Glycol, Glycine, Serine, Glutamic Acid, Aspartic Acid, Leucine, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Valine, Threonine, Proline, Isoleucine, Histidine, Methionine, Cysteine, Acetyl Hexapeptide-8, Phenoxyethanol, Copper Tripeptide-1, Ethylhexylglycerin, Disodium Edta, Carbomer, 1,2-Hexanediol, Zanthoxylum Piperitum Fruit Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/a-pe-protain-mask/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/a-pe-protain-mask/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/mediheal/a-pe-protain-mask/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/mediheal/a-pe-protain-mask/for/dark-spots
- France: https://lovi.care/skincare/fr/p/mediheal/a-pe-protain-mask/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/mediheal/a-pe-protain-mask/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/a-pe-protain-mask/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/mediheal/a-pe-protain-mask/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/mediheal/a-pe-protain-mask/for/dark-spots (this page)
- Australia: https://lovi.care/skincare/au/p/mediheal/a-pe-protain-mask/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/mediheal/a-pe-protain-mask/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/a-pe-protain-mask/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/a-pe-protain-mask/for/dark-spots