# Medicube Super Cica Ampoule for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medicube](https://lovi.care/skincare/ca/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your combination skin and oily shine is provided by Centella Asiatica Extract and Madecassoside, which effectively calm redness and help control oil production.
- Licorice root extract and panthenol further support skin soothing and barrier repair, enhancing overall skin comfort and resilience.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Madecassoside, Asiatic Acid, Madecassic Acid, Extract Tree

## What the research says

- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))

## What reviewers say

This ampoule is highly effective for users with acne-prone and sensitive skin, frequently noted for its rapid soothing of redness and calming of active breakouts, acting as a significant aid for compromised skin barriers. A notable portion of users express dissatisfaction with its sticky or tacky finish, which can be problematic for morning routines and makeup application.

- Liked: Soothing & calming (mostly mentioned)
- Liked: Acne & blemish care (often mentioned)
- Disliked: Small quantity/price (often mentioned)
- Disliked: Sticky texture (often mentioned)
- Liked: Hydration & glow (sometimes noted)
- Disliked: Packaging/dropper issues (sometimes noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Super Cica a great fit for combination skin?

Medicube Super Cica Ampoule is a great fit because centella asiatica extract and madecassoside calm redness and help control oily shine on combination skin. Licorice root extract and panthenol further support skin soothing and barrier repair, leaving your face comfortable without any risk of irritation.
Sources: [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for combination skin?

Centella asiatica extract and madecassoside make this serum a great fit by effectively calming redness and helping control oily shine on combination skin. Licorice root extract and panthenol further support skin soothing and barrier comfort.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### What does Centella Asiatica Extract do for combination skin?

Centella Asiatica Extract helps balance combination skin by boosting moisture levels while keeping redness and irritation calm. It also supports skin barrier repair to help maintain smooth and healthy skin overall.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Madecassoside do for combination skin?

Madecassoside helps keep combination skin calm and hydrated while supporting the skin barrier. It may also improve moisture balance and reduce irritation in areas that tend to be dry or flaky.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening keeps things simple and adds safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the retinol first, letting it absorb, and then following with this serum to help calm redness and support your skin barrier. This product is unlikely to cause irritation because it contains soothing ingredients like Centella Asiatica Extract and panthenol.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### How often should I use this serum?

This treatment is great for your combination skin because Centella Asiatica extract and madecassoside calm redness and help control oil. You can use it in your evening routine, and it is safe and unlikely to cause irritation.
Sources: [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is a great fit for combination skin because centella asiatica extract and madecassoside help calm redness and control oily shine without clogging pores. The formula is safe for your skin with no harsh ingredients, making it very unlikely to cause breakouts or purging.
Sources: [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Centella Asiatica Extract, Water, Glycerin, Butylene Glycol, Methylpropanediol, Glycereth-26, 1,2-Hexanediol, Betaine, Licorice Root Extract, Carbomer, Tromethamine, Glycereth-25 Pca Isostearate, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Allantoin, Glyceryl Acrylate Acrylic Acid Copolymer, Dipropylene Glycol, Panthenol, Gardenia Extract, Adenosine, Propanediol, Polyglyceryl-10 Oleate, Centella Asiatica Root Extract, Centella Asiatica Leaf Extract, Nelumbo Nucifera Extract, Pentylene Glycol, Tree Leaf Water, Madecassoside, Biosaccharide Gum-1, Extract Tree, Asiatic Acid, Madecassic Acid, Asiaticoside, Ectoin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/super-cica-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/super-cica-ampoule/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/super-cica-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medicube/super-cica-ampoule/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/super-cica-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medicube/super-cica-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medicube/super-cica-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/super-cica-ampoule/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/super-cica-ampoule/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/super-cica-ampoule/for/combination-skin