# Medicube PDRN Pink Peptide Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medicube](https://lovi.care/skincare/ca/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent for your normal skin, this serum effectively targets wrinkles and fine lines with peptides like Acetyl Hexapeptide-8 and Copper Tripeptide-1, which promote collagen synthesis and elasticity. Niacinamide and hyaluronic acid further enhance hydration and barrier repair, complementing your skin's needs.
- The inclusion of sodium DNA and adenosine contributes to overall skin rejuvenation and plumping, offering comprehensive benefits for your concerns.
- This formula is safe for your normal skin, as it contains no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Hydrolyzed Collagen, Sodium Dna

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for delivering intense hydration and a radiant "glass skin" glow, with users frequently reporting immediate improvements in skin plumpness and elasticity. The viscous texture is often noted for its barrier-repairing qualities. A polarizing feature is the distinct scent, described as floral and fishy, which some users find unpleasant.

- Liked: Deep hydration (mostly mentioned)
- Liked: Radiant glow (often mentioned)
- Liked: Smoother texture (often mentioned)
- Liked: Soothing and gentle (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Small quantity (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes medicube Pink Peptide Serum a great fit for mature skin?

This serum is a great fit for mature skin because it targets wrinkles and fine lines with peptides like Acetyl Hexapeptide-8 and Copper Tripeptide-1, which help boost collagen and firmness. Niacinamide and hyaluronic acid also improve hydration and strengthen the skin barrier, while sodium DNA and adenosine plump and rejuvenate the skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it uses peptides like Acetyl Hexapeptide-8 and Copper Tripeptide-1 to help smooth wrinkles and boost firmness. Ingredients like Niacinamide, hyaluronic acid, and sodium DNA also work to deeply hydrate the skin, repair the moisture barrier, and plump up fine lines.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Hydrolyzed Collagen do for mature skin?

Hydrolyzed collagen helps reduce wrinkles and improves skin elasticity and moisture in mature skin. Regular intake supports skin density and smoothness while helping to prevent the breakdown of natural collagen.
Sources: [International Journal of Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33742704/), [Nutrients, 2023](https://pubmed.ncbi.nlm.nih.gov/37432180/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Using it at night helps the peptides and sodium DNA smooth fine lines and plump up mature skin.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to boost hydration and help smooth fine lines, followed by your retinol. This pairing is generally safe and helps keep mature skin soft and plump.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### How often should I use this serum?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure, and some formulas may also be used in the morning or twice a day. Regular daily application helps improve fine lines, wrinkles, and skin moisture over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts for mature skin because its formula avoids harsh and irritating ingredients, and user complaints about breakouts are low. It helps keep skin smooth and soft while supporting your skin barrier without clogging pores.

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes, though the skin there is much thinner than on the body, because its gentle formula with peptides and hyaluronic acid helps smooth fine lines safely and effectively.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ca/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/mature-skin) — High fit — CA$25.99 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — CA$37.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — CA$21.81 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Amazon.ca: CA$22.00 (https://www.amazon.ca/dp/B0DBF65JYY?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Shoppers Drug Mart: CA$29.00 (https://www.shoppersdrugmart.ca/medicube-pdrn-pink-collagen-glow-jelly-mist-serum/p/BB_8800289478772?variantCode=8800289478772)
Prices checked 10 Oct – 3 Nov 2026.

## Ingredients

Water, Disodium Edta, Niacinamide, Hydrolyzed Collagen, Sodium Dna, Milt Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, 1,2-Hexanediol, Glycerin, Dipropylene Glycol, Polyglycerin-3, Glyceryl Acrylate Acrylic Acid Copolymer, Pvm Ma Copolymer, Hyaluronic Acid, Ethylhexylglycerin, Glycereth-26, Adenosine, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isopropyl Myristate, Ubiquinone, Caprylyl Glycol, Tromethamine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Caprylyl Capryl Glucoside, Sorbitan Oleate, Atelocollagen, Salmon Egg Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-serum/for/mature-skin