# Medicube PDRN Pink Peptide Ampoule for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medicube](https://lovi.care/skincare/ca/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for your oily skin, as niacinamide helps regulate sebum and repair the skin barrier, while hyaluronic acid provides hydration. However, the formula is not specifically targeted to address your concerns with acne, blemishes, and breakouts.
- The peptide complex and adenosine offer general anti-aging and plumping effects, which are supportive but not primary for your stated goals.
- The product is safe for your oily skin, with no reported irritation risks due to the absence of harsh ingredients and the inclusion of soothing components like hyaluronic acid and niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))

## Why other moisturizers fit oily acne-prone skin better

- Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients. ([The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/))
- A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28342238/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))

## What reviewers say

Based on a very large amount of data, users consistently report that this ampoule delivers a "glass skin" effect, providing deep hydration and a noticeable plumping effect that benefits dry and aging skin. While it is widely praised for smoothing texture and soothing sensitive skin, results regarding blemish fading are mixed and take longer to appear.

- Disliked: Deep hydration (mostly mentioned)
- Disliked: Radiant glow (mostly mentioned)
- Disliked: Fast absorption (often mentioned)
- Liked: Noticeable fragrance (sometimes noted)
- Liked: Small volume (sometimes noted)
- Disliked: Soothing and gentle (sometimes noted)
- Liked: Minor breakouts (rarely noted)
- Liked: Slight stickiness (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does medicube PDRN Pink Peptide Ampoule work for oily acne-prone skin?

This ampoule works moderately well for oily skin by helping control oil and adding hydration, but it does not specifically target breakouts and blemishes. A product for this skin type needs lightweight ingredients that balance oil, provide non-greasy moisture, and target acne without clogging pores.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Niacinamide helps regulate oil and repair the skin barrier, while hyaluronic acid provides hydration without irritation. However, an ideal product for oily acne-prone skin also needs ingredients that specifically target breakouts and blemishes while remaining lightweight and non-clogging.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Salmon Pdrn do for oily acne-prone skin?

Salmon PDRN helps improve oily acne-prone skin by enhancing overall skin condition and supporting tissue recovery through cellular mechanisms. It is unlikely to clog pores and may help calm inflammation when used as part of your regular routine.
Sources: [Pharmaceutics, 2025](https://pubmed.ncbi.nlm.nih.gov/40871045/)

### What does Salmon Collagen do for oily acne-prone skin?

Salmon Collagen is unlikely to be a good fit for oily acne-prone skin because it generally targets dry skin and wrinkles rather than controlling oil or breakouts. To properly care for oily acne-prone skin, this type of product needs ingredients that clear pores and balance oil without clogging the skin.
Sources: [Nutrients, 2026](https://pubmed.ncbi.nlm.nih.gov/42451143/), [Journal of Drugs in Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30681787/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, following Lovi routines that put active serums in the evening for simplicity and safety around sun exposure. It is safe for oily skin and unlikely to cause irritation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin hydration and soothing benefits before your retinol step. This product is safe for your oily skin and is unlikely to cause irritation when combined this way, though an acne treatment specifically formulated to target breakouts and blemishes would fit your skin better.

### How often should I use this serum?

This serum works well in your evening routine, where you can use it once a day to keep your skin hydrated and supported. It is safe for daily use on oily skin, though an oily acne-prone skin type needs a product that specifically targets breakouts and blemishes with clarifying ingredients.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause irritation on oily skin, as it is free of harsh ingredients and includes soothing components like niacinamide and hyaluronic acid. However, because the formula does not specifically target blemishes, oily acne-prone skin needs products with acne-fighting ingredients like salicylic acid or benzoyl peroxide to properly manage breakouts.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Can I use this serum around the eyes or on my body?

You can use this serum safely around the eyes, where the skin is particularly thin, as well as on the body. Its gentle moisturizing ingredients are unlikely to cause irritation in delicate areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/oily-acne-prone-skin) — Superior fit — CA$21.81 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/oily-acne-prone-skin) — Average fit — CA$37.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

- Amazon.ca: CA$15.87 (https://www.amazon.ca/dp/B0G11L8F7C?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone, Ocimum Tenuiflorum, Hyaluronic Acid, Niacinamide, Curcuma Longa Root Extract, Adenosine, Ocimum Sanctum Leaf Extract, Peptide Complex, Rose Pdrn Extract Rosa Damascena Sodium Dna Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin