# Medicube One Day Exosome Shot 7500 for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medicube](https://lovi.care/skincare/ca/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate rejuvenation for your normal skin, as Lactobacillus Extracellular Vesicles and Niacinamide promote skin repair and improve tone, while Adenosine supports collagen production to address wrinkles and fine lines.
- Panthenol provides humectant action, enhancing barrier repair for your normal skin type.
- The product is safe for your skin due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin): Average

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Adenosine, Betaine Salicylate, Oenothera Biennis Flower Extract

## What the research says

- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))

## What reviewers say

Users frequently report a "glass skin" effect with noticeable improvements in skin texture and pore size after overnight use, though the application involves a distinct prickly sensation due to the spicules. While highly effective for smoothing and tightening, it is polarizing due to the "needle-like" pain and potential for irritation on sensitive skin.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Painful application (mostly mentioned)
- Liked: Fast/overnight results (often mentioned)
- Liked: Visible pore reduction (often mentioned)
- Liked: Enhanced product absorption (sometimes noted)
- Disliked: Not for sensitive skin (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: High price point (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Exosome Shot 7500 work for mature skin?

This treatment works moderately well for mature skin, helping to repair the skin, improve tone, and smooth out fine lines. A product for this skin type needs potent antioxidants, deeply hydrating components, and ingredients that support elasticity and collagen production to deliver optimal anti-aging results.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/)

### Which ingredients make this serum a good fit for mature skin?

This treatment is a fair fit for mature skin because Lactobacillus Extracellular Vesicles and niacinamide help repair the skin and even out tone, while adenosine supports collagen production to smooth fine lines and wrinkles. To be a better fit for this skin type, a product needs exceptionally safe, high concentrations of potent antioxidants, peptides, and hydrating ingredients that deeply improve elasticity and moisture retention without any risk of irritation.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/)

### What do Lactobacillus Extracellular Vesicles do for mature skin?

Lactobacillus extracellular vesicles help strengthen the skin barrier by boosting key proteins that keep moisture locked in, which makes dry or aging skin feel soft and smooth. This ingredient is unlikely to irritate, though results may vary depending on your skin type.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40356846/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though mature skin often needs products packed with rich hydrators and firming peptides to fully target fine lines and loss of firmness.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol, but apply them on alternating nights to keep your skin calm and avoid irritation. Because this formula provides only moderate care for mature skin, a well-rounded routine for this skin type also needs ingredients like ceramides and peptides to fully support collagen and barrier strength.

### How often should I use this serum?

Use this treatment once a week in your evening routine to start, and if your skin tolerates it well and you see good results, you can carefully use it more often. Mature skin needs products with antioxidants, gentle exfoliants, and ingredients that support collagen production to smooth fine lines and improve tone.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts for mature skin, though reviewers frequently mention painful application and moderate skin irritation. To properly support mature skin, products of this type need ingredients that boost collagen production, improve tone, and deeply restore moisture.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/mature-skin) — High fit — CA$14.40 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/mature-skin) — High fit — CA$27.99 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

- Amazon.ca: CA$27.44 (https://www.amazon.ca/dp/B0D137TMRB?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-7500/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/mature-skin