# Medicube One Day Exosome Shot 2000 for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medicube](https://lovi.care/skincare/ca/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your oily skin is provided by niacinamide for seboregulation and betaine salicylate for keratolytic action, promoting skin regeneration and chemical exfoliation.
- Glycerin and panthenol offer general skincare benefits like hydration, which are supportive for your oily shine concerns.
- The product is safe for your oily skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin): High

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Adenosine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))
- Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline. ([Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/15608997/))
- Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity. ([International Journal of Pharmaceutics, 2008](https://pubmed.ncbi.nlm.nih.gov/18761396/))
- A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation. ([Chemical & Pharmaceutical Bulletin, 2010](https://pubmed.ncbi.nlm.nih.gov/20190449/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

This ampoule is highly praised for its ability to refine skin texture and minimize pores, leading to smoother skin and a glow. While a tingling sensation from spicules is frequently noted and can be uncomfortable for some, most users experience visible improvements in smoothness and reduced blackheads within weeks. Some users with sensitive skin may experience irritation or dryness.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Prickly/tingling sensation (mostly mentioned)
- Liked: Pore tightening (often mentioned)
- Liked: Blackhead reduction (sometimes noted)
- Liked: Fast results (sometimes noted)
- Disliked: Can be drying (rarely noted)
- Disliked: Skin irritation/breakouts (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube One Day Exosome Shot 2000 a great fit for oily skin?

This treatment is a great fit for your oily skin because niacinamide helps balance oil production while betaine salicylate gently clears away dead skin cells to keep pores clear. Glycerin and panthenol add light hydration, and the formula is safe and unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this treatment a good fit for oily skin?

Niacinamide helps balance oil, while betaine salicylate provides gentle chemical exfoliation to support skin renewal. Glycerin and panthenol add light hydration, and the formula is safe and unlikely to cause irritation on oily skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What do Lactobacillus Extracellular Vesicles do for oily skin?

Lactobacillus extracellular vesicles help calm irritated skin and support a balanced skin barrier. They are unlikely to clog pores and may reduce redness or inflammation in oily skin types.
Sources: [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/), [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41175997/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this treatment go in a skincare routine for oily skin?

This treatment goes in your evening routine, placed after cleansing and toning and before your moisturizer. Putting it in the evening helps keep things simple and adds extra safety around sun exposure, though some treatments may also be used in the morning or twice a day.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying it in your evening routine, as long as you introduce them slowly to avoid irritation. It is unlikely to cause discomfort when paired carefully, since the formula is gentle and well-tolerated by oily skin.

### How often should I use this treatment?

You can use this treatment in your evening routine, starting just once a week. If your skin handles it well and you see good results, you may carefully use it more often.

### Can this treatment clog pores, cause breakouts or purging for oily skin?

This treatment is unlikely to clog pores or cause breakouts on oily skin, as it has a very low risk of irritation and features niacinamide and betaine salicylate to help balance oil and gently clear away dead skin cells. While reviewers often note a prickly or tingling sensation during use, complaints about breakouts remain low.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-skin) — High fit — CA$27.99 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-skin) — High fit — CA$24.44 at Amazon
- [ANUA PEACH 70% NIACINAMIDE SERUM](https://lovi.care/skincare/ca/p/anua/peach-70-niacinamide-serum/for/oily-skin) — High fit — CA$33.50 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$28.49 (https://www.amazon.ca/dp/B0DQCJ9T9N?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/oily-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-2000/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-2000/for/oily-skin