# medicube Exosome Cica Calming Toner for mature skin

**Lovi Fit: Low fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [medicube](https://lovi.care/skincare/ca/brands/medicube)
Category: [Toners](https://lovi.care/skincare/ca/best/toners)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for mature skin; the toners alongside fit it better.

## Why this fit

- Offers moderate soothing and hydration for your normal skin, as Centella Asiatica Extract and Glycerin provide anti-inflammatory and humectant benefits, but these ingredients do not specifically target wrinkles and fine lines.
- The presence of Heart Leaf Extract further enhances the calming effects, making it suitable for general skin comfort.
- The formula is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/mature-skin): Low (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Exosome, Heart Leaf Extract

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A hyperoside-enriched fraction of Houttuynia cordata Thunb. inhibited UVB-induced oxidative stress, inflammation, and collagen degradation in human dermal fibroblasts by regulating the MAPK signaling pathway. ([Plants, 2021](https://pubmed.ncbi.nlm.nih.gov/34961096/))
- Houttuynia cordata extract containing hyperoside and quercitrin protected human HaCaT keratinocytes from UVB-induced cell damage, apoptosis, oxidative stress, and inflammation by modulating MAPKs and Akt signaling pathways. ([Antioxidants, 2022](https://pubmed.ncbi.nlm.nih.gov/35204104/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Adjuvant application of human adipose tissue stem cell-derived exosomes gel following fractional CO2 laser significantly improved the reduction of acne scars (32.5% vs 19.9%, p < 0.01) and reduced erythema and downtime in 25 patients compared to the control gel. ([Acta Dermato-venereologica, 2020](https://pubmed.ncbi.nlm.nih.gov/33073298/))
- Topical mesenchymal stem cell-derived exosomes reduced Ocular Surface Disease Index scores, increased tear secretion, lowered fluorescein scores, prolonged tear-film break-up time, increased Epidermal Growth Factor and thrombospondin-1, and decreased interleukin-6 and Matrix metalloproteinase-9 in patients with Sjögren's syndrome-related dry eye compared to phosphate buffered saline control. ([BMC Ophthalmology, 2025](https://pubmed.ncbi.nlm.nih.gov/40394561/))
- Topical human platelet extract exosome serum improved skin health scores and reduced redness, wrinkles, and melanin production while enhancing luminosity and color evenness at 6 weeks. ([Aesthetic Surgery Journal, 2022](https://pubmed.ncbi.nlm.nih.gov/35689936/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))

## Why other toners fit mature skin better

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Apigenin protects against UVA-induced cytotoxicity and senescence in normal human dermal fibroblasts, decreases MMP-1 expression, and when applied topically as a cream in human subjects, increases dermal density and elasticity while reducing fine wrinkle length, skin evenness, moisture content, and transepidermal water loss compared to control cream. ([International Journal of Molecular Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27279007/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))

## What reviewers say

This toner is highly praised for its lightweight, watery texture that absorbs quickly without stickiness, making it suitable for oily and acne-prone skin. It is very effective at reducing redness and soothing irritation, with many users reporting improved skin balance. Some users noted concerns about the scent, price, and potential for fungal acne, though these were less common observations.

- Liked: Calms redness (mostly mentioned)
- Liked: Lightweight absorption (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Improves acne (sometimes noted)
- Disliked: Not fungal acne safe (rarely noted)
- Disliked: Price point (rarely noted)
- Disliked: Scent preferences (rarely noted)
- Disliked: Unclear long-term benefits (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and move to daily use if your skin tolerates it well.
- Apply this soothing toner right after cleansing and before your moisturizer or SPF .
- Gently press 2-3 drops of the soothing toner into your skin and let it absorb for a minute.
- Apply the soothing toner on slightly damp skin to help with better absorption.
- Avoid the sensitive eye area and do a patch test before your very first use .
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### Why is medicube Exosome Cica Calming Toner a weak match for mature skin?

This soothing toner is a weak match because its Centella Asiatica Extract and glycerin only provide general calming and hydration without specifically targeting wrinkles and fine lines. A soothing toner for mature skin needs effective soothing ingredients that address wrinkles and fine lines while supporting the skin barrier.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this toner a poor fit for mature skin?

This toner is a weak match for mature skin because it lacks specific ingredients to target wrinkles and fine lines, offering only general soothing and hydration. A product of this type needs effective soothing ingredients that provide excellent benefits for addressing aging concerns while supporting the skin barrier.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Centella Asiatica Extract do for mature skin?

Centella Asiatica Extract helps mature skin by improving moisture, reducing moisture loss, and supporting collagen production to keep skin firm and smooth. It also provides antioxidant and calming benefits that help protect against everyday stress and visible signs of aging.
Sources: [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/)

### What do Exosomes do for mature skin?

Exosomes help mature skin by improving firmness, smoothing out wrinkles, and boosting hydration. They also help calm redness and even out skin tone to give you a more glowing look.
Sources: [Dermatology Practical & Conceptual, 2026](https://pubmed.ncbi.nlm.nih.gov/41912205/), [Aesthetic Surgery Journal, 2022](https://pubmed.ncbi.nlm.nih.gov/35689936/)

### Where does this toner go in a skincare routine for mature skin?

This toner goes right after cleansing in the morning routine, helping to keep skin calm and hydrated. Mature skin needs products with targeted anti-aging ingredients like peptides or antioxidants to specifically smooth fine lines and wrinkles.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this toner with retinol, and in what order?

You can use this toner with retinol by applying it right after cleansing to calm and hydrate your skin before putting on your retinol treatment. This product is safe and unlikely to cause irritation, though a toner for mature skin also needs ingredients that smooth fine lines and target wrinkles.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this toner?

You can use this soothing toner daily in the morning and evening for general comfort and hydration, as it is safe for your skin. Because it does not target fine lines, mature skin needs a routine with ingredients like peptides and antioxidants to improve firmness and smooth wrinkles.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this toner clog pores, cause breakouts or purging for mature skin?

This toner is unlikely to clog pores or cause breakouts for mature skin because its gentle formula is safe and free of harsh ingredients. To properly care for mature skin, a product of this type needs firming ingredients and antioxidants that target wrinkles and fine lines.

## Alternatives for mature skin

- [Fundamental Soothing Toner](https://lovi.care/skincare/ca/p/fundamental/soothing-toner/for/mature-skin) — High fit — CA$29.99 at Amazon
- [La Roche-Posay Soothing Lotion Sensitive Skin Toner](https://lovi.care/skincare/ca/p/la-roche-posay/soothing-lotion-sensitive-skin/for/mature-skin) — Average fit — CA$34.85 at Amazon

## Routine for mature skin

### AM

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — CA$27.34 at Amazon

### PM

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/ca/p/pyunkang-yul/deep-cleansing-oil/for/mature-skin) — Superior fit — CA$23.99 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Cleansing Toner: [Pixi Glow Tonic](https://lovi.care/skincare/ca/p/pixi/glow-tonic/for/mature-skin) — Superior fit — CA$28.90 at Amazon
- Serum or Treatment: [SKIN1004 Madagascar Centella Poremizing Fresh Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-poremizing-fresh-ampoule/for/mature-skin) — Superior fit — CA$22.09 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

### Weekly

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/ca/p/pyunkang-yul/deep-cleansing-oil/for/mature-skin) — Superior fit — CA$23.99 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ca/p/dermalogica/daily-microfoliant/for/mature-skin) — High fit — CA$29.50 at Amazon
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/ca/p/mediheal/vita-essential-mask/for/mature-skin) — Superior fit — CA$29.99 at Amazon
- Serum or Treatment: [SKIN1004 Madagascar Centella Poremizing Fresh Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-poremizing-fresh-ampoule/for/mature-skin) — Superior fit — CA$22.09 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Centella Asiatica Extract, Exosome, Heart Leaf Extract, Extract Tree, Glycerin, Butylene Glycol, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/exosome-cica-calming-toner/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/exosome-cica-calming-toner/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/exosome-cica-calming-toner/for/mature-skin