# Medicube EXOSOME CICA CALMING PAD for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medicube](https://lovi.care/skincare/ca/brands/medicube)
Category: [Toners](https://lovi.care/skincare/ca/best/toners)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other toners fit it better.

## Why this fit

- Offers moderate soothing for your dry skin as exosome cica and niacinamide provide supportive hydration and barrier repair, calming redness and reducing flakiness.
- The formula is generally safe for your dry skin, as it lacks harsh ingredients that could cause irritation.
- While beneficial for general soothing, the product lacks sufficient emollient and occlusive ingredients for optimal hydration for your dry skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin): Average

## Key ingredients

Exosome Cica, Tree, Niacinamide

## What the research says

- Combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling significantly improved skin wrinkles, elasticity, hydration, and pigmentation compared to microneedling alone in twenty-eight individuals with facial skin aging. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37377400/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Dermocosmetic loaded with plant extract significantly improved skin texture and surface parameters including roughness, scaliness, smoothness, and wrinkles compared to a base without extract in Asian male volunteers over three months. ([Pakistan Journal of Pharmaceutical Sciences, 2020](https://pubmed.ncbi.nlm.nih.gov/32276894/))
- A cosmetic cream containing Harungana madagascariensis plant extract induces similar anti-aging effects to a retinol-containing cream on 46 human subjects, improving wrinkles, ptosis, color homogeneity, smoothness, plumpness, firmness, and elasticity. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37155516/))
- An OTC topical formulation containing a plant extract complex improved skin extensibility and firmness significantly (P < 0.02) compared to placebo in 20 volunteers, with no adverse reactions. ([International Journal of Cosmetic Science, 2000](https://pubmed.ncbi.nlm.nih.gov/18503475/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))

## Why other toners fit dry skin better

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- A formulation containing glycerol (5%) and xylitol (5%) applied twice daily for 14 days increased skin hydration, filaggrin protein quantity, interdigitation index, and biomechanical properties, and decreased transepidermal water loss compared to untreated and vehicle-treated skin in twelve volunteers with dry skin. ([Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/))

## What reviewers say

Based on a very large amount of data, users with sensitive and acne-prone skin frequently praise these pads for their immediate cooling and redness-reducing effects, often noting significant relief from facial heat and irritation. While most find them highly hydrating and effective for smoothing skin texture, a minority of users felt they were less effective for active blemishes or found the pad material slightly rough.

- Liked: Rapid soothing cooling (mostly mentioned)
- Liked: Hydrating non-sticky (often mentioned)
- Liked: Generous essence (sometimes noted)
- Liked: Gentle exfoliation (sometimes noted)
- Liked: High adherence (sometimes noted)
- Disliked: High price point (rarely noted)
- Disliked: Ineffective on acne (rarely noted)
- Disliked: Pad texture rough (rarely noted)
- Disliked: Strong scent (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using your soothing toner 3 times a week and move to daily use if your skin likes it.
- Apply your soothing toner after cleansing, and before putting on your moisturizer or SPF.
- Gently press 2-3 drops of the soothing toner into your skin with your hands. Let it absorb for a minute before adding your next product.
- Apply the soothing toner on slightly damp skin to help it absorb better. This works great for dry or flaky skin to lock in extra moisture.
- Avoid the sensitive eye area when applying the soothing toner. Do a quick patch test before your very first use to be safe.
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### How well does medicube Exosome Cica Calming Pad work for dry skin?

This soothing toner offers moderate relief for your dry skin by providing supportive hydration and calming redness, though other products fit it better. It lacks sufficient rich, softening, and sealing ingredients to lock in moisture for optimal hydration. A product for this skin needs intensely hydrating and soothing ingredients that provide excellent comfort without any risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37377400/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this toner a good fit for dry skin?

Exosome cica and niacinamide make this toner a moderate fit for your dry skin by providing supportive hydration and barrier repair to calm redness and reduce flakiness. However, this skin type needs extra rich, softening ingredients that lock in moisture and prevent dryness for an ideal fit.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37377400/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What do Exosomes do for dry skin?

Exosomes help keep dry skin hydrated and strengthen the outer barrier so it holds onto moisture better. They may also improve elasticity, reduce rough patches, and help calm irritated skin by supporting natural healing and ceramide production.
Sources: [Dermatology Practical & Conceptual, 2026](https://pubmed.ncbi.nlm.nih.gov/41912205/), [Journal of Drugs in Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41931695/)

### What does Tea Tree Oil do for dry skin?

Tea tree oil is generally not a good fit for dry skin, as it tends to decrease oil levels and may cause irritation unless properly formulated. A product for dry skin needs nourishing, soothing ingredients that boost moisture and support the skin barrier without stripping away natural oils.
Sources: [International Journal of Cosmetic Science, 2022](https://pubmed.ncbi.nlm.nih.gov/34986500/)

### Where does this toner go in a skincare routine for dry skin?

This toner goes in your morning routine after cleansing and before your moisturizer and SPF, as part of a daily skincare regimen that helps improve skin hydration. A product for dry skin of this type needs rich softening and sealing ingredients to lock in moisture and prevent flakiness.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this toner with retinol, and in what order?

You can use this toner with retinol by applying it right after cleansing to calm your skin before your retinol product. Dry skin needs a rich moisturizer or face oil applied afterward to lock in moisture and prevent flaking.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22648223/)

### How often should I use this toner?

You can use this soothing toner once a week to start, and if your dry skin tolerates it well without irritation, you may carefully use it more often. Because dry skin needs extra moisture to stay soft and smooth, a product of this type needs rich ingredients and heavy oils to lock in hydration and prevent flakiness.

### Can this toner clog pores, cause breakouts or purging for dry skin?

This soothing toner is unlikely to clog pores or cause breakouts for dry skin, as it lacks heavy ingredients that tend to trap oil. While it provides supportive hydration, a product of this type needs richer, softening ingredients and sealing agents to deliver the optimal moisture that dry skin requires.

## Alternatives for dry skin

- [COSRX Cica Toner](https://lovi.care/skincare/ca/p/cosrx/cica-toner/for/dry-skin) — High fit — CA$24.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — CA$20.19 at Amazon
- Moisturizer: [Tata Harper Repairative Moisturizer](https://lovi.care/skincare/ca/p/tata-harper/repairative-moisturizer/for/dry-skin) — Superior fit — CA$162.00 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/ca/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — CA$38.00 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Exosome Cica, Tree, Niacinamide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-pad/for/dry-skin
- France: https://lovi.care/skincare/fr/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/dry-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/exosome-cica-calming-pad/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/exosome-cica-calming-pad/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/exosome-cica-calming-pad/for/dry-skin