# Medi-Peel Peptide 9 Volume Tox Cream for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medi-Peel](https://lovi.care/skincare/ca/brands/medi-peel)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by glycerin and sodium hyaluronate for humectant action, alongside hydrolyzed elastin and desamido collagen for collagen stimulation.
- The formula offers excellent moisturizing and anti-aging treatment due to sodium hyaluronate and palmitoyl pentapeptide-4, which hydrate the skin and minimize the appearance of fine lines and wrinkles.
- There are no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients, and the presence of soothing ingredients like Magnolia Officinalis Bark Extract and Tocopherol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptide 9, Sodium Hyaluronate, Copper Tripeptide-1, Hydrolyzed Collagen, Adenosine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Based on limited data, users highly praise this cream for its ability to deeply hydrate and plump the skin, resulting in a softer, bouncier, and glowing complexion, making it a favorite for aging and dry skin types. Its lightweight texture absorbs quickly without residue. While many appreciate its anti-aging benefits and pleasant scent, some users with acne-prone skin report breakouts, and a few find the moisture insufficient for very dry winter conditions.

- Liked: Hydrates and plumps (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Anti-aging effects (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Expensive for amount (rarely noted)
- Disliked: Not enough moisture (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Medi-Peel Peptide 9 Volume Tox Cream one of the best fits for mature skin?

This cream is one of the best fits for mature skin because it uses sodium hyaluronate and glycerin to deeply hydrate the skin, while peptides and collagen help reduce the look of fine lines and smooth the surface. It is very gentle on the skin and unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because it contains sodium hyaluronate and glycerin for deep hydration, alongside peptides like palmitoyl pentapeptide-4 to help minimize the appearance of fine lines and wrinkles. It also includes hydrolyzed collagen and elastin to support a firmer, smoother look.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Peptide 9 do for mature skin?

Peptide 9 helps smooth out fine lines and keeps mature skin feeling soft by encouraging the skin to build more collagen. This type of ingredient may improve firmness and overall elasticity, though results depend on consistent use.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19570099/), [Current Protein & Peptide Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34382523/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes near the end of your morning and evening skincare routines, right before sunscreen in the morning. It helps lock in hydration and pairs well with your other daily products.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, and applying it as a moisturizing step helps soothe the skin and supports comfort during treatment. Using a barrier-enhancing moisturizer alongside retinoids is known to improve skin tolerance and make the routine easier to stick with.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your routine. Applying it regularly helps keep mature skin well hydrated and minimizes the appearance of fine lines and wrinkles over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause purging, though some reviewers mention breakouts. Its gentle formula avoids harsh ingredients to keep your skin calm.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes or on the body, as its gentle formula is well-suited for delicate areas. The blend of glycerin, sodium hyaluronate, and peptides helps hydrate the skin and soften fine lines safely.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon
- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — CA$30.98 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/ca/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — CA$199.19 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Methylpropanediol, Glycerin, Dimethicone, Cyclopentasiloxane, 1,2-Hexanediol, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Olivate, Cyclohexasiloxane, Sorbitan Olivate, Glyceryl Stearate, Pentaerythrityl Tetraisostearate, Peg-100 Stearate, Cetearyl Glucoside, Carbomer, Arginine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Trehalose, Helianthus Annuus Seed Oil Sunflower Seed Oil, Xanthan Gum, Adenosine, Polysorbate 80, Sodium Hyaluronate, Disodium Edta, Sorbitan Oleate, Glycine Soja Oil Soybean Oil, Desamido Collagen, Juniperus Communis Fruit Extract, Magnolia Officinalis Bark Extract, Eucalyptus Globulus Leaf Extract, Fructan, Hydrolyzed Collagen, Butylene Glycol, Hydrogenated Polyisobutene, Bixa Orellana Seed Oil, Propanediol, Sodium Hyaluronate Crosspolymer, Sorbitan Laurate, Propylene Glycol, Hydrolyzed Glycosaminoglycans, Nonoxynol-12, Phenoxyethanol, Chondrus Crispus Extract, Tocopherol, Hydroxyethylcellulose, Benzyl Glycol, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Ethyl Hexanediol, Hydrolyzed Elastin, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hexapeptide-9, Palmitoyl Tetrapeptide-7, Acetyl Octapeptide-3, Raspberry Ketone, Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin