# Medi-Peel Peptide 9 Volume Tox Cream for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Medi-Peel](https://lovi.care/skincare/ca/brands/medi-peel)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration and anti-aging benefits for your combination skin, as sodium hyaluronate and palmitoyl pentapeptide-4 work to hydrate and minimize fine lines. Glycerin and trehalose further support hydration, but the formula lacks strong seboregulating ingredients to balance oilier areas.
- The product is safe for your acne-prone skin, with no harsh ingredients that would cause irritation.
- While it provides general hydration and soothing effects, it does not contain targeted ingredients to directly address your primary concerns of acne, blemishes, and breakouts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptide 9, Sodium Hyaluronate, Copper Tripeptide-1, Hydrolyzed Collagen, Adenosine

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Based on limited data, users highly praise this cream for its ability to deeply hydrate and plump the skin, resulting in a softer, bouncier, and glowing complexion, making it a favorite for aging and dry skin types. Its lightweight texture absorbs quickly without residue. While many appreciate its anti-aging benefits and pleasant scent, some users with acne-prone skin report breakouts, and a few find the moisture insufficient for very dry winter conditions.

- Liked: Hydrates and plumps (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Anti-aging effects (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Expensive for amount (rarely noted)
- Disliked: Not enough moisture (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Medi-Peel Peptide 9 Volume Tox Cream work for acne-prone skin?

This cream works moderately well for acne-prone skin, providing safe hydration without irritation, though it lacks targeted ingredients to directly manage breakouts. A moisturizing treatment for this skin type needs targeted ingredients to clear blemishes and regulate oil, alongside soothing agents and reliable hydrators.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for acne-prone skin?

This cream works safely on acne-prone skin, but it lacks targeted ingredients to directly address blemishes. A moisturizing treatment for this skin needs soothing extracts, oil-balancing agents, and ingredients that actively clear and prevent breakouts.

### What does Peptide 9 do for acne-prone skin?

Peptide 9 helps calm acne-prone skin and reduces breakouts by soothing inflammation in oil glands. It is unlikely to irritate dry areas while working to keep your skin clear and smooth.
Sources: [Journal of Immunology (Baltimore, Md, 2010](https://pubmed.ncbi.nlm.nih.gov/20610647/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this cream go in a skincare routine for acne-prone skin?

This moisturizing treatment goes near the end of your morning and evening routines, right before sunscreen in the morning. While it is safe for your skin, acne-prone skin needs products with oil-balancing ingredients like niacinamide to help manage breakouts.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream in your routine alongside retinol, applying it after your retinol treatment to help keep your skin comfortable and hydrated. This type of product works best for acne-prone skin when it includes oil-balancing ingredients and targeted blemish fighters to help keep breakouts clear.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily to keep your skin hydrated and soft. Regular application helps maintain moisture and supports your skin barrier without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to cause irritation, but it may cause breakouts for acne-prone skin because some reviewers note it triggers them. An acne-prone moisturizer needs oil-balancing ingredients and targeted blemish-fighting components to properly care for this skin type.

### Can I use this cream around the eyes or on my body?

This cream is generally safe to use on the delicate skin around the eyes or on the body, providing light hydration and soothing effects without causing irritation. However, because it lacks targeted ingredients for specific concerns like blemishes, a body or eye product of this type needs balancing ingredients like salicylic acid or niacinamide to properly manage breakouts and oil.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — CA$24.99 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — CA$95.99 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/ca/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — CA$49.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/ca/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — CA$24.50 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Methylpropanediol, Glycerin, Dimethicone, Cyclopentasiloxane, 1,2-Hexanediol, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Olivate, Cyclohexasiloxane, Sorbitan Olivate, Glyceryl Stearate, Pentaerythrityl Tetraisostearate, Peg-100 Stearate, Cetearyl Glucoside, Carbomer, Arginine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Trehalose, Helianthus Annuus Seed Oil Sunflower Seed Oil, Xanthan Gum, Adenosine, Polysorbate 80, Sodium Hyaluronate, Disodium Edta, Sorbitan Oleate, Glycine Soja Oil Soybean Oil, Desamido Collagen, Juniperus Communis Fruit Extract, Magnolia Officinalis Bark Extract, Eucalyptus Globulus Leaf Extract, Fructan, Hydrolyzed Collagen, Butylene Glycol, Hydrogenated Polyisobutene, Bixa Orellana Seed Oil, Propanediol, Sodium Hyaluronate Crosspolymer, Sorbitan Laurate, Propylene Glycol, Hydrolyzed Glycosaminoglycans, Nonoxynol-12, Phenoxyethanol, Chondrus Crispus Extract, Tocopherol, Hydroxyethylcellulose, Benzyl Glycol, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Ethyl Hexanediol, Hydrolyzed Elastin, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hexapeptide-9, Palmitoyl Tetrapeptide-7, Acetyl Octapeptide-3, Raspberry Ketone, Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin