# Mary Kay Timewise Night Solution for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Mary Kay](https://lovi.care/skincare/ca/brands/mary-kay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and anti-aging benefits for your combination skin, as Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 help improve elasticity and reduce fine lines, though these do not directly address your oily shine.
- The formulation is generally safe and suitable for combination skin, with Anthemis Nobilis Flower Extract providing soothing properties.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/oily-acne-prone-skin): Average

## Key ingredients

Palmitoyl Tripeptide-1, Retinyl Palmitate, Tocopheryl Acetate, Glycerin, Crithmum Maritimum Extract

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Preconditioning with samphire cell biomass formulations significantly accelerated epidermal permeability barrier repair kinetics after controlled stripping in healthy subjects older than 50 years compared to placebo and untreated sites. ([Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151937/))
- Extracellular vesicles derived from Crithmum maritimum callus and miR167 promote wound healing and skin regeneration in human fibroblasts by downregulating MMP1 and upregulating COL1A1 and VEGFA without cytotoxicity. ([Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40867601/))
- The full-component extract of Crithmum maritimum significantly promotes epidermal regeneration of UV-induced skin damage in a barrier-weakening 3D full-skin model compared to oil-based extract components. ([RSC Advances, 2025](https://pubmed.ncbi.nlm.nih.gov/39835209/))

## Why other moisturizers fit combination skin better

- A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28342238/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Timewise Night Solution work for combination skin?

Mary Kay Timewise Night Solution works moderately well for combination skin, offering basic moisture and anti-aging benefits with peptides that help smooth fine lines, though it does not directly manage oily shine. A treatment of this type needs effective hydrating ingredients that balance moisture levels without causing excess oiliness, alongside soothing agents for dry and oily areas.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Which ingredients make this serum a good fit for combination skin?

Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 help improve elasticity and reduce fine lines on combination skin, while Anthemis Nobilis Flower Extract provides soothing properties. Because this treatment only offers moderate benefits and does not directly address oily shine, a product for this skin needs ingredients that balance moisture levels without causing excess oiliness, hydrate both dry and oily areas effectively, and help control shine.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### What does Palmitoyl Tripeptide-1 do for combination skin?

Palmitoyl tripeptide-1 helps smooth fine lines and supports firmness in combination skin when used as part of an anti-aging routine. Studies show that ingredients like this peptide can improve overall skin texture and boost collagen levels when applied consistently over time.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### What does Retinyl Palmitate do for combination skin?

Retinyl palmitate helps smooth fine lines, even out skin tone, and improve texture on combination skin. Because it works gently, it is unlikely to cause irritation while helping keep both dry and oily areas looking clear and firm.
Sources: [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though it can also be used in the morning or twice a day. This product works for your combination skin by offering moderate moisture and firmness, but combination skin also needs lightweight, oil-balancing ingredients that manage oily shine.

### Can I use this serum with niacinamide, and in what order?

You can use this treatment alongside niacinamide by applying niacinamide first and following with this treatment once it absorbs. To better fit combination skin, this product needs ingredients that balance oily shine while providing moisture.

### How often should I use this serum?

This treatment is used in the evening as part of your nightly routine, starting with once a day for simplicity and extra safety around sun exposure. To better fit combination skin, this type of product also needs ingredients that help balance oily shine.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts on combination skin, and it does not contain ingredients that typically cause purging. It helps keep skin smooth while soothing it, though combination skin also needs lightweight, oil-controlling ingredients to properly manage oily shine.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Can I use this serum around the eyes or on my body?

This product works fine on the face, but because the skin around the eyes is much thinner and the skin on the body is thicker, treatment needs ingredients tailored to those specific thicknesses for the best results.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/ca/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/combination-skin) — High fit — CA$40.50 at Amazon
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ca/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/combination-skin) — High fit — CA$25.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/combination-skin) — High fit — CA$21.81 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Glycerin, 1-Methylhydantoin-2-Imide, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tocopheryl Acetate, Retinyl Palmitate, Ascorbyl Palmitate, Crithmum Maritimum Extract, Geranium Extract, Mentha Arvensis Leaf Extract, Anthemis Nobilis Flower Extract, Rosa Centifolia Flower Extract, Citrus Aurantium Dulcis Flower Extract, Jasmine Extract, Ferula Galbaniflua Extract Gum, Cananga Odorata Flower Extract, Ribes Nigrum Fruit Extract Black Current Fruit Extract, Propylene Glycol, Hydroxyethylcellulose, Mannitol, Acrylates Vinyl Isodecanoate Crosspolymer, Cellulose, Hydroxypropyl Methylcellulose, Triethyl Citrate, Acrylates Ammonium Methacrylate Copolymer, Polysorbate 20, Carbomer, Triethanolamine, Disodium Edta, Talc, Methylparaben, Dmdm Hydantoin, Mica, Titanium Dioxide, Ultramarines, Red 30
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mary-kay/timewise-night-solution/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mary-kay/timewise-night-solution/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/mary-kay/timewise-night-solution/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/mary-kay/timewise-night-solution/for/combination-skin
- France: https://lovi.care/skincare/fr/p/mary-kay/timewise-night-solution/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/mary-kay/timewise-night-solution/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/mary-kay/timewise-night-solution/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/mary-kay/timewise-night-solution/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/mary-kay/timewise-night-solution/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/mary-kay/timewise-night-solution/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mary-kay/timewise-night-solution/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/combination-skin