# MARY & MAY 6 Peptide Complex Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [MARY & MAY](https://lovi.care/skincare/ca/brands/mary-and-may)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your acne and oiliness as peptides like copper tripeptide-1 and hexapeptide-11 can support skin repair and potentially regulate sebum, which is suitable for your oily skin without contributing to excess oiliness.
- The serum provides excellent plumping and firming effects due to multiple peptides such as palmitoyl pentapeptide-4, enhancing overall skin health.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1

## What the research says

- Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects. ([Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/))
- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Combined therapy using a topical hyaluronic acid-niacinamide-Matrixyl serum and a multimodal facial device decreased TruSkin age by five years and reduced wrinkles more effectively than the serum alone in a 41-year-old woman with moderate facial aging over 12 weeks. ([Cureus, 2026](https://pubmed.ncbi.nlm.nih.gov/42500768/))
- A functionalized dendrimer nanocarrier delivers active ingredients into the dermis and enhances collagen production in human dermal fibroblasts by co-delivering all-trans retinol and palmitoyl pentapeptide-4. ([Acta Biomaterialia, 2025](https://pubmed.ncbi.nlm.nih.gov/39694719/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence. ([Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23578831/))
- Topical treatment with cyclized hexapeptide-9 significantly reduced wrinkles and roughness in crow's feet and forehead compared to vehicle, and generally outperformed retinol in healthy volunteers with aging skin. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/))
- A chemically synthesized homotrimeric collagen peptide exhibited high purity, a stable triple-helical conformation, and excellent thermal stability, while safely enhancing collagen and elastin synthesis in fibroblasts in vitro and increasing skin collagen content, improving skin structure, and enhancing microvessel density in BALB/c mice in vivo. ([Frontiers in Bioengineering and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40357327/))
- The addition of soybean peptide and collagen peptide to normal human dermal fibroblasts increased collagen synthesis and gene expression related to collagen formation, with the highest collagen levels observed when both peptides were added together compared to individual additions. ([International Journal of Food Sciences and Nutrition, 2012](https://pubmed.ncbi.nlm.nih.gov/22264122/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Based on a very large amount of data, users with diverse skin types consistently praise this serum for its lightweight hydration and ability to plump the skin without irritation. While it is not a miracle cure for deep wrinkles, the majority of users report smoother skin texture, improved elasticity, and a reduction in fine lines after consistent use.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Gentle & non-irritating (often mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Good value (sometimes noted)
- Disliked: Subtle or slow results (sometimes noted)
- Disliked: Consumed quickly (rarely noted)
- Disliked: Rare skin reactions (rarely noted)
- Disliked: Texture too watery (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Mary & May 6 Peptide Complex Serum work for oily acne-prone skin?

Mary & May 6 Peptide Complex Serum is a moderate fit for your oily acne-prone skin, as its peptides help support skin repair and firming without causing extra oiliness or irritation. To work best for this skin type, a treatment of this kind needs targeted ingredients like niacinamide, propolis, or Vitamin C to actively control oil and clear breakouts.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Copper Tripeptide-1 and Hexapeptide-11 make this serum a good fit by supporting skin repair and helping regulate sebum for oily skin. To work best for oily and acne-prone skin, a treatment of this type needs soothing extracts, oil-controlling ingredients like niacinamide or Vitamin C, and lightweight hydrators.

### What does Copper Tripeptide-1 do for oily acne-prone skin?

Copper Tripeptide-1 helps calm oily, acne-prone skin by reducing inflammation and protecting against damage, while also improving overall skin barrier health. This ingredient supports tissue repair and helps smooth out skin texture, making it a useful addition for managing breakouts.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [Journal of Biomaterials Science. Polymer Edition, 2008](https://pubmed.ncbi.nlm.nih.gov/18644225/)

### What does Hexapeptide-11 do for oily acne-prone skin?

Hexapeptide-11 helps protect skin cells from everyday damage and may improve firmness, but oily acne-prone skin also needs ingredients that control oil and soothe swelling to truly stay clear and smooth.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine after cleansing and toning, and before moisturizing. Oily acne-prone skin needs a treatment of this type to include ingredients that help repair skin and regulate oil without clogging pores.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, applying the treatment serum after cleansing and toning, and before your moisturizer. It is unlikely to cause irritation due to its gentle formula, but oily acne-prone skin often needs targeted ingredients like salicylic acid or niacinamide to better manage breakouts and excess oil.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. This serum is unlikely to cause irritation for your oily skin, though an oily acne-prone skin type needs a product that also features ingredients to actively clear pores and control breakouts.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on oily acne-prone skin because it has a very safe formula with no harsh or heavy ingredients. However, it only works moderately well for oiliness and acne, so oily acne-prone skin needs a product of this type that also includes lightweight, oil-balancing ingredients and acne-fighting components.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$28.99 (https://www.amazon.ca/dp/B095YHYF33?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 1 Nov 2026.

## Ingredients

Water, Glycereth-26, 1,2-Hexanediol, Butylene Glycol, Glycerin, Arginine, Carbomer, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Adenosine, Caprylyl Glycol, Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Tripeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin