# MARY & MAY 6 Peptide Complex Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [MARY & MAY](https://lovi.care/skincare/ca/brands/mary-and-may)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your dry skin, as glycerin and butylene glycol provide hydration, while multiple peptides like copper tripeptide-1 and palmitoyl pentapeptide-4 support skin barrier repair and collagen synthesis.
- The serum is safe for your dry skin, with no harsh ingredients that could cause irritation.
- While it offers general skincare benefits, the formulation does not specifically target dryness or flakiness beyond basic hydration.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases. ([Inflammation Research, 2010](https://pubmed.ncbi.nlm.nih.gov/20703511/))
- Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects. ([Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/))
- Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence. ([Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23578831/))
- Topical treatment with cyclized hexapeptide-9 significantly reduced wrinkles and roughness in crow's feet and forehead compared to vehicle, and generally outperformed retinol in healthy volunteers with aging skin. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/))
- A chemically synthesized homotrimeric collagen peptide exhibited high purity, a stable triple-helical conformation, and excellent thermal stability, while safely enhancing collagen and elastin synthesis in fibroblasts in vitro and increasing skin collagen content, improving skin structure, and enhancing microvessel density in BALB/c mice in vivo. ([Frontiers in Bioengineering and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40357327/))
- The addition of soybean peptide and collagen peptide to normal human dermal fibroblasts increased collagen synthesis and gene expression related to collagen formation, with the highest collagen levels observed when both peptides were added together compared to individual additions. ([International Journal of Food Sciences and Nutrition, 2012](https://pubmed.ncbi.nlm.nih.gov/22264122/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## Why other serums fit dry skin better

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))

## What reviewers say

Based on a very large amount of data, users with diverse skin types consistently praise this serum for its lightweight hydration and ability to plump the skin without irritation. While it is not a miracle cure for deep wrinkles, the majority of users report smoother skin texture, improved elasticity, and a reduction in fine lines after consistent use.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Gentle & non-irritating (often mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Good value (sometimes noted)
- Disliked: Subtle or slow results (sometimes noted)
- Disliked: Consumed quickly (rarely noted)
- Disliked: Rare skin reactions (rarely noted)
- Disliked: Texture too watery (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Mary & May 6 Peptide Complex Serum work for dry skin?

Mary & May 6 Peptide Complex Serum works moderately well for dry skin, offering basic hydration and support for your skin barrier through ingredients like glycerin and various peptides, though it lacks targeted ingredients for severe dryness or flakiness. A treatment for dry skin needs rich, highly effective soothing ingredients like ceramides, propolis, or niacinamide to deliver significant hydration, nourishment, and a healthy glow without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin and butylene glycol help by providing basic hydration, while peptides like copper tripeptide-1 and palmitoyl pentapeptide-4 support skin barrier repair. To work best for dry skin, a product of this type needs rich ingredients that specifically target dryness and flakiness with soothing hydration, ceramides, and vitamins.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### What does Copper Tripeptide-1 do for dry skin?

Copper Tripeptide-1 helps soothe dry skin and improves your skin barrier and wrinkles. This ingredient supports skin regeneration and helps protect your skin from damage.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [BioMed Research International, 2015](https://pubmed.ncbi.nlm.nih.gov/26236730/)

### What does Hexapeptide-11 do for dry skin?

Hexapeptide-11 is unlikely to provide direct moisture for dry skin, as its primary benefits focus on protecting cells and improving skin elasticity rather than relieving dryness. To properly care for dry skin, this type of product needs hydrating ingredients like hyaluronic acid or glycerin along with nourishing plant oils.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in your evening routine after cleansing and before moisturizing. To better fit dry skin, a product of this type needs richer hydrators and ingredients that target dryness and flakiness.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your dry skin a boost of hydration, followed by your retinol. The serum is unlikely to cause irritation, but a product for dry skin also needs richer moisturizers or oils to lock in hydration and smooth flakiness.

### How often should I use this serum?

You can use this treatment in your evening routine. A dry skin type of average fit needs a product that also brings richer moisturizing ingredients and oils to tackle dryness and flakiness effectively.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts or clog pores on dry skin, as it has a lightweight, water-like feel and lacks heavy oils. It features glycerin and multiple peptides that help keep skin hydrated without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ca/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — CA$40.00 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — CA$22.49 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — CA$20.19 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/ca/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — CA$27.99 at Amazon
- Moisturizer: [Tata Harper Repairative Moisturizer](https://lovi.care/skincare/ca/p/tata-harper/repairative-moisturizer/for/dry-skin) — Superior fit — CA$162.00 at Amazon

## Where to buy

- Amazon.ca: CA$28.99 (https://www.amazon.ca/dp/B095YHYF33?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 1 Nov 2026.

## Ingredients

Water, Glycereth-26, 1,2-Hexanediol, Butylene Glycol, Glycerin, Arginine, Carbomer, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Adenosine, Caprylyl Glycol, Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Tripeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/dry-skin (this page)
- Australia: https://lovi.care/skincare/au/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mary-and-may/6-peptide-complex-serum/for/dry-skin