make p:rem UV Defense Me Daily Sun Fluid SPF 50+ PA++++ for skin with dark spots

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Liposomal encapsulation of octyl methoxycinnamate increases its safety, skin affinity, and in vivo solar photoprotection factor while slowing its release and enhancing retention in the stratum corneum compared to a conventional formulation.

  International Journal of Nanomedicine, 2013

• Emulgels containing Perilla frutescens seed oil, Moringa oleifera seed oil, and mixed seed oil microemulsions exhibit good stability, lack of cytotoxicity in PBMC, and no skin irritation or allergic reactions in human subjects.

  Polymers, 2022

• Moringa seed oil stimulated sebaceous lipogenesis, reduced pro-inflammatory cytokine secretion, and exhibited a low n-6/n-3 index in cultured human SZ95 sebocytes compared to untreated cells.

  International Journal of Molecular Sciences, 2023

• Topical Moringa oleifera seed oil and its main constituent oleic acid reduced acute and chronic skin inflammation and epidermal hypertrophy in mice through glucocorticoid receptor activation without dexamethasone-like adverse effects on organ weights.

  Journal of Ethnopharmacology, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Ingredients

Water, Cyclopentasiloxane, Zinc Oxide, Ethylhexyl Methoxycinnamate, Butylene Glycol, Titanium Dioxide, Glycerin, Niacinamide, C12-15 Alkyl Benzoate, Caprylyl Methicone, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Dimethicone, Sodium Chloride, Aluminum Hydroxide, Stearic Acid, Triethoxycaprylylsilane, Acrylates Dimethicone Copolymer, Disteardimonium Hectorite, Phenoxyethanol, Ethylhexylglycerin, Adenosine, Tocopherol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.