ma:nyo Bifida Biome Aqua Barrier Cream for skin with dark spots

How to apply

Questions and answers

What the research says

• Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.

  Journal of Cosmetic Dermatology, 2023

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Ingredients

Bifida Lysate Ferment, Centella Asiatica Leaf Water, Water, Propanediol, Glycerin, Butylene Glycol, Niacinamide, Isononyl Isononanoate, 1,2-Hexanediol, Hydrogenated Polydecene, Pentylene Glycol, Dimethicone, Bifida Ferment Filtrate, Lactobacillus Pumpkin Fruit Ferment Filtrate, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Saccharomyces Ferment Filtrate, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Lactobacillus Ferment, Witch Hazel Water, Vincetoxicum Atratum Extract, Anastatica Hierochuntica Extract, Chrysanthemum Zawadskii Extract, Artemisia Capillaris Extract, Cyperus Rotundus Root Extract, Leonurus Sibiricus Stem Extract Flower Leaf, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Oenothera Biennis Extract, Pinus Palustris Leaf Extract, Pueraria Lobata Root Extract, Ulmus Davidiana Root Extract, Panthenol, Borago Officinalis Extract, Centaurea Cyanus Flower Extract, Chamomilla Recutita Leaf Extract Flower Matricaria Leaf Extract Flower, Hyacinthus Orientalis Extract, Lavender Flower Water, Salvia Sclarea Extract, Ceramide Np, Hydrogenated Olive Oil, Squalane, Sodium Hyaluronate Crosspolymer, Fructooligosaccharides, Fructose, Tromethamine, Asiaticoside, Asiatic Acid, Madecassic Acid, Chlorella Vulgaris Extract, Pentaerythrityl Tetraethylhexaate, Paeonia Albiflora Flower Extract, Gossypium Herbaceum Seed Extract, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polydecene, Glucose, Polyglyceryl-3 Methylglucose Distearate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Theobroma Cacao Seed Extract, Hydrolyzed Glycosaminoglycans, Agar, Guar Gum, Xanthan Gum, Ethylhexylglycerin, Glyceryl Acrylate Acrylic Acid Copolymer, Dimethyl Sulfone, Betaine Salicylate, Hydrogenated Lecithin, Benzyl Glycol, Dextrin, Sodium Phytate, Adenosine, Tocopherol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.