# Lancôme Advanced Génifique Youth Activating Concentrate for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Lancôme](https://lovi.care/skincare/ca/brands/lancome)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your oily skin with glycerin and sodium hyaluronate providing hydration and salicylic acid for mild exfoliation, though these are not specifically targeted for your acne, blemishes, and breakouts.
- Bifida ferment lysate and adenosine are present to enhance barrier resilience and minimize fine lines, offering general skincare advantages.
- The product is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Bifida Lysate Ferment, Sodium Hyaluronate, Ascorbyl Glucoside, Adenosine, Caprylyl Glycol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- A preservative system containing 1,2-hexanediol and caprylyl glycol showed no delayed Type IV dermal sensitivity reactions in 200 subjects when tested as a 15% mixture in carbomer gel and in a cosmetic formulation. ([Cutaneous and Ocular Toxicology, 2009](https://pubmed.ncbi.nlm.nih.gov/19514921/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users love this serum's lightweight, fast-absorbing texture that provides immediate hydration and a noticeable glow without stickiness. Many report smoother skin and reduced fine lines quickly. Some users, particularly those with sensitive skin, experienced breakouts, and a number found the high price point not justified by the anti-aging results.

- Liked: Improves skin texture (mostly mentioned)
- Liked: Boosts radiance (often mentioned)
- Liked: Fast absorption (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Smart packaging (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Alcohol content (rarely noted)
- Disliked: Caused breakouts (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Lancôme Advanced Génifique work for oily acne-prone skin?

This treatment works moderately well for oily acne-prone skin, providing basic hydration and barrier support while remaining safe from irritation. However, because it lacks targeted blemish-fighting ingredients, an oily acne-prone skin type needs a product formulated with niacinamide, propolis, or vitamin C to better control excess oil and clear breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Glycerin and sodium hyaluronate provide lightweight hydration, while mild exfoliating ingredients help keep oily skin smooth. To better fit oily, acne-prone skin, a treatment of this type needs ingredients like niacinamide, propolis, or Vitamin C to actively target breakouts and excess oil while supporting a healthy glow.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bifida Ferment Lysate do for oily acne-prone skin?

Bifida Ferment Lysate helps calm oily acne-prone skin by strengthening your skin barrier and lowering irritation. It is unlikely to clog pores and may help keep your skin feeling smooth and balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though some serums may also be used in the morning or twice a day. It is safe for oily skin and unlikely to cause irritation, but acne-prone skin needs products with targeted blemish-fighting ingredients and oil-balancing benefits.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first and following it with your retinol once it absorbs. This product is unlikely to cause irritation on oily skin, but oily acne-prone skin needs ingredients like salicylic acid or benzoyl peroxide to directly target breakouts and blemishes.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Oily acne-prone skin needs a product with targeted blemish-fighting ingredients and oil-controlling components rather than general hydrators and barrier boosters.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to cause irritation or breakouts on your oily skin, though a few reviewers have reported pimples. To properly care for oily, acne-prone skin, a product of this type needs targeted blemish-clearing ingredients like salicylic acid and oil-balancing agents.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (limonene and citronellol) and drying alcohol (alcohol denat).

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$270.00 (https://www.amazon.ca/dp/B081CJ98TR?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Bifida Lysate Ferment, Glycerin, Alcohol Denat, Dimethicone, Hydroxyethylpiperazine Ethane Sulfonic Acid, Ascorbyl Glucoside, Sodium Hyaluronate, Sodium Hydroxide, Sodium Benzoate, Phenoxyethanol, Adenosine, Faex Yeast Extrait De Levure Extract, Peg-20 Methyl Glucose Sesquistearate, Peg-60 Hydrogenated Castor Oil, Salicyloyl Phytosphingosine, Ammonium Polyacryldimethyltauramide Ammonium Polyacryloyldimethyl Taurate, Limonene, Xanthan Gum, Caprylyl Glycol, Disodium Edta, Octyldodecanol, Citronellol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin